Search Results - "Srour, Nivine"

Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes by Lambert, Jean-Marie, Ashi, Mohamad Omar, Srour, Nivine, Delpy, Laurent, Saulière, Jérôme

“…The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell as they encode potentially deleterious truncated proteins that can…”
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The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells by Lambert, Jean-Marie, Srour, Nivine, Delpy, Laurent

“…The random V(D)J recombination process ensures the diversity of the primary immunoglobulin (Ig) repertoire. In two thirds of cases, imprecise recombination…”
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Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching by Marchalot, Anne, Ashi, Mohamad Omar, Lambert, Jean-Marie, Carrion, Claire, Lecardeur, Sandrine, Srour, Nivine, Delpy, Laurent, Le Pennec, Soazig

“…Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin…”
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The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells by Lambert, Jean-Marie, Srour, Nivine, Delpy, Laurent

“…The random V(D)J recombination process ensures the diversity of the primary immunoglobulin (Ig) repertoire. In two thirds of cases, imprecise recombination…”
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Putting introns on retainer by Srour, Nivine, Richard, Stéphane

“…Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a…”
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M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge by Srour, Nivine, Mersaoui, Sofiane Y., Richard, Stéphane

“…In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on…”
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PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade by Srour, Nivine, Villarreal, Oscar D., Hardikar, Swanand, Yu, Zhenbao, Preston, Samuel, Miller, Wilson H., Szewczyk, Magdelena M., Barsyte-Lovejoy, Dalia, Xu, Han, Chen, Taiping, del Rincón, Sonia V., Richard, Stéphane

“…Despite the success of immune checkpoint inhibitor (ICI) therapy for cancer, resistance and relapse are frequent. Combination therapies are expected to enhance…”
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The Influence of Arginine Methylation in Immunity and Inflammation by Srour, Nivine, Khan, Sarah, Richard, Stephane

“…Exploration in the field of epigenetics has revealed that protein arginine methyltransferases (PRMTs) contribute to disease, and this has given way to the…”
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A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production by Srour, Nivine, Chemin, Guillaume, Tinguely, Aurélien, Ashi, Mohamad Omar, Oruc, Zéliha, Péron, Sophie, Sirac, Christophe, Cogné, Michel, Delpy, Laurent

“…Aberrantly rearranged immunoglobulin (Ig) alleles are frequent. They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay…”
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A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy by Bonaud, Amélie, Bender, Sébastien, Touchard, Guy, Lacombe, Corinne, Srour, Nivine, Delpy, Laurent, Oblet, Christelle, Druilhe, Anne, Quellard, Nathalie, Javaugue, Vincent, Cogné, Michel, Bridoux, Frank, Sirac, Christophe

“…Randall-type heavy chain deposition disease (HCDD) is a rare disorder characterized by glomerular and peritubular amorphous deposits of a truncated monoclonal…”
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Physiological and druggable skipping of immunoglobulin variable exons in plasma cells by Ashi, Mohamad Omar, Srour, Nivine, Lambert, Jean-Marie, Marchalot, Anne, Martin, Ophélie, Le Noir, Sandrine, Pinaud, Eric, Ayala, Maria Victoria, Sirac, Christophe, Saulière, Jérôme, Moreaux, Jérôme, Cogné, Michel, Delpy, Laurent

“…The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that…”
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