Search Results - "Sroor, Farid"

Novel 5-Fluorouracil analogues versus perfluorophenyl ureas as potent anti-breast cancer agents: Design, robust synthesis, in vitro, molecular docking, pharmacokinetics ADMET analysis and dynamic simulations by Sroor, Farid M., El-Sayed, Ahmed F., Mahmoud, Khaled

“…[Display omitted] •5-Fluorouracil-based analogues of 5-arylurea uracil derivatives (AUFU01-03) and aryl-urea derivatives bearing perfluorophenyl (AUPF01-03)…”
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Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer by Tantawy, Mohamed A, Sroor, Farid M, Mohamed, Magda F, El-Naggar, Mostafa E, Saleh, Fatma M, Hassaneen, Hamdi M, Abdelhamid, Ismail A

“…Chalcones are naturally occurring compounds found in various plant species which are widely used for the traditional popular treatments. Chalcones are…”
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Impact of trifluoromethyl and sulfonyl groups on the biological activity of novel aryl-urea derivatives: synthesis, in-vitro, in-silico and SAR studies by Sroor, Farid M., Mahrous, Karima F., El-Kader, Heba A. M. Abd, Othman, Abdelmageed M., Ibrahim, Nada S.

“…We designed and prepared a novel series of urea derivatives with/without sulfonyl group in their structures to investigate the impact of the sulfonyl group on…”
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Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship by Elsayed, Mohamed A., Elsayed, Alshaimaa M., Sroor, Farid M.

“…The rate of microbial resistance has continued to rise significantly as the availability of new antibiotics has declined. A new series of pyridine and…”
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Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents by Sroor, Farid M., Aboelenin, Mohamad M., Mahrous, Karima F., Mahmoud, Khaled, Elwahy, Ahmed H. M., Abdelhamid, Ismail A.

“…Ethyl 2‐acrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carboxylate as well as its corresponding bis‐derivatives, 5–10, with aliphatic linkers were…”
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Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights by Sroor, Farid M., Soliman, Ahmed A. F., Youssef, Elham Mohamed, Abdelraof, Mohamed, El-Sayed, Ahmed F.

“…A very practical method for the synthesis of unsymmetrical carbamide derivatives in good to excellent yield was presented, without the need for any catalyst…”
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Design, synthesis, structure elucidation, antimicrobial, molecular docking, and SAR studies of novel urea derivatives bearing tricyclic aromatic hydrocarbon rings by Sroor, Farid M., El‐Sayed, Ahmed F., Abdelraof, Mohamed

“…The targeted compounds were prepared using both (9H‐fluoren‐9‐ylidene)hydrazine (1) and 10H‐phenothiazine (2) as starting materials. The treatment of 1 or 2…”
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Synthesis, antimicrobial, anti-cancer and in silico studies of new urea derivatives by Sroor, Farid M., Othman, Abdelmageed M., Tantawy, Mohamed A., Mahrous, Karima F., El-Naggar, Mostafa E.

“…Series of alkyl- and aryl- urea derivatives 5–17 were prepared and evaluated in vitro as antimicrobial and anticancer agents. The reaction of isocyanates with…”
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Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies by Yasser, Norhan, Sroor, Farid M, El-Shorbagy, Haidan M, Eissa, Shaymaa M, Hassaneen, Hamdi M, Abdelhamid, Ismail A

“…A unique series of pyrazolyl-chalcone derivatives was synthesized the method of Claisen-Schmidt condensation. The desired chalcone derivatives 7a-d and 9a-f…”
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Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies by Sroor, Farid M., Othman, Abdelmageed M., Aboelenin, Mohamad M., Mahrous, Karima F.

“…The drug resistance became the major challenge in the antimicrobial and anticancer drugs therapy. Therefore, there is an urgent need to looking for new types…”
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Design, synthesis and in‐vitro evaluation of new furan‐substituted thiadiazolyl hydrazone derivatives as promising antimicrobial agents by Helmy, Mirna T., Sroor, Farid M., Othman, Abdelmageed M., Hassaneen, Hamdi M., Saleh, Fatma M., Teleb, Mohamed A. Mohamed

“…Seventeen new furan‐substituted thiadiazolyl hydrazone derivatives bearing 4‐nitrophenyl moiety were designed, synthesized and tested for their in vitro…”
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Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR by Kamel, Monica G, Sroor, Farid M, Hanafy, Mahmoud Kh, Mahrous, Karima F, Hassaneen, Hamdi M

“…Less than 5% of pancreatic cancer patients survive for more than five years after diagnosis. Therefore, there is an urgent need for novel therapeutic drugs to…”
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Synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine-3-carboxamide as antimicrobial agents by Hassan, Ashraf S., Masoud, Doaa M., Sroor, Farid M., Askar, Ahmed A.

“…Exploring novel classes of antimicrobial therapeutics is an excellent approach to face the challenge of microbial resistance. In this context, a novel series…”
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Synthesis and Structural Characterization of Divalent Transition Metal Alkynylamidinate Complexes by Wang, Sida, Liebing, Phil, Feneberg, Martin, Sroor, Farid M., Engelhardt, Felix, Hilfert, Liane, Busse, Sabine, Kluth, Elias, Goldhahn, Rüdiger, Edelmann, Frank T.

“…A series of new alkynylamidinate complexes of selected first and second row transition metals has been synthesized and fully characterized. Treatment of MCl2…”
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Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies by Helmy, Mirna T., Sroor, Farid M., Mahrous, Karima F., Mahmoud, Khaled, Hassaneen, Hamdi M., Saleh, Fatma M., Abdelhamid, Ismail A., Mohamed Teleb, Mohamed A.

“…Twelve novel chalcone derivatives were prepared using the Claisen–Schmidt condensation reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole…”
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Structure-based design of novel pyrazolyl–chalcones as anti-cancer and antimicrobial agents: synthesis and in vitro studies by Kamel, Monica G., Sroor, Farid M., Othman, Abdelmageed M., Mahrous, Karima F., Saleh, Fatma M., Hassaneen, Hamdi M., Abdallah, Tayseer A., Abdelhamid, Ismail A., Teleb, Mohamed A. Mohamed

“…A new series of pyrazolyl–chalcone derivatives was prepared in moderate yields via Claisen–Schmidt condensation reaction of 4-acetylpyrazole derivatives with…”
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Synthesis and biological evaluation of new 1,3,4-thiadiazole derivatives as potent antimicrobial agents by Kamel, Monica G., Sroor, Farid M., Othman, Abdelmageed M., Hassaneen, Hamdi M., Abdallah, Tayseer A., Saleh, Fatma M., Teleb, Mohamed A. Mohamed

“…A series of 1,3,4-thiadiazole derivatives were designed and synthesized using N -(4-nitrophenyl)acetohydrazonoyl bromide and…”
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Synthesis and molecular docking studies of some new thiosemicarbazone derivatives as HCV polymeraseinhibitors by Sroor, Farid M., Khatab, Tamer K., Basyouni, Wahid M., El-Bayouki, Khairy A. M.

“…Series of new thiosemicarbazones was prepared and molecular studied as inhibitors of HCV 4WTG polymerase. Thus, the thiosemicarbazone derivatives (3a-k) were…”
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Synthesis and Evaluation of New 3,4-Dihydropyrimidin-2-(1H)-Ones and -Thiones as Anti-Cancer Agents: In Vitro, Molecular Docking and SAR Studies by Abdelazeem, Nagwa M., Sroor, Farid M., Basyouni, Wahid M., Adel, Islam, Tantawy, Mohamed A.

“…Using Silica Sulfuric Acid (SSA) as an eco-friendly, readily available, and reusable catalyst, herein we were prepared a new series of…”
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In silico and in vitro studies of novel cyanoacrylamides incorporating pyrazole moiety against breast and prostate carcinomas by Sroor, Farid M., Mahrous, Karima F., Shafey, Heba I., Eid, Nedal R., Abdelhamid, Ismail A., Ibrahim, Nada S.

“…We report novel cyanoacrylamide derivatives bearing the pyrazole moiety. The molecular structures of the prepared cyanoacrylamides were confirmed by the…”
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