Search Results - "St. Laurent, Chris D"

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands by Rodrigues, Emily, Jung, Jaesoo, Park, Heajin, Loo, Caleb, Soukhtehzari, Sepideh, Kitova, Elena N., Mozaneh, Fahima, Daskhan, Gour, Schmidt, Edward N., Aghanya, Vivian, Sarkar, Susmita, Streith, Laura, St. Laurent, Chris D., Nguyen, Linh, Julien, Jean-Philippe, West, Lori J., Williams, Karla C., Klassen, John S., Macauley, Matthew S.

“…Sialic acid-binding immunoglobulin-type lectins (Siglecs) are immunomodulatory receptors that are regulated by their glycan ligands. The connections between…”
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Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands by Jung, Jaesoo, Enterina, Jhon R, Bui, Duong T, Mozaneh, Fahima, Lin, Po-Han, Nitin, Kuo, Chu-Wei, Rodrigues, Emily, Bhattacherjee, Abhishek, Raeisimakiani, Parisa, Daskhan, Gour C, St. Laurent, Chris D, Khoo, Kay-Hooi, Mahal, Lara K, Zandberg, Wesley F, Huang, Xuefei, Klassen, John S, Macauley, Matthew S

“…The immunomodulatory family of Siglecs recognizes sialic acid-containing glycans as “self”, which is exploited in cancer for immune evasion. The biochemical…”
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Choroideremia by Dimopoulos, Ioannis S, Radziwon, Alina, St. Laurent, Chris D, MacDonald, Ian M

“…PURPOSE OF REVIEWAlthough much has been written to define the phenotype and genotype of choroideremia (CHM), research continues to provide new insights that…”
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Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice by Eskandari-Sedighi, Ghazaleh, Crichton, Madeline, Zia, Sameera, Gomez-Cardona, Erik, Cortez, Leonardo M, Patel, Zain H, Takahashi-Yamashiro, Kei, St Laurent, Chris D, Sidhu, Gaurav, Sarkar, Susmita, Aghanya, Vivian, Sim, Valerie L, Tan, Qiumin, Julien, Olivier, Plemel, Jason R, Macauley, Matthew S

“…Microglia play diverse pathophysiological roles in Alzheimer's disease (AD), with genetic susceptibility factors skewing microglial cell function to influence…”
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Repression of phagocytosis by human CD33 is not conserved with mouse CD33 by Bhattacherjee, Abhishek, Rodrigues, Emily, Jung, Jaesoo, Luzentales-Simpson, Matthew, Enterina, Jhon R., Galleguillos, Danny, St. Laurent, Chris D., Nakhaei-Nejad, Maryam, Fuchsberger, Felix F., Streith, Laura, Wang, Qian, Kawasaki, Norihito, Duan, Shiteng, Bains, Arjun, Paulson, James C., Rademacher, Christoph, Giuliani, Fabrizio, Sipione, Simonetta, Macauley, Matthew S.

“…CD33 is an immunomodulatory receptor linked to Alzheimer’s disease (AD) susceptibility via regulation of phagocytosis in microglia. Divergent features between…”
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Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury by Dooley, James L, Abdel-Latif, Dalia, St Laurent, Chris D, Puttagunta, Lakshmi, Befus, Dean, Lacy, Paige

“…Acute lung injury (ALI) is an inflammatory disorder associated with recruitment and activation of neutrophils in lungs. Rac2, a member of the Rho GTPase…”
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Expression of nitric oxide synthases in leukocytes in nasal polyps by Yoshimura, Tsuyoshi, MD, Moon, Tae Chul, PhD, St. Laurent, Chris D., BSc, Puttagunta, Lakshmi, MD, Chung, Kerri, MD, Wright, Erin, MD, Yoshikawa, Mamoru, MD, Moriyama, Hiroshi, MD, Befus, A. Dean, PhD

“…Abstract Background Nitric oxide (NO) has various roles in airway physiology and pathophysiology. Monitoring exhaled NO levels is increasingly common to…”
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Disrupting Protein Expression with Double-Clicked sgRNA–Cas9 Complexes: A Modular Approach to CRISPR Gene Editing by Tijaro-Bulla, Santiago, Osman, Eiman A., St Laurent, Chris D., McCord, Kelli A., Macauley, Matthew S., Gibbs, Julianne M.

“…CRISPR-Cas9 is currently the most versatile technique to perform gene editing in living organisms. In this approach, the Cas9 endonuclease is guided toward its…”
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The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia by Bhattacherjee, Abhishek, Jung, Jaesoo, Zia, Sameera, Ho, Madelene, Eskandari-Sedighi, Ghazaleh, St. Laurent, Chris D., McCord, Kelli A., Bains, Arjun, Sidhu, Gaurav, Sarkar, Susmita, Plemel, Jason R., Macauley, Matthew S.

“…Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the…”
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Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif by St Laurent, Chris D, St Laurent, Katherine E, Mathison, Ron D, Befus, A Dean

“…Salivary glands are involved in the production and exocrine and endocrine secretion of biologically active proteins, polypeptides, and hormones involved in…”
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A novel biomarker associated with distress in humans: calcium-binding protein, spermatid-specific 1 (CABS1) by Ritz, Thomas, Rosenfield, David, St Laurent, Chris D, Trueba, Ana F, Werchan, Chelsey A, Vogel, Pia D, Auchus, Richard J, Reyes-Serratos, Eduardo, Befus, A Dean

“…Calcium-binding protein spermatid-specific 1 (CABS1) is expressed in the human submandibular gland and has an anti-inflammatory motif similar to that in…”
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Molecular Insights into O‑Linked Sialoglycans Recognition by the Siglec-Like SLBR‑N (SLBRUB10712) of Streptococcus gordonii by Di Carluccio, Cristina, Cerofolini, Linda, Moreira, Miguel, Rosu, Frédéric, Padilla-Cortés, Luis, Gheorghita, Giulia Roxana, Xu, Zhuojia, Santra, Abhishek, Yu, Hai, Yokoyama, Shinji, Gray, Taylor E., St. Laurent, Chris D., Manabe, Yoshiyuki, Chen, Xi, Fukase, Koichi, Macauley, Matthew S., Molinaro, Antonio, Li, Tiehai, Bensing, Barbara A., Marchetti, Roberta, Gabelica, Valérie, Fragai, Marco, Silipo, Alba

“…Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the human oral cavity, but can also cause local or systemic diseases…”
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Limited replication of influenza A virus in human mast cells by Marcet, Candy W., St. Laurent, Chris D., Moon, Tae Chul, Singh, Nav, Befus, A. Dean

“…Mast cells are important in innate immunity and protective against certain bacterial infections. However, there is limited evidence that mast cells respond to…”
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Metabolomic profiling of bronchoalveolar lavage fluids by isotope labeling liquid chromatography mass spectrometry: a promising approach to studying experimental asthma by Peng, Jun, St. Laurent, Chris D., Befus, A. Dean, Zhou, Ruokun, Li, Liang

“…Metabolomic analysis of bronchoalveolar lavage fluid (BALF) may help understand the pathophysiology of pulmonary diseases such as asthma. However, a major…”
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Measurement of nitric oxide in mast cells with the fluorescent indicator DAF-FM diacetate by St Laurent, Chris D, Moon, Tae Chul, Befus, A Dean

“…The production of nitric oxide in mast cells has been difficult to measure due to the low amounts made by mast cells, as well as limitations in the specificity…”
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Author Correction: Repression of phagocytosis by human CD33 is not conserved with mouse CD33 by Bhattacherjee, Abhishek, Rodrigues, Emily, Jung, Jaesoo, Luzentales-Simpson, Matthew, Enterina, Jhon R., Galleguillos, Danny, St. Laurent, Chris D., Nakhaei-Nejad, Maryam, Fuchsberger, Felix F., Streith, Laura, Wang, Qian, Kawasaki, Norihito, Duan, Shiteng, Bains, Arjun, Paulson, James C., Rademacher, Christoph, Giuliani, Fabrizio, Sipione, Simonetta, Macauley, Matthew S.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Increasing phagocytosis of microglia by targeting CD33 with liposomes displaying glycan ligands by Bhattacherjee, Abhishek, Daskhan, Gour C., Bains, Arjun, Watson, Adrianne E.S., Eskandari-Sedighi, Ghazaleh, St. Laurent, Chris D., Voronova, Anastassia, Macauley, Matthew S.

“…CD33 is an immunomodulatory receptor expressed by microglia and genetically linked to Alzheimer's disease (AD) susceptibility. While antibodies targeting CD33…”
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CRISPR-Click Enables Dual-Gene Editing with Modular Synthetic sgRNAs by Park, Hansol, Osman, Eiman A., Cromwell, Christopher R., St Laurent, Chris D., Liu, Yuning, Kitova, Elena N., Klassen, John S., Hubbard, Basil P., Macauley, Matthew S., Gibbs, Julianne M.

“…Gene-editing systems such as CRISPR-Cas9 readily enable individual gene phenotypes to be studied through loss of function. However, in certain instances, gene…”
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Responses of human mast cells and epithelial cells following exposure to influenza A virus by Ng, Kurtis, Raheem, Javeria, St Laurent, Chris D., Marcet, Candy Tsang, Vliagoftis, Harissios, Befus, A. Dean, Moon, Tae Chul

“…As a part of innate immune defense, the role of mast cells during viral replication has been incompletely understood. In this study, we characterized and…”
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PEX6 Mutations in Peroxisomal Biogenesis Disorders: An Usher Syndrome Mimic by Benson, Matthew D, Papp, Kimberly M, Casey, Geoffrey A, Radziwon, Alina, St Laurent, Chris D, Doucette, Lance P, MacDonald, Ian M

“…PurposePeroxisomal biogenesis disorders (PBDs) represent a spectrum of conditions that result in vision loss, sensorineural hearing loss, neurologic…”
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