Search Results - "St. Hilaire, Cynthia"

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice by Gomez, Delphine, Baylis, Richard A., Durgin, Brittany G., Newman, Alexandra A. C., Alencar, Gabriel F., Mahan, Sidney, St. Hilaire, Cynthia, Müller, Werner, Waisman, Ari, Francis, Sheila E., Pinteaux, Emmanuel, Randolph, Gwendalyn J., Gram, Hermann, Owens, Gary K.

“…Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis…”
Get full text

Lnc’ing Metabolic Regulation of Epigenetic Modifications to Atherosclerotic Calcification by Cuevas, Rolando A., St. Hilaire, Cynthia

Get full text

TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling by Cooley, Brian C, Nevado, Jose, Mellad, Jason, Yang, Dan, St Hilaire, Cynthia, Negro, Alejandra, Fang, Fang, Chen, Guibin, San, Hong, Walts, Avram D, Schwartzbeck, Robin L, Taylor, Brandi, Lanzer, Jan D, Wragg, Andrew, Elagha, Abdalla, Beltran, Leilani E, Berry, Colin, Feil, Robert, Virmani, Renu, Ladich, Elena, Kovacic, Jason C, Boehm, Manfred

“…Veins grafted into an arterial environment undergo a complex vascular remodeling process. Pathologic vascular remodeling often results in stenosed or occluded…”
Get more information

NT5E Mutations and Arterial Calcifications by St. Hilaire, Cynthia, Ziegler, Shira G, Markello, Thomas C, Brusco, Alfredo, Groden, Catherine, Gill, Fred, Carlson-Donohoe, Hannah, Lederman, Robert J, Chen, Marcus Y, Yang, Dan, Siegenthaler, Michael P, Arduino, Carlo, Mancini, Cecilia, Freudenthal, Bernard, Stanescu, Horia C, Zdebik, Anselm A, Chaganti, R. Krishna, Nussbaum, Robert L, Kleta, Robert, Gahl, William A, Boehm, Manfred

“…Members of three families were noted to have extensive arterial and joint calcifications. Genetic analysis identified mutations in NT5E , encoding CD73, which…”
Get full text

Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC by Jin, Hui, St Hilaire, Cynthia, Huang, Yuting, Yang, Dan, Dmitrieva, Natalia I, Negro, Alejandra, Schwartzbeck, Robin, Liu, Yangtengyu, Yu, Zhen, Walts, Avram, Davaine, Jean-Michel, Lee, Duck-Yeon, Donahue, Danielle, Hsu, Kevin S, Chen, Jessica, Cheng, Tao, Gahl, William, Chen, Guibin, Boehm, Manfred

“…ACDC (arterial calcification due to deficiency of CD73) is an autosomal recessive disease resulting from loss-of-function mutations in NT5E, which encodes…”
Get more information

Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence by Li, Yao, Kračun, Damir, Dustin, Christopher M., Massry, Mohamed El, Yuan, Shuai, Goossen, Christian J., DeVallance, Evan R., Sahoo, Sanghamitra, Hilaire, Cynthia St, Gurkar, Aditi U., Finkel, Toren, Straub, Adam C., Cifuentes-Pagano, Eugenia, Pagano, Patrick J.

“…In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators…”
Get full text

Mast cell activation and degranulation in acute artery injury: A target for post‐operative therapy by Harper, Rebecca L., Fang, Fang, San, Hong, Negro, Alejandra, St. Hilaire, Cynthia, Yang, Dan, Chen, Guibin, Yu, Zhen, Dmitrieva, Natalia I., Lanzer, Jan, Davaine, Jean‐Michel, Schwartzbeck, Robin, Walts, Avram D., Kovacic, Jason C., Boehm, Manfred

“…The increasing incidence of cardiovascular disease (CVD) has led to a significant ongoing need to address this surgically through coronary artery bypass…”
Get full text

Cell Phenotype Transitions in Cardiovascular Calcification by Hortells, Luis, Sur, Swastika, St Hilaire, Cynthia

“…Cardiovascular calcification was originally considered a passive, degenerative process, however with the advance of cellular and molecular biology techniques…”
Get full text

PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1 by Kant, Shashi, Tran, Khanh-Van, Kvandova, Miroslava, Caliz, Amada D., Yoo, Hyung-Jin, Learnard, Heather, Dolan, Ana C., Craige, Siobhan M., Hall, Joshua D., Jiménez, Juan M., St. Hilaire, Cynthia, Schulz, Eberhard, Kröller-Schön, Swenja, Keaney, John F.

“…Fluid shear stress (FSS) is known to mediate multiple phenotypic changes in the endothelium. Laminar FSS (undisturbed flow) is known to promote endothelial…”
Get full text

Ecto-5'-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction by Cuevas, Rolando A, Wong, Ryan, Joolharzadeh, Pouya, Moorhead, 3rd, William J, Chu, Claire C, Callahan, 4th, Jack, Crane, Alex, Boufford, Camille K, Parise, Angelina M, Parwal, Aneesha, Behzadi, Parya, St Hilaire, Cynthia

“…Arterial calcification due to deficiency of CD73 (ACDC) is a rare genetic disease caused by a loss-of-function mutation in the gene encoding the…”
Get more information

Catching a Disease: A Molecular Trap as a Therapy for Pulmonary Arterial Hypertension by Roman, Beth L, St Hilaire, Cynthia

Get full text

Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress by Kroll, Rachel G, Powell, Corey, Chen, Jun, Snider, Natasha T, St Hilaire, Cynthia, Reddy, Akshay, Kim, Judy, Pinsky, David J, Murthy, Venkatesh L, Sutton, Nadia R

“…Background Ectonucleotidases maintain vascular homeostasis by metabolizing extracellular nucleotides, modulating inflammation and thrombosis, and potentially,…”
Get full text

Medial Arterial Calcification: A Significant and Independent Contributor of Peripheral Artery Disease by St Hilaire, Cynthia

“…Over 200 million individuals worldwide are estimated to have peripheral artery disease (PAD). Although the term peripheral can refer to any outer branch of the…”
Get full text

Bidirectional Translation in Cardiovascular Calcification by St. Hilaire, Cynthia, Liberman, Marcel, Miller, Jordan D

Get full text

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5 by Carlsten, Mattias, Namazi, Ali, Reger, Robert, Levy, Emily, Berg, Maria, St. Hilaire, Cynthia, Childs, Richard W.

“…Although the proteasome inhibitor bortezomib has significantly improved the survival of patients with multiple myeloma (MM), the disease remains fatal as most…”
Get full text

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis by Nguyen, Hao G, Makitalo, Maria, Yang, Dan, Chinnappan, Dharmaraj, St. Hilaire, Cynthia, Ravid, Katya

“…High expression of Aurora-B has been observed in various cancers, and inhibition of this kinase has been shown to halt cellular proliferation. However, the…”
Get full text

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion by Yang, Dan, Zhang, Ying, Nguyen, Hao G, Koupenova, Milka, Chauhan, Anil K, Makitalo, Maria, Jones, Matthew R, St Hilaire, Cynthia, Seldin, David C, Toselli, Paul, Lamperti, Edward, Schreiber, Barbara M, Gavras, Haralambos, Wagner, Denisa D, Ravid, Katya

“…Adenosine has been described as playing a role in the control of inflammation, but it has not been certain which of its receptors mediate this effect. Here, we…”
Get full text

Editorial: Comorbidities and Aortic Valve Stenosis: Molecular Mechanism, Risk Factors and Novel Therapeutic Options by St Hilaire, Cynthia, Jansen, Felix, Goettsch, Claudia

Get full text

Mechanisms of induction of adenosine receptor genes and its functional significance by St. Hilaire, Cynthia, Carroll, Shannon H., Chen, Hongjie, Ravid, Katya

“…Adenosine is a metabolite generated and released from cells, particularly under injury or stress. It elicits protective or damaging responses via signaling…”
Get full text

Isolation of Human Primary Valve Cells for In vitro Disease Modeling by Cuevas, Rolando A, Chu, Claire C, Moorhead, 3rd, William J, Wong, Ryan, Sultan, Ibrahim, St Hilaire, Cynthia

“…Calcific aortic valve disease (CAVD) is present in nearly a third of the elderly population. Thickening, stiffening, and calcification of the aortic valve…”
Get more information