Search Results - "Srour, Aladdin"

Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors by Srour, Aladdin M., Ahmed, Nesreen S., Abd El-Karim, Somaia S., Anwar, Manal M., El-Hallouty, Salwa M.

“…New functionalized thiazol-benzimidazole derivatives were designed, synthesized and evaluated for their in vitro EGFR inhibiting activities. In vitro…”
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New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2 by Seliem, Israa A., Panda, Siva S., Girgis, Adel S., Moatasim, Yassmin, Kandeil, Ahmed, Mostafa, Ahmed, Ali, Mohamed A., Nossier, Eman S., Rasslan, Fatma, Srour, Aladdin M., Sakhuja, Rajeev, Ibrahim, Tarek S., Abdel-samii, Zakaria K.M., Al-Mahmoudy, Amany M.M.

“…A series of quinolone-triazole conjugates synthesized as potential antiviral agents for SARS-CoV2. Some of the conjugates are more potent than the standards…”
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Barbiturate-sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies by Kassem, Asmaa F, Omar, Mohamed A, Temirak, Ahmed, El-Shiekh, Riham A, Srour, Aladdin M

“…Design and synthesis of a series of 5-benzylidene(thio)barbiturates . Evaluation of the inhibitory activity of the new chemical entities on…”
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Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties by Fawazy, Nehmedo G., Panda, Siva S., Mostafa, Ahmed, Kariuki, Benson M., Bekheit, Mohamed S., Moatasim, Yassmin, Kutkat, Omnia, Fayad, Walid, El-Manawaty, May A., Soliman, Ahmed A. F., El-Shiekh, Riham A., Srour, Aladdin M., Barghash, Reham F., Girgis, Adel S.

“…A series of 1″-(alkylsulfonyl)-dispiro[indoline-3,2′-pyrrolidine-3′,3″-piperidine]-2,4″-diones 6a‒o has been synthesized through regioselective multi-component…”
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Synthesis and molecular docking simulation of new benzimidazole–thiazole hybrids as cholinesterase inhibitors by Dawood, Dina H., Srour, Aladdin M., Omar, Mohamed A., Farghaly, Thoraya A., El‐Shiekh, Riham A.

“…Dementia is a cognitive disturbance that is generally correlated with central nervous system diseases, especially Alzheimer's disease. The limited number of…”
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Synthesis and Cytotoxic Properties of New Substituted Glycosides-Indole Conjugates as Apoptosis Inducers in Cancer Cells by Srour, Aladdin M, El-Bayaa, Mohamed N, Omran, Mervat M, Sharaky, Marwa M, El-Sayed, Wael A

“…Glycosyl heterocycles, being as nucleoside analogs with modified glycon and hybrid heterocycle motifs, are of considerable interest, and thus, the targeted…”
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Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties by Srour, Aladdin M., Panda, Siva S., Mostafa, Ahmed, Fayad, Walid, El-Manawaty, May A., A. F. Soliman, Ahmed, Moatasim, Yassmin, El Taweel, Ahmed, Abdelhameed, Mohamed F., Bekheit, Mohamed S., Ali, Mohamed A., Girgis, Adel S.

“…Series of salicylate-curcumin mimics were synthesized of potential antiproliferative (against A431 and HCT116 cell lines) and anti-SARS-CoV-2 properties…”
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Synthesis and 2D-QSAR Study of Active Benzofuran-Based Vasodilators by Khalifa, Nagy M, Srour, Aladdin M, Abd El-Karim, Somaia S, Saleh, Dalia O, Al-Omar, Mohamed A

“…A new series of 2-alkyloxy-pyridine-3-carbonitrile-benzofuran hybrids ( - ) was synthesized. All the new derivatives were examined via the standard technique…”
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Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetylphenyl)carbamoyl]phenyl acetate by Mohamed-Ezzat, Reham A., Kariuki, Benson M., Srour, Aladdin M.

“…2-[(4-Acetylphenyl)carbamoyl]phenyl acetate, C 17 H 15 NO 4 , has been synthesized and structurally characterized. In the structure, N—H...O hydrogen-bonding…”
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Novel Curcumin Inspired Antineoplastic 1-Sulfonyl-4-Piperidones: Design, Synthesis and Molecular Modeling Studies by Fawzy, Nehmedo G, Panda, Siva S, Fayad, Walid, El-Manawaty, May A, Srour, Aladdin M, Girgis, Adel S

“…Curcumin is a well-known example of plant origin exhibiting promising diverse biological properties such as, anti-inflammatory and antitumor as well as poor…”
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Synthesis, human topoisomerase IIα inhibitory properties and molecular modeling studies of anti-proliferative curcumin mimics by Fawzy, Nehmedo G, Panda, Siva S, Fayad, Walid, Shalaby, ElSayed M, Srour, Aladdin M, Girgis, Adel S

“…3,5-Bis(arylidene)- N -substituted-4-oxo-piperidine-1-carboxamides 24-51 were synthesized as curcumin mimics in a facile pathway through reaction of…”
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Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents by Panda, Siva S, Girgis, Adel S, Honkanadavar, Hitesh H, George, Riham F, Srour, Aladdin M

“…A new set of hybrid conjugates derived from 2-(4-isobutylphenyl)propanoic acid (ibuprofen) is synthesized to overcome the drawbacks of the current…”
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New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents by Dawood, Dina H, Srour, Aladdin M, Saleh, Dalia O, Huff, Kelley J, Greco, Francesca, Osborn, Helen M. I

“…Based on studies that have reported the association between cancer and cardiovascular diseases, new series of pyridine- ( 3a-o ) and/or chromene- ( 4a-e )…”
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Synthesis of Novel Heterocyclic Compounds Containing Thiazolyl-Pyrazoline Moiety from Chalcone Derivatives by Nofal, Zeinab M., Srour, Aladdin M., Mansour, Nahla M., El-Karim, Somaia S. Abd

“…A new set of thiazolyl-pyrazolines 3a-l was prepared by cyclization of carbothioamides 2a-g with phenacyl bromide and/or 4-bromo phenacyl bromide. The new…”
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Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid-isoniazid hybrid conjugates by Panda, Siva S, Girgis, Adel S, Mishra, Bibhuti B, Elagawany, Mohamed, Devarapalli, Venkatasai, Littlefield, William F, Samir, Ahmed, Fayad, Walid, Fawzy, Nehmedo G, Srour, Aladdin M, Bokhtia, Riham M

“…Benzotriazole and microwave mediated syntheses led to a new set of hybrid conjugates of pyrazinoic acid with isoniazid via amino acid linkers in excellent…”
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Rational design, synthesis and molecular modeling studies of novel anti-oncological alkaloids against melanoma by Girgis, Adel S, Panda, Siva S, Srour, Aladdin M, Farag, Hanaa, Ismail, Nasser S M, Elgendy, Mohamed, Abdel-Aziz, Amal K, Katritzky, Alan R

“…3D-pharmacophore and 2D-QSAR modeling studies describe the anti-oncological properties of spiro-alkaloids. The…”
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Synthesis and 2D-QSAR study of dispiropyrrolodinyl-oxindole based alkaloids as cholinesterase inhibitors by Srour, Aladdin M., Dawood, Dina H., Khalil, Mohammed N.A., Nofal, Zienab M.

“…[Display omitted] •We designed and synthesized some new dispiropyrrolodinyl-oxindole -based alkaloids.•We evaluated the newly synthesized analogues as…”
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Rational design, synthesis and 2D-QSAR study of novel vasorelaxant active benzofuran-pyridine hybrids by Srour, Aladdin M., Abd El-Karim, Somaia S., Saleh, Dalia O., El-Eraky, Wafaa I., Nofal, Zeinab M.

“…Some novel bezofuran-pyridinecarbonitrile hybrids as vasorelaxant active agents. [Display omitted] Reaction of 3-aryl-1-(benzofuran-2-yl)-2-propen-1-ones 3a–c…”
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Rational design, synthesis and QSAR study of vasorelaxant active 3-pyridinecarbonitriles incorporating 1H-benzimidazol-2-yl function by Nofal, Zeinab M., Srour, Aladdin M., El-Eraky, Wafaa I., Saleh, Dalia O., Girgis, Adel S.

“…A variety of 2-alkoxy-4-aryl-6-(1H-benzimidazol-2-yl)-3-pyridinecarbonitriles 4a–r were prepared via either regioselective reaction of…”
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Microwave assisted synthesis and QSAR study of novel NSAID acetaminophen conjugates with amino acid linkers by Tiwari, Anand D, Panda, Siva S, Girgis, Adel S, Sahu, Sandhyamayee, George, Riham F, Srour, Aladdin M, La Starza, Brian, Asiri, Abdullah M, Hall, C Dennis, Katritzky, Alan R

“…Novel, non-steroidal anti-inflammatory drug (NSAID), acetaminophen conjugates 6a–l with amino acid linkers were synthesized utilizing benzotriazole chemistry…”
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