Viral Infection and Ischemic Stroke: Emerging Trends and Mechanistic Insights

Viral Infection and Ischemic Stroke: Emerging Trends and Mechanistic Insights

Population studies have suggested that viral infections may be contributing to risk of ischemic stroke, although the mechanisms for this are unclear. In this review, we examine the epidemiological evidence supporting the involvement of viral diseases, including influenza, COVID-19, chronic herpesvir...

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Bibliographic Details
Published in:Journal of the American Heart Association Vol. 13; no. 18; p. e035892
Main Authors: Clarke, Michael, Falcione, Sarina, Boghozian, Roobina, Todoran, Raluca, Zhang, Yiran, C Real, Maria Guadalupe, StPierre, Alexis, Joy, Twinkle, Jickling, Glen C
Format: Journal Article
Language:English
Published: England Wiley 17-09-2024
Subjects:
COVID-19 - complications
COVID-19 - epidemiology
Humans
Incidence
inflammation
ischemic stroke
Ischemic Stroke - epidemiology
Risk Factors
SARS-CoV-2
thrombosis
vasculopathy
virus
Virus Diseases - complications
Virus Diseases - epidemiology
virus host interactions
thrombosis
vasculopathy
inflammation
virus
ischemic stroke
virus host interactions
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Summary:Population studies have suggested that viral infections may be contributing to risk of ischemic stroke, although the mechanisms for this are unclear. In this review, we examine the epidemiological evidence supporting the involvement of viral diseases, including influenza, COVID-19, chronic herpesvirus infections, and hepatitis C in current trends of stroke incidence. To support these associations, we highlight the virus-host interactions that are critical in the context of stroke, including direct effects of acute and persistent viral infections on vascular function, inflammation, and thrombosis. Additionally, we evaluate the systemic changes that occur during viral infection that can predispose individuals to ischemic stroke, including alterations in blood pressure regulation, coagulation, and lipid metabolism. Our review emphasizes the need to further elucidate precise mechanisms involved in viral infections and stroke risk. Future research will inform the development of targeted interventions for stroke prevention in the context of viral diseases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.124.035892