Search Results - "Stachowiak, Jeanne"

Clathrin: Bender or bystander? by Stachowiak, Jeanne C

“…Cell biologists have long debated the role of clathrin in curving membranes during endocytosis. New findings from Cail et al. (2022. J. Cell…”
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The beauty of simplicity in membrane biology by Stachowiak, Jeanne C., Kirchhausen, Tomas

“…For the past 40 years, minimal reconstituted systems have helped cell biologists to understand the mechanisms that underlie membrane traffic. Having progressed…”
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Kinetic trapping organizes actin filaments within liquid-like protein droplets by Chandrasekaran, Aravind, Graham, Kristin, Stachowiak, Jeanne C., Rangamani, Padmini

“…Several actin-binding proteins (ABPs) phase separate to form condensates capable of curating the actin network shapes. Here, we use computational modeling to…”
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Membrane bending by protein phase separation by Yuan, Feng, Alimohamadi, Haleh, Bakka, Brandon, Trementozzi, Andrea N., Day, Kasey J., Fawzi, Nicolas L., Rangamani, Padmini, Stachowiak, Jeanne C.

“…Membrane bending is a ubiquitous cellular process that is required for membrane traffic, cell motility, organelle biogenesis, and cell division. Proteins that…”
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Modeling the mechanisms through which protein phase separation induces membrane curvature by Zinga, Ketsia, Stachowiak, Jeanne C., Ren, Pengyu

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A cost–benefit analysis of the physical mechanisms of membrane curvature by Stachowiak, Jeanne C., Brodsky, Frances M., Miller, Elizabeth A.

“…Multiple processes in the cell require curved membranes. Stachowiak, Brodsky and Miller discuss how lipids and vesicle cargo proteins represent energy barriers…”
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Transmembrane coupling of liquid-like protein condensates by Lee, Yohan, Park, Sujin, Yuan, Feng, Hayden, Carl C., Wang, Liping, Lafer, Eileen M., Choi, Siyoung Q., Stachowiak, Jeanne C.

“…Liquid-liquid phase separation of proteins occurs on both surfaces of cellular membranes during diverse physiological processes. In vitro reconstitution could…”
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Liquid-like protein interactions catalyse assembly of endocytic vesicles by Day, Kasey J., Kago, Grace, Wang, Liping, Richter, J. Blair, Hayden, Carl C., Lafer, Eileen M., Stachowiak, Jeanne C.

“…During clathrin-mediated endocytosis, dozens of proteins assemble into an interconnected network at the plasma membrane. As initiators of endocytosis, Eps15…”
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Liquid-like VASP condensates drive actin polymerization and dynamic bundling by Graham, Kristin, Chandrasekaran, Aravind, Wang, Liping, Ladak, Aly, Lafer, Eileen M., Rangamani, Padmini, Stachowiak, Jeanne C.

“…The organisation of actin filaments into bundles is required for cellular processes such as motility, morphogenesis and cell division. A network of…”
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Membrane fission by protein crowding by Snead, Wilton T., Hayden, Carl C., Gadok, Avinash K., Zhao, Chi, Lafer, Eileen M., Rangamani, Padmini, Stachowiak, Jeanne C.

“…Membrane fission, which facilitates compartmentalization of biological processes into discrete, membrane-bound volumes, is essential for cellular life…”
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Intrinsically disordered proteins drive membrane curvature by Busch, David J., Houser, Justin R., Hayden, Carl C., Sherman, Michael B., Lafer, Eileen M., Stachowiak, Jeanne C.

“…Assembly of highly curved membrane structures is essential to cellular physiology. The prevailing view has been that proteins with curvature-promoting…”
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Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing by Zeno, Wade F., Baul, Upayan, Snead, Wilton T., DeGroot, Andre C. M., Wang, Liping, Lafer, Eileen M., Thirumalai, D., Stachowiak, Jeanne C.

“…The ability of proteins to sense membrane curvature is essential to cellular function. All known sensing mechanisms rely on protein domains with specific…”
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Lateral compression of lipids drives transbilayer coupling of protein condensates by Lee, Yohan, Park, Sujin, Yuan, Feng, Stachowiak, Jeanne C.

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Lipid droplets as flexible substrates for protein phase separation by Kamatar, Advika, Stachowiak, Jeanne C., Parekh, Sapun H.

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Molecular Mechanisms of Membrane Curvature Sensing by a Disordered Protein by Zeno, Wade F, Thatte, Ajay S, Wang, Liping, Snead, Wilton T, Lafer, Eileen M, Stachowiak, Jeanne C

“…The ability of proteins to sense membrane curvature is essential for the initiation and assembly of curved membrane structures. Established mechanisms of…”
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BAR scaffolds drive membrane fission by crowding disordered domains by Snead, Wilton T, Zeno, Wade F, Kago, Grace, Perkins, Ryan W, Richter, J Blair, Zhao, Chi, Lafer, Eileen M, Stachowiak, Jeanne C

“…Cellular membranes are continuously remodeled. The crescent-shaped bin-amphiphysin-rvs (BAR) domains remodel membranes in multiple cellular pathways. Based on…”
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Light-Activated Assembly of Connexon Nanopores in Synthetic Cells by Sihorwala, Ahmed Z., Lin, Alexander J., Stachowiak, Jeanne C., Belardi, Brian

“…During developmental processes and wound healing, activation of living cells occurs with spatiotemporal precision and leads to rapid release of soluble…”
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Biophysical forces in membrane bending and traffic by Day, Kasey J., Stachowiak, Jeanne C.

“…Intracellular trafficking requires extensive changes in membrane morphology. Cells use several distinct molecular factors and physical cues to remodel…”
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Systems biology of cellular membranes: a convergence with biophysics by Chabanon, Morgan, Stachowiak, Jeanne C., Rangamani, Padmini

“…Systems biology and systems medicine have played an important role in the last two decades in shaping our understanding of biological processes. While systems…”
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A live cell imaging-based assay for tracking particle uptake by clathrin-mediated endocytosis by Ashby, Grant, Keng, Kayla E, Hayden, Carl C, Stachowiak, Jeanne C

“…A popular strategy for therapeutic delivery to cells and tissues is to encapsulate therapeutics inside particles that cells internalize via endocytosis. The…”
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