Search Results - "Stacey, Maria"

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence by Clement, Mathew, Marsden, Morgan, Stacey, Maria A, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana, Scurr, Martin J, Ghazal, Peter, Weaver, Casey T, Carlesso, Gianluca, Clare, Simon, Jones, Simon A, Godkin, Andrew, Jones, Gareth W, Humphreys, Ian R

“…CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts…”
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Neutrophils Recruited by IL-22 in Peripheral Tissues Function as TRAIL-Dependent Antiviral Effectors against MCMV by Stacey, Maria A., Marsden, Morgan, Pham N, Tu Anh, Clare, Simon, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Klenerman, Paul, Gallimore, Awen M., Taylor, Philip R., Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A., Wilkinson, Gavin W.G., Humphreys, Ian R.

“…During primary infection, murine cytomegalovirus (MCMV) spreads systemically, resulting in virus replication and pathology in multiple organs. This…”
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IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine by McLaren, James E, Clement, Mathew, Marsden, Morgan, Miners, Kelly L, Llewellyn-Lacey, Sian, Grant, Emma J, Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A, Orr, Selinda J, Stanton, Richard J, Ladell, Kristin, Price, David A, Humphreys, Ian R

“…Candidate vaccines designed to generate T cell-based immunity are typically vectored by nonpersistent viruses, which largely fail to elicit durable effector…”
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The Role of IL-22 in Viral Infections: Paradigms and Paradoxes by Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A, Redwood, Alec J, Humphreys, Ian R

“…Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric…”
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The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis by Stacey, Maria A, Clare, Simon, Clement, Mathew, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A, Smith, Sarah E, Wash, Rachael S, Brias, Silvia Gimeno, Stack, Gabrielle, Notley, George, Cambridge, Emma L, Isherwood, Christopher, Speak, Anneliese O, Johnson, Zoë, Ferlin, Walter, Jones, Simon A, Kellam, Paul, Humphreys, Ian R

“…The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3…”
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CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue by Stack, Gabrielle, Jones, Emma, Marsden, Morgan, Stacey, Maria A, Snelgrove, Robert J, Lacaze, Paul, Jacques, Laura C, Cuff, Simone M, Stanton, Richard J, Gallimore, Awen M, Hussell, Tracy, Wilkinson, Gavin W G, Ghazal, Peter, Taylor, Philip R, Humphreys, Ian R

“…CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200…”
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Estimating the Number of Sex Workers in South Africa: Rapid Population Size Estimation by Konstant, Tracey L., Rangasami, Jerushah, Stacey, Maria J., Stewart, Michelle L., Nogoduka, Coceka

“…Although recognized as a vulnerable population, there is no national population size estimate for sex workers in South Africa. A rapid sex worker enumeration…”
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IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection by Stacey, Maria A, Marsden, Morgan, Wang, Eddie C Y, Wilkinson, Gavin W G, Humphreys, Ian R

“…IL-10 is an immunomodulatory cytokine that acts to antagonize T cell responses elicited during acute and chronic infections. Thus, the IL-10R signaling pathway…”
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IL-10 restricts memory T cell inflation during cytomegalovirus infection by Jones, Morgan, Ladell, Kristin, Wynn, Katherine K, Stacey, Maria A, Quigley, Máire F, Gostick, Emma, Price, David A, Humphreys, Ian R

“…The beta-herpesvirus CMV induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral…”
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Herpesvirus exploitation of host immune inhibitory pathways by Stack, Gabrielle, Stacey, Maria A, Humphreys, Ian R

“…Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of…”
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LESSONS FROM THE EVALUATION OF A PUBLIC OUT-PATIENT SUBSTANCE ABUSE TREATMENT PROGRAMME IN THE WESTERN CAPE by Strebel, Anna, Shefer, Tamara, Stacey, Maria, Shabalala, Nokuthula

“…Given the extent of alcohol and substance abuse in South Africa, there is an urgent need for effective, evidence-based interventions. This study reports on…”
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Heightened risk of unintended pregnancy among sex workers and sex worker organizations’ response during the stringent COVID-19 containment measures in East and Southern Africa by Modisaotsile, Innocent, Stacey, Maria, Odek, Willis, Ogutu, Daughtie, Kindyomunda, Rosemary

“…The UNFPA 2022 State of the World Population (SWOP) report recognises that certain populations of young women and girls are at a higher risk of unintended…”
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ID: 200 by Clement, Mathew, Stacey, Maria A., Marsden, Morgan, Jones, Gareth, Jones, Simon A., Humphreys, Ian R.

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ID: 200: IL-27 enhances MCMV chronicity by promoting the development of immune suppressive virus-specific IL-10+ CD4+ T-cells by Clement, Mathew, Stacey, Maria A., Marsden, Morgan, Jones, Gareth, Jones, Simon A., Humphreys, Ian R.

“…Human cytomegalovirus (HCMV) is an important viral pathogen in the immune suppressed and immunologically immature. HCMV encodes a functional homologue of the…”
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Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG by Rigaud, Stéphanie, Lopez-Granados, Eduardo, Sibéril, Sophie, Gloire, Geoffrey, Lambert, Nathalie, Lenoir, Christelle, Synaeve, Cindy, Stacey, Maria, Fugger, Lars, Stephan, Jean-Louis, Fischer, Alain, Picard, Capucine, Durandy, Anne, Chapel, Helen, Latour, Sylvain

“…The present study focuses on a large family with an X-linked immunodeficiency in which there are variable clinical and laboratory phenotypes, including…”
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Cytomegalovirus-Specific IL-10-Producing CD4.sup.+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence by Clement, Mathew, Marsden, Morgan, Stacey, Maria A, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana, Scurr, Martin J, Ghazal, Peter, Weaver, Casey T, Carlesso, Gianluca, Clare, Simon, Jones, Simon A, Godkin, Andrew, Jones, Gareth W, Humphreys, Ian R

“…CD4.sup.+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4.sup.+ T cells from systemic and mucosal tissues…”
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ID: 170: IFITM3 restricts virus-induced pathogenesis by regulating myeloid cell production of interleukin-6 by Stacey, Maria A., Clare, Simon, Marsden, Morgan, Clement, Mathew, Fielding, Ceri A., Johnson, Zoë, Ferlin, Walter, Jones, Simon A., Kellam, Paul, Humphreys, Ian R.

“…The antiviral restriction factor interferon-induced transmembrane protein 3 (IFITM3) inhibits endocytosis-dependent entry of numerous viruses and determines…”
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ID: 170 by Stacey, Maria A., Clare, Simon, Marsden, Morgan, Clement, Mathew, Fielding, Ceri A., Johnson, Zoë, Ferlin, Walter, Jones, Simon A., Kellam, Paul, Humphreys, Ian R.

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IL-22 driven neutrophils afford critical protection from acute murine cytomegalovirus infection (P6310) by Stacey, Maria, Marsden, Morgan, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Taylor, Philip, Jones, Simon, Snelgrove, Robert, Wilkinson, Gavin, Humphreys, Ian

“…Abstract Pathogenic herpesviruses including cytomegalovirus target numerous host organs during infection, but the immunological mechanisms that afford…”
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Interleukin-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection by Stacey, Maria A., Marsden, Morgan, Wang, Eddie C.Y., Wilkinson, Gavin W.G., Humphreys, Ian R.

“…Interleukin-10 (IL-10) is an immunomodulatory cytokine that acts to antagonize T cell responses elicited during acute and chronic infections. The IL-10…”
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