Search Results - "Sriraghavan, Kamaraj"

A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode by Srinivas, Sakthivel, Ashokkumar, Krishnan, Sriraghavan, Kamaraj, Senthil Kumar, Annamalai

“…As an alternate for the conventional glass-based pH sensor which is associated with problems like fragile nature, alkaline error, and potential drift, the…”
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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439) by Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L

“…Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structure–activity relationship (SAR) of the…”
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The activity of dispiro peroxides against Fasciola hepatica by Wang, Xiaofang, Zhao, Qingjie, Vargas, Mireille, Dong, Yuxiang, Sriraghavan, Kamaraj, Keiser, Jennifer, Vennerstrom, Jonathan L.

“…Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For…”
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Direct Access to Quinone-Fused 5-Substituted-1,4-Benzodiazepine Scaffolds from Azidoquinones with/without [1,2]-Azide-Nitrogen Migration: Mechanistic Insights by Krishnan, Ashokkumar, Kamaraj, Sriraghavan

“…Seven-membered nitrogen heterocycles have a strong influence in drug discovery due to their inherent 3D character, which allows the ability to explore a vast…”
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Reaction Course Dependent Regiospecific Transformation of 4‐Azido‐Coumarin into Coumarin C3‐C4 Fused Imidazole and 5‐Substituted‐1,4‐Benzodiazepine Scaffolds by Nagamani, Vediyappan, Kamaraj, Sriraghavan

“…Herein, we report an efficient route for coumarin C3‐C4 fused imidazole scaffolds via indium chloride‐mediated single‐step transformation of 4‐azido‐coumarin…”
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Exploring imidazo[4,5- g ]quinoline-4,9-dione derivatives as Acinetobacter baumannii efflux pump inhibitor: an in silico approach by Brindangnanam, Pownraj, Ashokkumar, Krishnan, Kamaraj, Sriraghavan, Coumar, Mohane Selvaraj

“…Antimicrobial resistance (AMR) is fast becoming a medical crisis affecting the entire global population. World Health Organization (WHO) statistics show that…”
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Electrochemical immobilization of ellagic acid phytochemical on MWCNT modified glassy carbon electrode surface and its efficient hydrazine electrocatalytic activity in neutral pH by Kumar, Annamalai Senthil, Shanmugam, Ranganathan, Vishnu, Nandimalla, Pillai, K. Chandrasekara, Kamaraj, Sriraghavan

“…Ellagic acid (EA) is a lactone and polyphenolic functional groups-containing phyto-chemical that has been widely used as an anti-oxidant, anti-cancer and…”
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An Unusual Electrochemical Reductive Cleavage of Azo Dye into Highly Redox Active Copolymeric Aniline Derivatives on a MWCNT Modified Electrode Surface at Neutral pH and Its Electroanalytical Features by Gayathri, Prakasam, Senthil Kumar, Annamalai, Kamaraj, Sriraghavan

“…Developments of new decomposition or degradation methods of environmentally hazardous azo dyes from textile industries are very important. Usually, strong…”
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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria by Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.

“…Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase…”
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Structure–Activity Relationship of Antischistosomal Ozonide Carboxylic Acids by Wu, Jianbo, Wang, Xiaofang, Chiu, Francis C. K, Häberli, Cécile, Shackleford, David M, Ryan, Eileen, Kamaraj, Sriraghavan, Bulbule, Vivek J, Wallick, Alexander I, Dong, Yuxiang, White, Karen L, Davis, Paul H, Charman, Susan A, Keiser, Jennifer, Vennerstrom, Jonathan L

“…Semisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity…”
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The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277) by Dong, Yuxiang, Wittlin, Sergio, Sriraghavan, Kamaraj, Chollet, Jacques, Charman, Susan A, Charman, William N, Scheurer, Christian, Urwyler, Heinrich, Santo Tomas, Josefina, Snyder, Christopher, Creek, Darren J, Morizzi, Julia, Koltun, Maria, Matile, Hugues, Wang, Xiaofang, Padmanilayam, Maniyan, Tang, Yuanqing, Dorn, Arnulf, Brun, Reto, Vennerstrom, Jonathan L

“…The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum…”
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Structure−Activity Relationship of an Ozonide Carboxylic Acid (OZ78) against Fasciola hepatica by Zhao, Qingjie, Vargas, Mireille, Dong, Yuxiang, Zhou, Lin, Wang, Xiaofang, Sriraghavan, Kamaraj, Keiser, Jennifer, Vennerstrom, Jonathan L

“…In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of our search for a trematocidal synthetic peroxide drug development…”
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439 by Shackleford, David M, Chiu, Francis C. K, Katneni, Kasiram, Blundell, Scott, McLaren, Jenna, Wang, Xiaofang, Zhou, Lin, Sriraghavan, Kamaraj, Alker, André M, Hunziker, Daniel, Scheurer, Christian, Zhao, Qingjie, Dong, Yuxiang, Möhrle, Jörg J, Abla, Nada, Matile, Hugues, Wittlin, Sergio, Vennerstrom, Jonathan L, Charman, Susan A

“…OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using…”
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Dispiro-1,2,4-trioxane Analogues of a Prototype Dispiro-1,2,4-trioxolane:  Mechanistic Comparators for Artemisinin in the Context of Reaction Pathways with Iron(II) by Tang, Yuanqing, Dong, Yuxiang, Wang, Xiaofang, Sriraghavan, Kamaraj, Wood, James K, Vennerstrom, Jonathan L

“…Single electron reduction of the 1,2,4-trioxane heterocycle of artemisinin (1) forms primary and secondary carbon-centered radicals. The complex structure of 1…”
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Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12) by Dong, Yuxiang, Sonawane, Yogesh, Maher, Steven P, Zeeman, Anne-Marie, Chaumeau, Victor, Vantaux, Amélie, Cooper, Caitlin A, Chiu, Francis C. K, Ryan, Eileen, McLaren, Jenna, Chen, Gong, Wittlin, Sergio, Witkowski, Benoît, Nosten, François, Sriraghavan, Kamaraj, Kyle, Dennis E, Kocken, Clemens H. M, Charman, Susan A, Vennerstrom, Jonathan L

“…The catechol derivative RC-12 (WR 27653) (1) is one of the few non-8-aminoquinolines with good activity against hypnozoites in the gold-standard Plasmodium…”
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A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease by Burnett, James C, Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G, Ruthel, Gordon, Hermone, Ann R, Nguyen, Tam L, Kenny, Tara A, Lane, Douglas J, McGrath, Connor F, Schmidt, James J, Vennerstrom, Jonathan L, Gussio, Rick, Šolaja, Bogdan A, Bavari, Sina

“…We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain…”
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Physicochemical Characterization of Creatine N-Methylguanidinium Salts by Gufford, Brandon T., Sriraghavan, Kamaraj, Miller, Nicholas J., Miller, Donald W., Gu, Xiaochen, Vennerstrom, Jonathan L., Robinson, Dennis H.

“…ABSTRACT Creatine is widely used as a dietary supplement for body builders to enhance athletic performance. As the monohydrate, its low solubility in water and…”
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Photo-Fries and Fries reaction of 5,8-dihydro-1-naphthyl esters by Sriraghavan, Kamaraj, Ramakrishnan, Vayalakkavoor T

“…Systematic studies were performed on the photo-Fries and the Fries reaction of aliphatic, aliphatic unsaturated, aromatic and aromatic unsaturated esters of…”
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A FACILE SYNTHESIS OF N-ARYL AZIRIDINES by Sriraghavan, Kamaraj, Ramakrishnan, Vayalakkavoor T.

“…Reaction of N-aryl-β-amino alcohols with p-toluenesulphonyl chloride under phase transfer catalytic condition gave the corresponding N-aryl aziridines in good…”
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9-Hydroxy-8-iodo-4-methyl-7,8,9,10-tetrahydrobenzo[h]coumarin by Chinnakali, K., Fun, H.-K., Sriraghavan, K., Ramakrishnan, V. T.

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