Search Results - "Stacey, Kevin"

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency by Tordo, Julie, O'Leary, Claire, Antunes, André S L M, Palomar, Nuria, Aldrin-Kirk, Patrick, Basche, Mark, Bennett, Antonette, D'Souza, Zelpha, Gleitz, Hélène, Godwin, Annie, Holley, Rebecca J, Parker, Helen, Liao, Ai Yin, Rouse, Paul, Youshani, Amir Saam, Dridi, Larbi, Martins, Carla, Levade, Thierry, Stacey, Kevin B, Davis, Daniel M, Dyer, Adam, Clément, Nathalie, Björklund, Tomas, Ali, Robin R, Agbandje-McKenna, Mavis, Rahim, Ahad A, Pshezhetsky, Alexey, Waddington, Simon N, Linden, R Michael, Bigger, Brian W, Henckaerts, Els

“…Tordo et al. present a novel AAV gene therapy vector, AAV-TT, which exceeds the current benchmark neurotropic serotypes AAV9 and AAVrh10 and enables…”
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Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity by Stacey, Kevin B, Breen, Eamon, Jefferies, Caroline A

“…Patients suffering from Systemic Lupus Erythematous (SLE) have elevated type I interferon (IFN) levels which correlate with disease activity and severity…”
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Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing by Smith, Samantha L., Kennedy, Philippa R., Stacey, Kevin B., Worboys, Jonathan D., Yarwood, Annie, Seo, Seungmae, Solloa, Everardo Hegewisch, Mistretta, Brandon, Chatterjee, Sujash S., Gunaratne, Preethi, Allette, Kimaada, Wang, Ying-Chih, Smith, Melissa Laird, Sebra, Robert, Mace, Emily M., Horowitz, Amir, Thomson, Wendy, Martin, Paul, Eyre, Steve, Davis, Daniel M.

“…Human natural killer (NK) cells in peripheral blood perform many functions, and classification of specific subsets has been a longstanding goal. We report…”
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Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors by Kennedy, Philippa R, Barthen, Charlotte, Williamson, David J, Pitkeathly, William T E, Hazime, Khodor S, Cumming, Joshua, Stacey, Kevin B, Hilton, Hugo G, Carrington, Mary, Parham, Peter, Davis, Daniel M

“…Genetic diversity in human natural killer (NK) cell receptors is linked to resistance and susceptibility to many diseases. Here, we tested the effect of this…”
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The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling by Oszmiana, Anna, Williamson, David J., Cordoba, Shaun-Paul, Morgan, David J., Kennedy, Philippa R., Stacey, Kevin, Davis, Daniel M.

“…Super-resolution microscopy has revealed that immune cell receptors are organized in nanoscale clusters at cell surfaces and immune synapses. However,…”
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Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin by Byrne, Jennifer C, Ní Gabhann, Joan, Stacey, Kevin B, Coffey, Barbara M, McCarthy, Eoghan, Thomas, Warren, Jefferies, Caroline A

“…In addition to regulating B cell development and activation, Bruton's tyrosine kinase (Btk) functions downstream of multiple TLRs, including TLR7, to regulate…”
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Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC by O'Leary, Claire, Forte, Gabriella, Mitchell, Nadia L, Youshani, Amir Saam, Dyer, Adam, Wellby, Martin P, Russell, Katharina N, Murray, Samantha J, Jolinon, Nelly, Jones, Simon A, Stacey, Kevin, Davis, Daniel M, Henckaerts, Els, Palmer, David N, Kamaly-Asl, Ian, Bigger, Brian W

“…Mucopolysaccharidosis IIIC (MPSIIIC) is one of four Sanfilippo diseases sharing clinical symptoms of severe cognitive decline and shortened lifespan. The…”
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Genetics of SLE : Functional Relevance for Monocytes/Macrophages in Disease by Byrne, Jennifer C., Ní Gabhann, Joan, Lazzari, Elisa, Mahony, Rebecca, Smith, Siobhán, Stacey, Kevin, Wynne, Claire, Jefferies, Caroline A.

“…Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system…”
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Estrogen Receptor α Regulates Tripartite Motif–Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus by Smith, Siobhán, Ní Gabhann, Joan, McCarthy, Eoghan, Coffey, Barbara, Mahony, Rebecca, Byrne, Jennifer C., Stacey, Kevin, Ball, Elizabeth, Bell, Aubrey, Cunnane, Gaye, Doran, Michele F., Molloy, Eamonn S., Lee, Ruth Z., Harvey, Brian, Kearns, Grainne, Jefferies, Caroline A.

“…Objective To examine the role of 17β‐estradiol in the regulation of the autoantigen tripartite motif–containing protein 21 (TRIM‐21) in patients with systemic…”
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Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus by Smith, Siobhán, Gabhann, Joan Nı´, Higgs, Rowan, Stacey, Kevin, Wahren-Herlenius, Marie, Espinosa, Alexander, Totaro, Maria Grazia, Sica, Antonio, Ball, Elizabeth, Bell, Aubrey, Johnston, James, Browne, Peter, O'Neill, Lorraine, Kearns, Grainne, Jefferies, Caroline A.

“…Objective To examine the role of interferon regulatory factor 3 (IRF‐3) in the regulation of interleukin‐23 (IL‐23) production in patients with systemic lupus…”
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Defects in acute responses to TLR4 in Btk -deficient mice result in impaired dendritic cell-induced IFN-γ production by natural killer cells by Ní Gabhann, Joan, Spence, Shaun, Wynne, Claire, Smith, Siobhán, Byrne, Jennifer C, Coffey, Barbara, Stacey, Kevin, Kissenpfennig, Adrien, Johnston, Jim, Jefferies, Caroline A

“…Abstract This study defines a critical role for Btk in regulating TLR4-induced crosstalk between antigen presenting cells (APCs) and natural killer (NK) cells…”
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Estrogen Receptor [alpha] Regulates Tripartite Motif-Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus by Smith, Siobhán, Ni Gabhann, Joan, McCarthy, Eoghan, Coffey, Barbara, Mahony, Rebecca, Byrne, Jennifer C, Stacey, Kevin, Ball, Elizabeth, Bell, Aubrey, Cunnane, Gaye, Doran, Michele F, Molloy, Eamonn S, Lee, Ruth Z, Harvey, Brian, Kearns, Grainne, Jefferies, Caroline A

“…Objective To examine the role of 17[beta]-estradiol in the regulation of the autoantigen tripartite motif-containing protein 21 (TRIM-21) in patients with…”
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Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease by Jefferies, Caroline A., Stacey, Kevin, Smith, Siobhán, Mahony, Rebecca, Lazzari, Elisa, Ní Gabhann, Joan, Byrne, Jennifer C., Wynne, Claire

“…Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system…”
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Elderly slaves of the Plantation South: Somewhere between heaven and earth by Close, Stacey Kevin

“…The lives of the aged slaves in the antebellum South revealed a mosaic of complex and unique personalities. The image of the Uncle Remus, storytelling old…”
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