Search Results - "Stępniak, Jan"

Protective Effects of Melatonin against Carcinogen-Induced Oxidative Damage in the Thyroid by Stępniak, Jan, Karbownik-Lewińska, Małgorzata

“…Melatonin, primarily synthesized in the pineal gland, plays a crucial role in regulating circadian rhythms and possesses significant antioxidative properties…”
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Iodine as a potential endocrine disruptor—a role of oxidative stress by Karbownik-Lewińska, Małgorzata, Stępniak, Jan, Iwan, Paulina, Lewiński, Andrzej

“…Purpose Iodine is an essential micronutrient required for thyroid hormone biosynthesis. However, overtreatment with iodine can unfavorably affect thyroid…”
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Melatonin and Indole-3-Propionic Acid Reduce Oxidative Damage to Membrane Lipids Induced by High Iron Concentrations in Porcine Skin by Rynkowska, Aleksandra, Stępniak, Jan, Karbownik-Lewińska, Małgorzata

“…Iron excess in tissues results in increased oxidative damage. Among different tissues, the skin can particularly be severely damaged by oxidative stress, as it…”
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17β-Estradiol Stimulates Oxidative Stress Components and Thyroid Specific Genes in Porcine Thyroid Follicular Cells: Potential Differences Between Sexes by Stępniak, Jan, Karbownik-Lewińska, Małgorzata

“…17β-estradiol plays a crucial role in regulating cellular processes in both reproductive and non-reproductive tissues, including the thyroid gland. It…”
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Fenton Reaction-Induced Oxidative Damage to Membrane Lipids and Protective Effects of 17β-Estradiol in Porcine Ovary and Thyroid Homogenates by Rynkowska, Aleksandra, Stępniak, Jan, Karbownik-Lewińska, Małgorzata

“…The Fenton reaction (Fe +H O →Fe + OH+OH ) results in strong oxidative damage to macromolecules when iron (Fe) or hydrogen peroxide (H O ) are in excess. This…”
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Indole-3-Butyric Acid, a Natural Auxin, Protects against Fenton Reaction-Induced Oxidative Damage in Porcine Thyroid by Skoczyńska, Anna K, Gładysz, Aleksandra K, Stępniak, Jan, Karbownik-Lewińska, Małgorzata

“…We present results on the potential protective antioxidant properties of indole-3-butyric acid. Indole-3-butyric acid is an indole derivative defined as an…”
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Decreased mannan-binding lectin level in adults with hypopituitarism; dependence on appropriate hormone replacement therapies by Matusiak, Aleksandra E, Stępniak, Jan, Lewiński, Andrzej, Karbownik-Lewińska, Małgorzata

“…Mannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Although there are some studies showing links between endocrine…”
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Sorafenib versus Lenvatinib Causes Stronger Oxidative Damage to Membrane Lipids in Noncancerous Tissues of the Thyroid, Liver, and Kidney: Effective Protection by Melatonin and Indole-3-Propionic Acid by Stępniak, Jan, Krawczyk-Lipiec, Joanna, Lewiński, Andrzej, Karbownik-Lewińska, Małgorzata

“…Sorafenib and lenvatinib are multi-targeted tyrosine kinase inhibitors which are currently approved to treat advanced hepatocellular carcinoma, renal cell…”
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Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid by Gładysz, Aleksandra K, Stępniak, Jan, Karbownik-Lewińska, Małgorzata

“…The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which…”
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The Protective Effect of Exogenous 17β-Estradiol against Experimentally Induced Oxidative Damage to Membrane Lipids Is Stronger in Male vs. Female Porcine Thyroids: Preliminary Results by Stępniak, Jan, Koziróg, Edward, Karbownik-Lewińska, Małgorzata

“…It is well-known that thyroid diseases are more prevalent in women than in men. The contribution of sex hormones may explain such disparity. The aim of this…”
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Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH-Retrospective Study by Karbownik-Lewińska, Małgorzata, Stępniak, Jan, Żurawska, Anna, Lewiński, Andrzej

“…High-normal TSH can be associated with metabolic abnormalities and infertility. Aims of this study are to analyze retrospectively if routinely measured blood…”
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Membrane Lipids in the Thyroid Comparing to Those in Non-Endocrine Tissues Are Less Sensitive to Pro-Oxidative Effects of Fenton Reaction Substrates by Stępniak, Jan, Rynkowska, Aleksandra, Karbownik-Lewińska, Małgorzata

“…Iron is an essential microelement for the proper functioning of many organs, among others it is required for thyroid hormone synthesis. However, its overload…”
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Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age—Results from Retrospective Analysis by Karbownik-Lewińska, Małgorzata, Stępniak, Jan, Lewiński, Andrzej

“…Isolated hypothyroxinemia (IH) unfavorably affects reproduction. This study aimed to evaluate retrospectively if any routinely measured clinical/laboratory…”
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Membrane lipids and nuclear DNA are differently susceptive to Fenton reaction substrates in porcine thyroid by Stepniak, J, Lewinski, A, Karbownik-Lewinska, M

“…► Both Fenton reaction substrates (Fe2+, H2O2) are indispensable for thyroid hormone synthesis. ► Evaluation if both substrates are required to induce…”
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Direct contribution of obesity to oxidative damage to macromolecules by Karbownik-Lewinska, Małgorzata, Szosland, Janusz, Kokoszko-Bilska, Agnieszka, Stępniak, Jan, Zasada, Krzysztof, Gesing, Adam, Lewinski, Andrzej

“…Obesity constitutes a common modifiable risk factor for certain non-communicable diseases (NCDs) associated with enhanced oxidative stress. The aim of the…”
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Potassium iodide, but not potassium iodate, as a potential protective agent against oxidative damage to membrane lipids in porcine thyroid by Milczarek, Magdalena, Stępniak, Jan, Lewiński, Andrzej, Karbownik-Lewińska, Małgorzata

“…Fenton reaction (Fe2++H2O2→Fe3++•OH+OH-) is of special significance in the thyroid gland, as both its substrates, i.e. H2O2 and Fe2+, are required for thyroid…”
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High level of oxidized nucleosides in thyroid mitochondrial DNA; damaging effects of Fenton reaction substrates by Karbownik-Lewińska, Małgorzata, Stępniak, Jan, Lewiński, Andrzej

“…The mitochondrial DNA (mtDNA) lies in close proximity to the free radical-producing electron transport chain, thus, it is highly prone to oxidative damage…”
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Melatonin reduces high levels of lipid peroxidation induced by potassium iodate in porcine thyroid by Iwan, Paulina, Stepniak, Jan, Karbownik-Lewinska, Malgorzata

“…Iodine is essential for thyroid hormone synthesis. Under normal iodine supply, calculated physiological iodine concentration in the thyroid is approx. 9 mM…”
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Sexual Dimorphism of NADPH Oxidase/H₂O₂ System in Rat Thyroid Cells; Effect of Exogenous 17β-Estradiol by Stepniak, Jan, Lewinski, Andrzej, Karbownik-Lewinska, Malgorzata

“…It has long been observed that females are more susceptible to thyroid diseases than males. Epidemiological and experimental data show that actions of hormonal…”
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Pro-Oxidative Effect of KIO3 and Protective Effect of Melatonin in the Thyroid—Comparison to Other Tissues by Iwan, Paulina, Stepniak, Jan, Karbownik-Lewinska, Malgorzata

“…Not only iodine deficiency, but also its excess may contribute to thyroid cancer. Potassium iodate (KIO3), which is broadly used in the salt iodization…”
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