Search Results - "Stępkowski, Tomasz M."

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis by Stępkowski, Tomasz M., Kruszewski, Marcin K.

“…Oxidative stress, perturbations in the cellular thiol level and redox balance, affects many cellular functions, including signaling pathways. This, in turn,…”
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The role of natural polyphenols in cell signaling and cytoprotection against cancer development by Lewandowska, Hanna, Kalinowska, Monika, Lewandowski, Włodzimierz, Stępkowski, Tomasz M., Brzóska, Kamil

“…The cytoprotective and anticancer action of dietary in-taken natural polyphenols has for long been attributed only to their direct radical scavenging…”
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Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction by Kim, Minji, Serwa, Remigiusz A., Samluk, Lukasz, Suppanz, Ida, Kodroń, Agata, Stępkowski, Tomasz M., Elancheliyan, Praveenraj, Tsegaye, Biniyam, Oeljeklaus, Silke, Wasilewski, Michal, Warscheid, Bettina, Chacinska, Agnieszka

“…Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an important role in neurodegenerative diseases, however, the…”
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Temporal alterations of the nascent proteome in response to mitochondrial stress by Stępkowski, Tomasz M., Linke, Vanessa, Stadnik, Dorota, Zakrzewski, Maciej, Zawada, Anna E., Serwa, Remigiusz A., Chacinska, Agnieszka

“…Under stress, protein synthesis is attenuated to preserve energy and mitigate challenges to protein homeostasis. Here, we describe, with high temporal…”
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LDL dinitrosyl iron complex acts as an iron donor in mouse macrophages by Lewandowska, Hanna, Stępkowski, Tomasz M., Męczyńska-Wielgosz, Sylwia, Sikorska, Katarzyna, Sadło, Jarosław, Dudek, Jakub, Kruszewski, Marcin

“…[Fe(NO)2] – modified nanoparticles of low-density protein (DNICLDL) can serve as conveyors of iron in the form of stable complexes with ApoB100 protein. As…”
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Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element by Brzóska, Kamil, Stępkowski, Tomasz M., Kruszewski, Marcin

“…Pirin, a product of the PIR gene, is an iron-binding protein acting as a transcriptional coregulator implicated in the regulation of the NF-κB-related…”
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The Impact of Ag Nanoparticles and CdTe Quantum Dots on Expression and Function of Receptors Involved in Amyloid-β Uptake by BV-2 Microglial Cells by Sikorska, Katarzyna, Grądzka, Iwona, Wasyk, Iwona, Brzóska, Kamil, Stępkowski, Tomasz M., Czerwińska, Malwina, Kruszewski, Marcin K.

“…Microglial cells clear the brain of pathogens and harmful debris, including amyloid-β (Aβ) deposits that are formed during Alzheimer’s disease (AD). We studied…”
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mitoLUHMES: An Engineered Neuronal Cell Line for the Analysis of the Motility of Mitochondria by Stępkowski, Tomasz M., Męczyńska-Wielgosz, Sylwia, Kruszewski, Marcin

“…Perturbations in the transport of mitochondria and their quality control in neuronal cells underlie many types of neurological pathologies, whereas systems…”
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Adaptation of HepG2 cells to silver nanoparticles-induced stress is based on the pro-proliferative and anti-apoptotic changes in gene expression by Brzóska, Kamil, Męczyńska-Wielgosz, Sylwia, Stępkowski, Tomasz M, Kruszewski, Marcin

“…Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials due to their antibacterial properties. Owing to the recent boost in the usage of…”
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Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity by Lewandowska, Hanna, Sadło, Jarosław, Męczyńska, Sylwia, Stępkowski, Tomasz M, Wójciuk, Grzegorz, Kruszewski, Marcin

“…Dinitrosyl iron(i) complexes (DNICs), intracellular NO donors, are important factors in nitric oxide-dependent regulation of cellular metabolism and signal…”
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Impact of polymorphism of selected genes on the diagnosis of type 2 diabetes in patients with obstructive sleep apnea by Bielicki, Piotr, Pływaczewski, Robert, Brzóska, Kamil, Kumor, Marta, Barnaś, Małgorzata, Jonczak, Luiza, Stępkowski, Tomasz M, Piechuta, Aleksandra, Chazan, Ryszarda, Śliwiński, Paweł, Kruszewski, Marcin

“…INTRODUCTION Although the coexistence of type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) may be attributed to environmental risk factors…”
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Coordination of iron ions in the form of histidinyl dinitrosyl complexes does not prevent their genotoxicity by Lewandowska, Hanna, Stępkowski, Tomasz M., Sadło, Jarosław, Wójciuk, Grzegorz P., Wójciuk, Karolina E., Rodger, Alison, Kruszewski, Marcin

“…Nicking of the plasmid DNA by HIS-DNIC. Filled box—supercoiled form (CCC); hatched box—open cicrular form (OC); empty box—linear form (L). Formation of…”
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Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice by Brzóska, Kamil, Stępkowski, Tomasz M, Kruszewski, Marcin

“…Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-κB1(p50). Alterations…”
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