Search Results - "St Claire, Jason"

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches by Pinto, Ricardo Mouro, Dragileva, Ella, Kirby, Andrew, Lloret, Alejandro, Lopez, Edith, St Claire, Jason, Panigrahi, Gagan B, Hou, Caixia, Holloway, Kim, Gillis, Tammy, Guide, Jolene R, Cohen, Paula E, Li, Guo-Min, Pearson, Christopher E, Daly, Mark J, Wheeler, Vanessa C

“…The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may…”
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Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver by Lee, Jong-Min, Pinto, Ricardo Mouro, Gillis, Tammy, St Claire, Jason C, Wheeler, Vanessa C

“…Age at onset of Huntington's disease (HD) is largely determined by the CAG trinucleotide repeat length in the HTT gene. Importantly, the CAG repeat undergoes…”
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Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice by Kovalenko, Marina, Dragileva, Ella, St Claire, Jason, Gillis, Tammy, Guide, Jolene R, New, Jaclyn, Dong, Hualing, Kucherlapati, Raju, Kucherlapati, Melanie H, Ehrlich, Michelle E, Lee, Jong-Min, Wheeler, Vanessa C

“…The CAG trinucleotide repeat mutation in the Huntington's disease gene (HTT) exhibits age-dependent tissue-specific expansion that correlates with disease…”
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High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds by Ament, Seth A, Pearl, Jocelynn R, Grindeland, Andrea, St Claire, Jason, Earls, John C, Kovalenko, Marina, Gillis, Tammy, Mysore, Jayalakshmi, Gusella, James F, Lee, Jong-Min, Kwak, Seung, Howland, David, Lee, Min Young, Baxter, David, Scherler, Kelsey, Wang, Kai, Geman, Donald, Carroll, Jeffrey B, MacDonald, Marcy E, Carlson, George, Wheeler, Vanessa C, Price, Nathan D, Hood, Leroy E

“…Huntington's disease is a dominantly inherited neurodegenerative disease caused by the expansion of a CAG repeat in the HTT gene. In addition to the length of…”
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Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice by Kovalenko, Marina, Erdin, Serkan, Andrew, Marissa A, St Claire, Jason, Shaughnessey, Melissa, Hubert, Leroy, Neto, João Luís, Stortchevoi, Alexei, Fass, Daniel M, Mouro Pinto, Ricardo, Haggarty, Stephen J, Wilson, John H, Talkowski, Michael E, Wheeler, Vanessa C

“…Somatic expansion of the Huntington's disease (HD) CAG repeat drives the rate of a pathogenic process ultimately resulting in neuronal cell death. Although…”
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HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction by Kovalenko, Marina, Milnerwood, Austen, Giordano, James, St Claire, Jason, Guide, Jolene R, Stromberg, Mary, Gillis, Tammy, Sapp, Ellen, DiFiglia, Marian, MacDonald, Marcy E, Carroll, Jeffrey B, Lee, Jong-Min, Tappan, Susan, Raymond, Lynn, Wheeler, Vanessa C

“…Successful disease-modifying therapy for Huntington's disease (HD) will require therapeutic intervention early in the pathogenic process. Achieving this goal…”
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Chromosome substitution strain assessment of a Huntington’s disease modifier locus by Ramos, Eliana Marisa, Kovalenko, Marina, Guide, Jolene R., St. Claire, Jason, Gillis, Tammy, Mysore, Jayalakshmi S., Sequeiros, Jorge, Wheeler, Vanessa C., Alonso, Isabel, MacDonald, Marcy E.

“…Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans…”
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Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches: e1003930 by Pinto, Ricardo Mouro, Dragileva, Ella, Kirby, Andrew, Lloret, Alejandro, Lopez, Edith, Claire, Jason St, Panigrahi, Gagan B, Hou, Caixia, Holloway, Kim, Gillis, Tammy, Guide, Jolene R, Cohen, Paula E, Li, Guo-Min, Pearson, Christopher E, Daly, Mark J, Wheeler, Vanessa C

“…The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may…”
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