Search Results - "St John, E"

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds by Báez-Santos, Yahira M., St. John, Sarah E., Mesecar, Andrew D.

“…•HTS and structure-based design produced naphthalene-based lead compounds with inhibition of SARS-CoV PLpro in the nM range.•These naphthalene-based lead…”
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Phenotypic covariation predicts diversification in an adaptive radiation of pupfishes by Dunker, Julia C., St. John, Michelle E., Martin, Christopher H.

“…Phenotypic covariation among suites of traits may constrain or promote diversification both within and between species, yet few studies have empirically tested…”
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Parallel evolution of integrated craniofacial traits in trophic specialist pupfishes by St. John, Michelle E., Dunker, Julia C., Richards, Emilie J., Romero, Stephanie, Martin, Christopher H.

“…Populations may adapt to similar environments via parallel or non‐parallel genetic changes, but the frequency of these alternative mechanisms and underlying…”
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Patient‐level costs in margin re‐excision for breast‐conserving surgery by Grant, Y., Al‐Khudairi, R., St John, E., Barschkett, M., Cunningham, D., Al‐Mufti, R., Hogben, K., Thiruchelvam, P., Hadjiminas, D. J., Darzi, A., Carter, A. W., Leff, D. R.

“…Background High rates of reoperation following breast‐conserving surgery (BCS) for positive margins are associated with costs to healthcare providers. The aim…”
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Self-Propelled Dressings Containing Thrombin and Tranexamic Acid Improve Short-Term Survival in a Swine Model of Lethal Junctional Hemorrhage by Baylis, James R, St. John, Alexander E, Wang, Xu, Lim, Esther B, Statz, Matthew L, Chien, Diana, Simonson, Eric, Stern, Susan A, Liggins, Richard T, White, Nathan J, Kastrup, Christian J

“…ABSTRACTHemorrhage is the leading cause of preventable death in trauma, and hemorrhage from noncompressible junctional anatomic sites is particularly difficult…”
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Role of trauma team activation in poor outcomes of elderly patients by St. John, Alexander E., MD, MS, Rowhani-Rahbar, Ali, MD, MPH, PhD, Arbabi, Saman, MD, MPH, Bulger, Eileen M., MD

“…Abstract Introduction Elderly trauma patients suffer worse outcomes than younger patients. Trauma team activation (TTA) improves outcomes in younger patients…”
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Exploration of chest wall perforator vascular anatomy on standard breast MRI: A potential aid to chest wall perforator flap planning by Heeney, A., Bhaludin, B., St John, E.R., O'Connell, R., Krupa, K., Rusby, J.E., Allen, S., Barry, P.A.

“…Local chest wall perforator flaps (CWPFs) are a volume replacement technique permitting breast-conserving surgery in patients who otherwise may require a…”
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Positive Inotropic and Lusitropic Effects of HNO/NO-in Failing Hearts: Independence from β-Adrenergic Signaling by Paolocci, Nazareno, Katori, Tatsuo, Champion, Hunter C., St. John, Marcus E., Miranda, Katrina M., Fukuto, Jon M., Wink, David A., Kass, David A.

“…Nitroxyl anion (HNO/NO-), the one-electron reduced form of nitric oxide (NO), induces positive cardiac inotropy and selective venodilation in the normal in…”
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Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2 by St. John, Sarah E., Jensen, Katherine C., Kang, SooSung, Chen, Yafang, Calamini, Barbara, Mesecar, Andrew D., Lipton, Mark A.

“…Resveratrol (3,5,4′-trihydroxylstilbene) has been proposed to elicit a variety of positive health effects including protection against cancer and…”
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How to Investigate the Origins of Novelty: Insights Gained from Genetic, Behavioral, and Fitness Perspectives by Martin, C H, McGirr, J A, Richards, E J, St John, M E

“…Biologists are drawn to the most extraordinary adaptations in the natural world, often referred to as evolutionary novelties, yet rarely do we understand the…”
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Rediscovering the wound hematoma as a site of hemostasis during major arterial hemorrhage by White, N. J., Mehic, E., Wang, X., Chien, D., Lim, E., St. John, A. E., Stern, S. A., Mourad, P. D., Rieger, M., Fries, D., Martinowitz, U.

“…Summary Background Treatments for major internal bleeding after injury include permissive hypotension to decrease the rate of blood loss, intravenous infusion…”
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Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS by Tomar, Sakshi, Johnston, Melanie L, St John, Sarah E, Osswald, Heather L, Nyalapatla, Prasanth R, Paul, Lake N, Ghosh, Arun K, Denison, Mark R, Mesecar, Andrew D

“…All coronaviruses, including the recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV) from the β-CoV subgroup, require the proteolytic…”
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Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart by Saavedra, Walter F, Paolocci, Nazareno, St. John, Marcus E, Skaf, Michel W, Stewart, Garrick C, Xie, Jin-Sheng, Harrison, Robert W, Zeichner, Joshua, Mudrick, Daniel, Marbán, Eduardo, Kass, David A, Hare, Joshua M

“…Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an unknown mechanism. We hypothesized that this energetic effect is due to…”
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Prehospital Lactate Predicts Need for Resuscitative Care in Non-hypotensive Trauma Patients by St John, Alexander E, McCoy, Andrew M, Moyes, Allison G, Guyette, Francis X, Bulger, Eileen M, Sayre, Michael R

“…The prehospital decision of whether to triage a patient to a trauma center can be difficult. Traditional decision rules are based heavily on vital sign…”
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Rapid adaptive evolution of scale-eating kinematics to a novel ecological niche by St John, Michelle E, Holzman, Roi, Martin, Christopher H

“…The origins of novel trophic specialization, in which organisms begin to exploit resources for the first time, may be explained by shifts in behavior such as…”
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Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS) by St. John, Sarah E., Tomar, Sakshi, Stauffer, Shaun R., Mesecar, Andrew D.

“…[Display omitted] The bat coronavirus HKU4 belongs to the same 2c lineage as that of the deadly Middle East Respiratory Syndrome coronavirus (MERS-CoV) and…”
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Leukocyte activation primes fibrinogen for proteolysis by mitochondrial oxidative stress by Han, Chang Yeop, Pichon, Trey J., Wang, Xu, Ringgold, Kristyn M., St John, Alexander E., Stern, Susan A., White, Nathan J.

“…Critical illness leads to rapid fibrinogen consumption, hyperfibrinolysis, and coagulopathy that exacerbates bleeding and increases mortality. Immune cell…”
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Oral shelling within an adaptive radiation of pupfishes: Testing the adaptive function of a novel nasal protrusion and behavioural preference by St. John, Michelle E., Dixon, Kristi E., Martin, Christopher H.

“…Dietary specialization on hard prey items, such as mollusks and crustaceans, is commonly observed in a diverse array of fish species. Many fish consume these…”
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A novel melanocortin fusion protein inhibits fibrinogen oxidation and degradation during trauma-induced coagulopathy by Han, Chang Yeop, Wang, Xu, Ringgold, Kristyn M, Bennett, Jennifer C, St John, Alexander E, Berenson, Ronald, Stern, Susan A, White, Nathan J

“…Immune cell inflammation is implicated in the pathophysiology of acute trauma-induced coagulopathy (TIC). We hypothesized that leukocyte inflammation…”
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A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation by Kollef, Marin H, Shapiro, Steven D, Silver, Patricia, St. John, Robert E, Prentice, Donna, Sauer, Sharon, Ahrens, Tom S, Shannon, William, Baker-Clinkscale, Darnetta

“…OBJECTIVE To compare a practice of protocol-directed weaning from mechanical ventilation implemented by nurses and respiratory therapists with traditional…”
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