Search Results - "Srivastava, Pramod K."

Neoepitopes of Cancers: Looking Back, Looking Ahead by Srivastava, Pramod K

“…The search for specificity in cancers has been a holy grail in cancer immunology. Cancer geneticists have long known that cancers harbor transforming and other…”
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Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity by Duan, Fei, Duitama, Jorge, Al Seesi, Sahar, Ayres, Cory M, Corcelli, Steven A, Pawashe, Arpita P, Blanchard, Tatiana, McMahon, David, Sidney, John, Sette, Alessandro, Baker, Brian M, Mandoiu, Ion I, Srivastava, Pramod K

“…The mutational repertoire of cancers creates the neoepitopes that make cancers immunogenic. Here, we introduce two novel tools that identify, with relatively…”
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Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages by Yang, Yi, Liu, Bei, Dai, Jie, Srivastava, Pramod K., Zammit, David J., Lefrançois, Leo, Li, Zihai

“…gp96 is an endoplasmic reticulum chaperone for cell-surface Toll-like receptors (TLRs). Little is known about its roles in chaperoning other TLRs or in the…”
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Phase III Comparison of Vitespen, an Autologous Tumor-Derived Heat Shock Protein gp96 Peptide Complex Vaccine, With Physician's Choice of Treatment for Stage IV Melanoma: The C-100-21 Study Group by TESTORI, Alessandro, RICHARDS, Jon, YUH, Lianng, GUPTA, Renu, SRIVASTAVA, Pramod K, WHITMAN, Eric, MANN, G. Bruce, LUTZKY, Jose, CAMACHO, Luis, PARMIANI, Giorgio, TOSTI, Giulio, KIRKWOOD, John M, HOOS, Axel

“…To assess the antitumor activity of vitespen (autologous, tumor- derived heat shock protein gp96 peptide complexes) by determining whether patients with stage…”
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GeNeo: A Bioinformatics Toolbox for Genomics-Guided Neoepitope Prediction by Al Seesi, Sahar, Al-Okaily, Anas, Shcheglova, Tatiana V, Sherafat, Elham, Alqahtani, Fahad H, Hagymasi, Adam T, Kaur, Anupinder, Srivastava, Pramod K, Măndoiu, Ion I

“…High-throughput DNA and RNA sequencing are revolutionizing precision oncology, enabling personalized therapies such as cancer vaccines designed to target…”
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Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes by Si, Youhui, Wang, Yihan, Tian, Qiaomu, Wang, Qiang, Pollard, Jared M., Srivastava, Pramod K., Esser-Kahn, Aaron P., Collier, Joel H., Sperling, Anne I., Chong, Anita S.

“…The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence that intranasal administration of peptide…”
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Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope by Ebrahimi-Nik, Hakimeh, Moussa, Marmar, Englander, Ryan P., Singhaviranon, Summit, Michaux, Justine, Pak, HuiSong, Miyadera, Hiroko, Corwin, William L., Keller, Grant L. J., Hagymasi, Adam T., Shcheglova, Tatiana V., Coukos, George, Baker, Brian M., Mandoiu, Ion I., Bassani-Sternberg, Michal, Srivastava, Pramod K.

“…High-affinity MHC I-peptide interactions are considered essential for immunogenicity. However, some neo-epitopes with low affinity for MHC I have been reported…”
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Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation by Callahan, Margaret K, Garg, Manish, Srivastava, Pramod K

“…CD8⁺ T cells recognize peptide fragments of endogenously synthesized antigens of cancers or viruses, presented by MHC I molecules. Such antigen presentation…”
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Cancer neoepitopes viewed through negative selection and peripheral tolerance: a new path to cancer vaccines by Srivastava, Pramod K

“…A proportion of somatic mutations in tumors create neoepitopes that can prime T cell responses that target the MHC I-neoepitope complexes on tumor cells,…”
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Area under the curve as a tool to measure kinetics of tumor growth in experimental animals by Duan, Fei, Simeone, Shauna, Wu, Rong, Grady, James, Mandoiu, Ion, Srivastava, Pramod K.

“…Measurement of tumor diameters or tumor volumes has been traditionally used to quantitate and compare tumor growth curves in mice and rats. Here, we describe…”
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Mass spectrometry driven exploration reveals nuances of neoepitope-driven tumor rejection by Ebrahimi-Nik, Hakimeh, Michaux, Justine, Corwin, William L, Keller, Grant Lj, Shcheglova, Tatiana, Pak, HuiSong, Coukos, George, Baker, Brian M, Mandoiu, Ion I, Bassani-Sternberg, Michal, Srivastava, Pramod K

“…Neoepitopes are the only truly tumor-specific antigens. Although potential neoepitopes can be readily identified using genomics, the neoepitopes that mediate…”
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Essential Role of CD91 in Re-Presentation of gp96-Chaperoned Peptides by Binder, Robert J., Srivastava, Pramod K., Unanue, Emil R.

“…Heat shock proteins (HSPs) such as gp96 are released from cells as a result of necrotic cell death. The ability of endogenous HSP-peptide complexes to elicit…”
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CD91: a receptor for heat shock protein gp96 by Srivastava, Pramod K, Han, David K, Binder, Robert J

“…Antigen presenting cells (APCs) can take up exogenous antigenic peptides chaperoned by heat shock protein gp96 and re-present them through the endogenous…”
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Immunotherapy for human cancer using heat shock protein-peptide complexes by Srivastava, Pramod K

“…Heat shock proteins (HSPs) are primordial and abundant molecules expressed in all cells. Publications starting in 1984 have shown that immunization of mice,…”
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Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs by Panjwani, Naveed N, Popova, Lana, Srivastava, Pramod K

“…NO is a cytotoxic and immunomodulatory cytokine produced by macrophages and dendritic cells. We show that stimulation of murine and human macrophages with the…”
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Vaccination with Autologous Tumor-derived Heat-Shock Protein Gp96 after Liver Resection for Metastatic Colorectal Cancer by MAZZAFERRO, Vincenzo, COPPA, Jorgelina, CAMERINI, Roberto, CORSI, Marco, LEWIS, Jonathan J, SRIVASTAVA, Pramod K, PARMIANI, Giorgio, CARRABBA, Matteo G, RIVOLTINI, Licia, SCHIAVO, Marcello, REGALIA, Enrico, MARIANI, Luigi, CAMERINI, Tiziana, MARCHIANO, Alfonso, ANDREOLA, Salvatore

“…Purpose: Heat shock proteins (HSP) from tumor cells contain the gp96 polypeptide associated with cancer-specific antigenic peptides. Mice that are immunized…”
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Vaccines against advanced melanoma by Blanchard, Tatiana, BS, Srivastava, Pramod K., PhD, MD, Duan, Fei, PhD

“…Abstract Research shows that cancers are recognized by the immune system but that the immune recognition of tumors does not uniformly result in tumor rejection…”
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A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides by Suto, Ryuichiro, Srivastava, Pramod K.

“…Endogenously synthesized antigenic determinants are generally presented on major histocompatibility complex (MHC) class I molecules, whereas exogenous…”
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Endocannabinoid system acts as a regulator of immune homeostasis in the gut by Acharya, Nandini, Penukonda, Sasi, Shcheglova, Tatiana, Hagymasi, Adam T., Basu, Sreyashi, Srivastava, Pramod K.

“…Endogenous cannabinoids (endocannabinoids) are small molecules biosynthesized from membrane glycerophospholipid. Anandamide (AEA) is an endogenous intestinal…”
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Dendritic cells sequester antigenic epitopes for prolonged periods in the absence of antigen-encoding genetic information by Li, Changying, Buckwalter, Matthew R, Basu, Sreyashi, Garg, Manish, Chang, Jiwu, Srivastava, Pramod K

“…Studies with a number of viral systems have shown, on the basis of the ability of a host to prime naïve T cells, that viral antigens persist in the infected…”
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