Search Results - "Stämpfli, M. R."

Hydroxychloroquine attenuates cigarette smoke induced autophagic signaling in the mouse ovary by Furlong, H.C., Wessels, J.M., Guerra, M.T., Stämpfli, M.R., Foster, W.G.

“…•Cigarette smoke exposure induces increased ovarian granulosa cell autophagy.•Chloroquine attenuates cigarette smoke-induced autophagy in the mouse…”
Get full text

A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke by BOTELHO, F. M, NIKOTA, J. K, SLEEMAN, M. A, BAUER, C, DAVIS, N. H. E, COHEN, E. S, ANDERSON, I. K, COYLE, A. J, KOLBECK, R, HUMBLES, A. A, STÄMPFLI, M. R

“…We investigated the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in a subchronic exposure model of cigarette smoke (CS)-induced…”
Get full text

GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice by Stämpfli, M R, Wiley, R E, Neigh, G S, Gajewska, B U, Lei, X F, Snider, D P, Xing, Z, Jordana, M

“…The purpose of this study was to explore whether repeated exposure to aerosolized ovalbumin (OVA) in the context of local expression of GM-CSF can initiate a…”
Get full text

Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation by Ohkawara, Y, Lei, X F, Stämpfli, M R, Marshall, J S, Xing, Z, Jordana, M

“…Selective accumulation of eosinophils and activated CD4+ cells is now considered a central event in the pathogenesis of asthma, and this process is thought to…”
Get more information

Compartmentalized transgene expression of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) in mouse lung enhances allergic airways inflammation by Lei, X F, Ohkawara, Y, Stämpfli, M R, Gauldie, J, Croitoru, K, Jordana, M, Xing, Z

“…To investigate the role of GM‐CSF in asthmatic airways inflammation, we have targeted GM‐CSF transgene to the airway cells in a mouse model of ovalbumin…”
Get full text

Inhalation of a harmless antigen (ovalbumin) elicits immune activation but divergent immunoglobulin and cytokine activities in mice by Swirski, F. K., Gajewska, B. U., Alvarez, D., Ritz, S. A., Cundall, M. J., Cates, E. C., Coyle, A. J., Gutierrez-Ramos, J.-C., Inman, M. D., Jordana, M., Stämpfli, M. R.

“…Background Exposure to aerosolized harmless antigen such as ovalbumin (OVA) has previously been shown to induce inhalation tolerance, a state characterized by…”
Get full text

Adenoviral infection inhibits allergic airways inflammation in mice by STÄMPFLI, M. R, RITZ, S. A, NEIGH, G. S, SIME, P. J, LEI, X. F, XING, Z, CROITORU, K, JORDANA, M

“…Background Recent epidemiological studies have suggested that exposure to certain viruses and bacteria influences the development of allergy and allergic…”
Get full text

Mechanisms of clearance of nontypeable Haemophilus influenzae from cigarette smoke-exposed mouse lungs by GASCHLER, G. J, ZAVITZ, C. C. J, BAUER, C. M. T, STIIMPFLI, M. R

“…Inflammation is prevalent in all stages of chronic obstructive pulmonary disease, and, furthermore, individuals undergo periods of exacerbation, during which…”
Get full text

Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema by Khan, M. A, Kianpour, S, Stampfli, M. R, Janssen, L. J

“…Thin-slice videomicroscopy was used to examine the kinetics of constriction in small airways in situ. Balb/C mice inhaled elastase (0-20 IU), and were then…”
Get full text

Temporal-Spatial Analysis of the Immune Response in a Murine Model of Ovalbumin-Induced Airways Inflammation by Gajewska, Beata U, Swirski, Filip K, Alvarez, David, Ritz, Stacey A, Goncharova, Susanna, Cundall, Meghan, Snider, Denis P, Coyle, Anthony J, Gutierrez-Ramos, Jose-Carlos, Stampfli, Martin R, Jordana, Manel

“…The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways…”
Get full text

Neuropeptides are potent modulators of human in vitro immunoglobulin E synthesis by Aebischer, I, Stämpfli, M R, Zürcher, A, Miescher, S, Urwyler, A, Frey, B, Luger, T, White, R R, Stadler, B M

“…We determined the effect of adrenocorticotropin hormone (ACTH) on the regulation of IgE synthesis. Depending on the concentration, ACTH enhanced or inhibited…”
Get more information

The lung cytokine microenvironment influences molecular events in the lymph nodes during Th1 and Th2 respiratory mucosal sensitization to antigen in vivo by RITZ, S. A., CUNDALL, M. J., GAJEWSKA, B. U., SWIRSKI, F. K., WILEY, R. E., ALVAREZ, D., COYLE, A. J., STAMPFLI, M. R., JORDANA, M.

“…SUMMARY Originally defined by their patterns of cytokine production, Th1 and Th2 cells have been described more recently to express other genes differentially…”
Get full text

Interaction of human IgE with Fc epsilon RI alpha exposes hidden epitopes on IgE by Nechansky, A, Ruf, C, Pursch, E, Wasserbauer, E, Stämpfli, M R, Pachlopnik, J M, Stadler, B M, Kricek, F

“…Binding of human IgE via the heavy-chain constant region domain 3 (Cepsilon3) to the alpha-chain of its high affinity receptor (FcepsilonRIalpha) is a key…”
Get more information

Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice by Stampfli, Martin R, Cwiartka, Monika, Gajewska, Beata U, Alvarez, David, Ritz, Stacey A, Inman, Mark D, Xing, Zhou, Jordana, Manel

“…The objective of this study was to investigate the effect of airway gene transfer of interleukin (IL)-10, a cytokine with potent anti-inflammatory and…”
Get full text

Antigen interaction and heat inactivation expose new epitopes on human IgE by Pachlopnik, J M, Stämpfli, M R, Rudolf, M P, Aebischer, I, Kricek, F, Miescher, S, Stadler, B M

“…It is well established that heat-denatured IgE is no longer capable of binding to FcepsilonRI. We have found an antibody that interacts with heat-denatured…”
Get more information

Generation of experimental allergic airways inflammation in the absence of draining lymph nodes by Gajewska, B U, Alvarez, D, Vidric, M, Goncharova, S, Stämpfli, M R, Coyle, A J, Gutierrez-Ramos, J C, Jordana, M

“…The objective of this study was to investigate the contribution of secondary lymphoid organs in the generation and maintenance of experimental allergic airway…”
Get full text

Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway by Stampfli, Martin R, Scott Neigh, G, Wiley, Ryan E, Cwiartka, Monika, Ritz, Stacey A, Hitt, Mary M, Xing, Zhou, Jordana, Manel

“…Expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in the airway allows allergic sensitization to ovalbumin (OVA) in an experimental…”
Get full text

Expression of the Th1 chemokine IFN-gamma-inducible protein 10 in the airway alters mucosal allergic sensitization in mice by Wiley, R, Palmer, K, Gajewska, B, Stämpfli, M, Alvarez, D, Coyle, A, Gutierrez-Ramos, J, Jordana, M

“…Although the preliminary characterization of chemokines and their receptors has been prolific, comparatively little is known about the role of chemokines in…”
Get full text

Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood by Al-Garawi, A, Fattouh, R, Botelho, F, Walker, T D, Goncharova, S, Moore, C-L, Mori, M, Erjefalt, J S, Chu, D K, Humbles, A A, Kolbeck, R, Stampfli, M R, O'Byrne, P M, Coyle, A J, Jordana, M

“…The origins of allergic asthma, particularly in infancy, remain obscure. Respiratory viral infections and allergen sensitization in early life have been…”
Get full text

Domain-specific anti-IgE antibodies interfere with IgE binding to Fc epsilon RII by Miescher, S, Vogel, M, Stämpfli, M R, Wasserbauer, E, Kricek, F, Vorburger, S, Stadler, B M

“…Human anti-IgE autoantibodies have been identified and implicated in the regulation of IgE-mediated reactions and IgE synthesis. In order to study the…”
Get more information