Search Results - "Sriwastva, Mukesh K."

High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance by Kumar, Anil, Sundaram, Kumaran, Mu, Jingyao, Dryden, Gerald W., Sriwastva, Mukesh K., Lei, Chao, Zhang, Lifeng, Qiu, Xiaolan, Xu, Fangyi, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L., Bohler, Henry C. L., Wang, Baomei, Zhang, Shuangqin, Qin, Chao, Xu, Ziying, Han, Xianlin, McClain, Craig J., Teng, Yun, Zhang, Huang-Ge

“…High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance is largely unknown. Here, we show that lean mice become insulin…”
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Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis by Sundaram, Kumaran, Miller, Daniel P., Kumar, Anil, Teng, Yun, Sayed, Mohammed, Mu, Jingyao, Lei, Chao, Sriwastva, Mukesh K., Zhang, Lifeng, Yan, Jun, Merchant, Michael L., He, Liqing, Fang, Yuan, Zhang, Shuangqin, Zhang, Xiang, Park, Juw W., Lamont, Richard J., Zhang, Huang-Ge

“…Plant exosomes protect plants against infection; however, whether edible plant exosomes can protect mammalian hosts against infection is not known. In this…”
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Lemon exosome-like nanoparticles enhance stress survival of gut bacteria by RNase P-mediated specific tRNA decay by Lei, Chao, Teng, Yun, He, Liqing, Sayed, Mohammed, Mu, Jingyao, Xu, Fangyi, Zhang, Xiangcheng, Kumar, Anil, Sundaram, Kumaran, Sriwastva, Mukesh K., Zhang, Lifeng, Chen, Shao-yu, Feng, Wenke, Zhang, Shuangqin, Yan, Jun, Park, Juw Won, Merchant, Michael L., Zhang, Xiang, Zhang, Huang-Ge

“…Diet and bile play critical roles in shaping gut microbiota, but the molecular mechanism underlying interplay with intestinal microbiota is unclear. Here, we…”
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An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth by Sriwastva, Mukesh K., Teng, Yun, Mu, Jingyao, Xu, Fangyi, Kumar, Anil, Sundaram, Kumaran, Malhotra, Rajiv Kumar, Xu, Qingbo, Hood, Joshua L., Zhang, Lifeng, Yan, Jun, Merchant, Michael L., Park, Juw Won, Dryden, Gerald W., Egilmez, Nejat K., Zhang, Huang‐Ge

“…Extracellular vesicles (EVs) contain more than 100 proteins. Whether there are EVs proteins that act as an ‘organiser’ of protein networks to generate a new or…”
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Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota by Teng, Yun, Ren, Yi, Sayed, Mohammed, Hu, Xin, Lei, Chao, Kumar, Anil, Hutchins, Elizabeth, Mu, Jingyao, Deng, Zhongbin, Luo, Chao, Sundaram, Kumaran, Sriwastva, Mukesh K., Zhang, Lifeng, Hsieh, Michael, Reiman, Rebecca, Haribabu, Bodduluri, Yan, Jun, Jala, Venkatakrishna Rao, Miller, Donald M., Van Keuren-Jensen, Kendall, Merchant, Michael L., McClain, Craig J., Park, Juw Won, Egilmez, Nejat K., Zhang, Huang-Ge

“…The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate…”
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Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis by Sundaram, Kumaran, Miller, Daniel P., Kumar, Anil, Teng, Yun, Sayed, Mohammed, Mu, Jingyao, Lei, Chao, Sriwastva, Mukesh K., Zhang, Lifeng, Yan, Jun, Merchant, Michael L., He, Liqing, Fang, Yuan, Zhang, Shuangqin, Zhang, Xiang, Park, Juw W., Lamont, Richard J., Zhang, Huang-Ge

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Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway by Sriwastva, Mukesh K, Deng, Zhong‐Bin, Wang, Bomei, Teng, Yun, Kumar, Anil, Sundaram, Kumaran, Mu, Jingyao, Lei, Chao, Dryden, Gerald W, Xu, Fangyi, Zhang, Lifeng, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Egilmez, Nejat K, Zhang, Huang‐Ge

“…Bark protects the tree against environmental insults. Here, we analyzed whether this defensive strategy could be utilized to broadly enhance protection against…”
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Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death by Teng, Yun, Mu, Jingyao, Xu, Fangyi, Zhang, Xiangcheng, Sriwastva, Mukesh K., Liu, Qiaohong M., Li, Xiaohong, Lei, Chao, Sundaram, Kumaran, Hu, Xin, Zhang, Lifeng, Park, Juw Won, Hwang, Jae Yeon, Rouchka, Eric C., Zhang, Xiang, Yan, Jun, Merchant, Michael L., Zhang, Huang-Ge

“…The intestinal microbiome releases a plethora of small molecules. Here, we show that the Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice…”
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Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin‐1 Complex Into Microglial Exosomes by Xu, Fangyi, Mu, Jingyao, Teng, Yun, Zhang, Xiangcheng, Sundaram, Kumaran, Sriwastva, Mukesh K., Kumar, Anil, Lei, Chao, Zhang, Lifeng, Liu, Qiaohong M., Yan, Jun, McClain, Craig J., Merchant, Michael L., Zhang, Huang‐Ge

“…Microglia modulate pro‐inflammatory and neurotoxic activities. Edible plant‐derived factors improve brain function. Current knowledge of the molecular…”
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Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis by Sundaram, Kumaran, Mu, Jingyao, Kumar, Anil, Behera, Jyotirmaya, Lei, Chao, Sriwastva, Mukesh K, Xu, Fangyi, Dryden, Gerald W, Zhang, Lifeng, Chen, ShaoYu, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Tyagi, Neetu, Teng, Yun, Zhang, Huang-Ge

“…Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity and metabolic co-morbidities is challenging. Obesity induced…”
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Lactobacillus rhamnosus GG alleviates colitis caused by chemotherapy via biofilm formation by Qiu, Xiaolan, Han, Xuedong, Zhang, Xiangcheng, Teng, Lucy A, Sriwastva, Mukesh K, Zhen, Linlin, Li, Zhi, Liu, Minmin, Ren, Yi, Wang, Shui

“…Background and Aim Severe colitis is a common side effect of chemotherapy in cancer patients. In this study, we attempted to enhance the viability of…”
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miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase ( tnaA ) gene by Kumar, Anil, Ren, Yi, Sundaram, Kumaran, Mu, Jingyao, Sriwastva, Mukesh K, Dryden, Gerald W, Lei, Chao, Zhang, Lifeng, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Teng, Yun, Zhang, Huang-Ge

“…Diet manipulation is the basis for prevention of obesity and diabetes. The molecular mechanisms that mediate the diet-based prevention of insulin resistance…”
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Outer Membrane Vesicles Released from Garlic Exosome‐like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut‐Brain Axis by Sundaram, Kumaran, Teng, Yun, Mu, Jingyao, Xu, Qingbo, Xu, Fangyi, Sriwastva, Mukesh K., Zhang, Lifeng, Park, Juw Won, Zhang, Xiang, Yan, Jun, Zhang, Shuang Qin, Merchant, Michael L., Chen, Shao‐yu, McClain, Craig J, Dryden, Gerald W, Zhang, Huang‐Ge

“…Gut microbiota function has numerous effects on humans and the diet humans consume has emerged as a pivotal determinant of gut microbiota function. Here, a new…”
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Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways by Wang, Qi-Long, Zhuang, XiaoYing, Sriwastva, Mukesh K, Mu, Jingyao, Teng, Yun, Deng, Zhongbin, Zhang, Lifeng, Sundaram, Kumaran, Kumar, Anil, Miller, Donald, Yan, Jun, Zhang, Huang-Ge

“…Tumor-specific delivery of therapeutics is challenging. One of the major hurdles for successfully delivering targeted agents by nanovectors is the filtering…”
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Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance by Kumar, Anil, Sundaram, Kumaran, Teng, Yun, Mu, Jingyao, Sriwastva, Mukesh K, Zhang, Lifeng, Hood, Joshua L, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Zhang, Huang-Ge

“…The obesity epidemic has expanded globally, due in large part to the increased consumption of high-fat diets (HFD), and has increased the risk of major chronic…”
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Lemon Exosome-like Nanoparticles-Manipulated Probiotics Protect Mice from C. diff Infection by Lei, Chao, Mu, Jingyao, Teng, Yun, He, Liqing, Xu, Fangyi, Zhang, Xiangcheng, Sundaram, Kumaran, Kumar, Anil, Sriwastva, Mukesh K., Lawrenz, Matthew B., Zhang, Lifeng, Yan, Jun, Feng, Wenke, McClain, Craig J., Zhang, Xiang, Zhang, Huang-Ge

“…Clostridioides difficile (C. diff) is the leading cause of antibiotic-associated colitis. Here, we report that lemon exosome-like nanoparticles (LELNs)…”
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Rab1A-Mediated Exosomal Sorting of miR-200c Enhances Breast Cancer Lung Metastasis by Liu, Yuting, Tang, Jie, Qiu, Xiaolan, Teng, Lucy A, Sriwastva, Mukesh K, Han, Xuedong, Li, Zhi, Liu, Minmin, Liu, Shuangyue, Da, Dongzhu, Zhen, Linlin, Ren, Yi

“…Recent therapeutic approaches have improved survival rate for women with breast cancer, but the survival rate for metastatic breast cancer is still low…”
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Tu1184 INTESTINAL EPITHELIAL NEUTRAL CERAMIDASE DEFICIENCY CONFERS PROTECTION AGAINST CHEMICAL COLITIS IN MICE by Xu, Zhishan, Lei, Chao, Sun, Rui, Sriwastva, Mukesh K, Tan, Yi, Deng, Zhongbin

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Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12 by Teng, Yun, Xu, Fangyi, Zhang, Xiangcheng, Mu, Jingyao, Sayed, Mohammed, Hu, Xin, Lei, Chao, Sriwastva, Mukesh, Kumar, Anil, Sundaram, Kumaran, Zhang, Lifeng, Park, Juw Won, Chen, Shao-yu, Zhang, Shuangqin, Yan, Jun, Merchant, Michael L., Zhang, Xiang, McClain, Craig J., Wolfe, Jennifer K., Adcock, Robert S., Chung, Donghoon, Palmer, Kenneth E., Zhang, Huang-Ge

“…Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we show that mice develop inflamed lung tissue after being administered…”
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Lemon Exosome-like Nanoparticles-Manipulated Probiotics Protect Mice from C. d iff Infection by Lei, Chao, Mu, Jingyao, Teng, Yun, He, Liqing, Xu, Fangyi, Zhang, Xiangcheng, Sundaram, Kumaran, Kumar, Anil, Sriwastva, Mukesh K, Lawrenz, Matthew B, Zhang, Lifeng, Yan, Jun, Feng, Wenke, McClain, Craig J, Zhang, Xiang, Zhang, Huang-Ge

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