Search Results - "St. Lawrence, Keith"
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A multi-centre evaluation of eleven clinically feasible brain PET/MRI attenuation correction techniques using a large cohort of patients
Published in NeuroImage (Orlando, Fla.) (15-02-2017)“…To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal…”
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A Noninvasive Method for Quantifying Cerebral Blood Flow by Hybrid PET/MRI
Published in Journal of Nuclear Medicine (01-08-2018)“…Although PET with O-water is the gold standard for imaging cerebral blood flow (CBF), quantification requires measuring the arterial input function (AIF),…”
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Assessing cerebral blood flow, oxygenation and cytochrome c oxidase stability in preterm infants during the first 3 days after birth
Published in Scientific reports (07-01-2022)“…A major concern with preterm birth is the risk of neurodevelopmental disability. Poor cerebral circulation leading to periods of hypoxia is believed to play a…”
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caliPER: A software for blood-free parametric Patlak mapping using PET/MRI input function
Published in NeuroImage (Orlando, Fla.) (01-08-2022)“…•caliPER is an adaptable image processing software for extracting image-derived input functions and generating parametric maps of irreversible PET tracer…”
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Turbo-FLASH based arterial spin labeled perfusion MRI at 7 T
Published in PloS one (20-06-2013)“…Motivations of arterial spin labeling (ASL) at ultrahigh magnetic fields include prolonged blood T1 and greater signal-to-noise ratio (SNR). However, increased…”
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Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism
Published in Neurophotonics (Print) (01-10-2020)“…Significance: Near-infrared spectroscopy (NIRS) combined with diffuse correlation spectroscopy (DCS) provides a noninvasive approach for monitoring cerebral…”
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Simultaneous monitoring of cerebral perfusion and cytochrome c oxidase by combining broadband near-infrared spectroscopy and diffuse correlation spectroscopy
Published in Biomedical optics express (01-06-2018)“…Preterm infants born with very low birth weights are at a high risk of brain injury, in part because the premature brain is believed to be prone to periods of…”
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A two-stage approach for measuring vascular water exchange and arterial transit time by diffusion-weighted perfusion MRI
Published in Magnetic resonance in medicine (01-05-2012)“…Changes in the exchange rate of water across the blood‐brain barrier, denoted kw, may indicate blood‐brain barrier dysfunction before the leakage of…”
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Time-resolved subtraction method for measuring optical properties of turbid media
Published in Applied optics. Optical technology and biomedical optics (01-03-2016)“…Near-infrared spectroscopy is a noninvasive optical method used primarily to monitor tissue oxygenation due to the absorption properties of hemoglobin…”
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Sensitivity of Arterial Spin Labeling for Characterization of Longitudinal Perfusion Changes in Frontotemporal Dementia and Related Disorders
Published in NeuroImage clinical (01-01-2022)“…•This study demonstrates the value of ASL for longitudinal monitoring of perfusion in FTD patients.•Good agreement was found in repeat measures of CBF in…”
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The functional and structural associations of aberrant microglial activity in major depressive disorder
Published in Journal of psychiatry & neuroscience (01-05-2022)“…Major depressive disorder (MDD) is a debilitating mental illness that has been linked to increases in markers of inflammation, as well as to changes in brain…”
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Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy
Published in Journal of biomedical optics (01-02-2013)“…Preterm infants are highly susceptible to ischemic brain injury; consequently, continuous bedside monitoring to detect ischemia before irreversible damage…”
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Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation
Published in Brain sciences (15-07-2020)“…Post-hemorrhagic ventricular dilatation (PHVD) is characterized by a build-up of cerebral spinal fluid (CSF) in the ventricles, which increases intracranial…”
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The Quest of Characterizing Hemodynamic Failure in Patients With Cerebrovascular Disease
Published in Journal of the American Heart Association (19-12-2023)Get full text
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Altered resting-state functional connectivity in newborns with hypoxic ischemic encephalopathy assessed using high-density functional near-infrared spectroscopy
Published in Scientific reports (07-02-2024)“…Hypoxic-ischemic encephalopathy (HIE) results from a lack of oxygen to the brain during the perinatal period. HIE can lead to mortality and various acute and…”
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Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension
Published in Neurophotonics (Print) (01-04-2023)“…Combining diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) permits simultaneous monitoring of multiple cerebral hemodynamic…”
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Quantification of joint blood flow by dynamic contrast-enhanced near-infrared spectroscopy: application to monitoring disease activity in a rat model of rheumatoid arthritis
Published in Journal of biomedical optics (01-01-2020)“…Significance: Current guidelines for rheumatoid arthritis (RA) management recommend early treatment with disease modifying antirheumatic drugs (DMARDs)…”
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Water Exchange across the Blood-Brain Barrier in Obstructive Sleep Apnea: An MRI Diffusion-Weighted Pseudo-Continuous Arterial Spin Labeling Study
Published in Journal of neuroimaging (01-11-2015)“…ABSTRACT BACKGROUND AND PURPOSE Obstructive sleep apnea (OSA) subjects show brain injury in sites that control autonomic, cognitive, and mood functions that…”
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Effects of Systemic Physiology on Mapping Resting-State Networks Using Functional Near-Infrared Spectroscopy
Published in Frontiers in neuroscience (08-03-2022)“…Resting-state functional connectivity (rsFC) has gained popularity mainly due to its simplicity and potential for providing insights into various brain…”
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Mapping Long-Term Functional Changes in Cerebral Blood Flow by Arterial Spin Labeling
Published in PloS one (05-10-2016)“…Although arterial spin labeling (ASL) is appealing for mapping long-term changes in functional activity, inter-sessional variations in basal blood flow,…”
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