Search Results - "Sriram, Dharmarajan"

Inhibition of protein kinase R protects against palmitic acid–induced inflammation, oxidative stress, and apoptosis through the JNK/NF‐kB/NLRP3 pathway in cultured H9C2 cardiomyocytes by Mangali, Sureshbabu, Bhat, Audesh, Udumula, Mary Priyanka, Dhar, Indu, Sriram, Dharmarajan, Dhar, Arti

“…Background and Purpose Double‐stranded RNA‐dependent protein kinase (PKR) is a critical regulator of apoptosis, oxidative stress, and inflammation under…”
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Ultrasonication-ionic liquid synergy for the synthesis of new potent anti-tuberculosis 1,2,4-triazol-1-yl-pyrazole based spirooxindolopyrrolizidines by Pogaku, Vinay, Krishna, Vagolu Siva, Sriram, Dharmarajan, Rangan, Krishnan, Basavoju, Srinivas

“…[Display omitted] •New potent anti-TB spirooxindolopyrrolizidines were designed & synthesized by green methodology.•High yields of the products in less…”
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Synthesis of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-(thiophen-2-yl)dihydroquinolines as potent inhibitors of Mycobacterium tuberculosis by Marvadi, Sandeep Kumar, Krishna, Vagolu Siva, Sriram, Dharmarajan, Kantevari, Srinivas

“…A series of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-(thiophen-2-yl)dihydroquinolines 7a–p was designed and synthesized from…”
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Betulinic acid and its derivatives: a review on their biological properties by Yogeeswari, Perumal, Sriram, Dharmarajan

“…Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human…”
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Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents by Kumar, Gautam, Siva Krishna, Vagolu, Sriram, Dharmarajan, Jachak, Sanjay M.

“…Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole–coumarin chalcones and pyrazole–quinoline…”
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Synthesis and evaluation of novel substituted 1,2,3-triazolyldihydroquinolines as promising antitubercular agents by Marvadi, Sandeep Kumar, Krishna, Vagolu Siva, Sriram, Dharmarajan, Kantevari, Srinivas

“…[Display omitted] A series of novel substituted 1,2,3-triazolyldihydroquinolines 6a–o was designed and synthesized from 2-acetylthiophene in five-step reaction…”
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Discovery of Antimycobacterial Spiro-piperidin-4-ones: An Atom Economic, Stereoselective Synthesis, and Biological Intervention by Kumar, Raju Ranjith, Perumal, Subbu, Senthilkumar, Palaniappan, Yogeeswari, Perumal, Sriram, Dharmarajan

“…An atom economic and stereoselective synthesis of several spiro-piperidin-4-ones through 1,3-dipolar cycloaddition of azomethine ylides generated in situ from…”
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Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors by Samala, Ganesh, Devi, Parthiban Brindha, Saxena, Shalini, Meda, Nikhila, Yogeeswari, Perumal, Sriram, Dharmarajan

“…Compound 5bc emerged as potent compound active against MTB PS with IC50 of 0.53±0.13μM, MIC of 3.53μM, 2.1log reduction against nutrient starved MTB. It also…”
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Design, Synthesis, and Structure–Activity Correlations of Novel Dibenzo[b,d]furan, Dibenzo[b,d]thiophene, and N-Methylcarbazole Clubbed 1,2,3-Triazoles as Potent Inhibitors of Mycobacterium tuberculosis by Patpi, Santhosh Reddy, Pulipati, Lokesh, Yogeeswari, Perumal, Sriram, Dharmarajan, Jain, Nishant, Sridhar, Balasubramanian, Murthy, Ramalinga, T, Anjana Devi, Kalivendi, Shasi Vardhan, Kantevari, Srinivas

“…A molecular hybridization approach is an emerging structural modification tool to design new molecules with improved pharmacophoric properties. In this study,…”
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Design, development of new synthetic methodology, and biological evaluation of substituted quinolines as new anti-tubercular leads by Tanwar, Babita, Kumar, Asim, Yogeeswari, Perumal, Sriram, Dharmarajan, Chakraborti, Asit K.

“…[Display omitted] Two series of quinoline-based compounds were designed, synthesised and evaluated for anti-tubercular activity against Mycobacterium…”
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Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents by Malwal, Satish R, Sriram, Dharmarajan, Yogeeswari, Perumal, Konkimalla, V. Badireenath, Chakrapani, Harinath

“…Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported…”
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Discovery and evaluation of novel Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors as therapeutic drug leads by Krishna, Vagolu Siva, Zheng, Shan, Rekha, Estharla Madhu, Guddat, Luke W., Sriram, Dharmarajan

“…Tuberculosis (TB) remains a major threat to human health. This due to the fact that current drug treatments are less than optimal and the increasing occurrence…”
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Benzo[d]thiazole-2-carbanilides as new anti-TB chemotypes: Design, synthesis, biological evaluation, and structure-activity relationship by Dhameliya, Tejas M., Tiwari, Rishu, Banerjee, Arkaprabha, Pancholia, Sahaj, Sriram, Dharmarajan, Panda, Dulal, Chakraborti, Asit K.

“…Tuberculosis is the second leading cause of deaths worldwide. The inadequacy of existing drugs to treat TB due to developed resistance and TB-HIV synergism…”
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Identification and development of benzoxazole derivatives as novel bacterial glutamate racemase inhibitors by Malapati, Prasanthi, Krishna, Vagolu Siva, Nallangi, Radhika, Srilakshmi, Rudraraju Reshma, Sriram, Dharmarajan

“…In the present study, we attempted to develop novel class of Mycobacterium tuberculosis (Mtb) inhibitors by exploring the pharmaceutically underexploited…”
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Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis by Khan, Mehak Zahoor, Hunt, Debbie M, Singha, Biplab, Kapoor, Yogita, Singh, Nitesh Kumar, Prasad, D V Sai, Dharmarajan, Sriram, Sowpati, Divya Tej, de Carvalho, Luiz Pedro S, Nandicoori, Vinay Kumar

“…'s ( ) autarkic lifestyle within the host involves rewiring its transcriptional networks to combat host-induced stresses. With the help of RNA sequencing…”
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New N -phenylacetamide-incorporated 1,2,3-triazoles: [Et 3 NH][OAc]-mediated efficient synthesis and biological evaluation by Akolkar, Satish V, Nagargoje, Amol A, Krishna, Vagolu S, Sriram, Dharmarajan, Sangshetti, Jaiprakash N, Damale, Manoj, Shingate, Bapurao B

“…A facile, highly efficient, and greener method for the synthesis of new 1,4-disubstituted-1,2,3-triazoles was conducted using [Et NH][OAc] as a medium by the…”
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Discovery of potent antimycobacterial agents targeting lumazine synthase (RibH) of Mycobacterium tuberculosis by Singh, Monica, Dhanwal, Anannya, Verma, Arpita, Augustin, Linus, Kumari, Niti, Chakraborti, Soumyananda, Agarwal, Nisheeth, Sriram, Dharmarajan, Dey, Ruchi Jain

“…Tuberculosis (TB) continues to be a global health crisis, necessitating urgent interventions to address drug resistance and improve treatment efficacy. In this…”
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Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation by Dogamanti, Ashok, Chiranjeevi, Pamula, Aamate, Vikas Kumar, Vagolu, Siva Krishna, Sriram, Dharmarajan, Balasubramanian, Sridhar, Sarasija, Madderla

“…As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids ( 7a–l ) were efficiently synthesized…”
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A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines by Ranjith Kumar, Raju, Perumal, Subbu, Senthilkumar, Palaniappan, Yogeeswari, Perumal, Sriram, Dharmarajan

“…An efficient synthesis of 1-methyl-3-[( E)-arylmethylidene]tetrahydro-4(1 H)-pyridinones was achieved by the reaction of 1-methyl-4-piperidone and aromatic…”
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1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation by Ashok, Dongamanti, Chiranjeevi, Pamula, Kumar, Aamate Vikas, Sarasija, Madderla, Krishna, Vagolu Siva, Sriram, Dharmarajan, Balasubramanian, Sridhar

“…A facile and convenient approach has been designed for the synthesis of novel prototypes that possess the advantage of the two pharmacophores of chromene and…”
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