Search Results - "Srinivasulu, Mukta"
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A reciprocal feedback loop between HIF-1α and HPIP controls phenotypic plasticity in breast cancer cells
Published in Cancer letters (01-02-2022)“…While phenotypic plasticity is a critical factor contributing to tumor heterogeneity, molecular mechanisms underlying this process are largely unknown. Here we…”
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Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer
Published in PloS one (29-09-2017)“…Extracellular matrix degradation by matrix metalloproteinases (MMPs) is an important mechanism involved in tumor invasion and metastasis. Genetic variations of…”
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Expression profiling of luminal B breast tumor in Indian women
Published in Journal of cancer research and clinical oncology (01-11-2023)“…Purpose In this study, we aimed at profiling of luminal B breast cancer specific gene expression pattern in Indian women using mRNA-seq and validation based on…”
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HER-2/neu Status: A Neglected Marker of Prognostication and Management of Breast Cancer Patients in India
Published in Asian Pacific journal of cancer prevention : APJCP (2013)“…Background: Categorizing breast tumors based on the ER, PR and HER/Neu 2 receptor status is necessary in order to predict outcome and assist in management of…”
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HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways
Published in Cancer letters (10-10-2021)“…While cancer cells rewire metabolic pathways to sustain growth and survival under metabolic stress in solid tumors, the molecular mechanisms underlying these…”
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PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
Published in Cancer research (Chicago, Ill.) (01-01-2013)“…PTEN is a well-defined tumor suppressor gene that antagonizes the PI3K/Akt pathway to regulate a multitude of cellular processes, such as survival, growth,…”
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Synergistic effect of collagenase-1 gene polymorphisms in breast cancer
Published in PloS one (29-09-2017)“…Background Extracellular matrix degradation by matrix metalloproteinases (MMPs) is an important mechanism involved in tumor invasion and metastasis. Genetic…”
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Synergistic effect of collagenase-1
Published in PloS one (29-09-2017)“…Background Extracellular matrix degradation by matrix metalloproteinases (MMPs) is an important mechanism involved in tumor invasion and metastasis. Genetic…”
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Distinct genetic aberrations in oesophageal adeno and squamous carcinoma
Published in European journal of clinical investigation (01-12-2013)“…Background The two main oesophageal cancer subtypes namely adenocarcinoma and squamous cell carcinoma exhibit interesting clinical, pathological and…”
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Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer
Published in Tumor biology (01-05-2016)“…BCL2 (B-cell leukemia/lymphoma 2) gene functions as antiapoptotic regulatory element and known to be associated with tumorigenesis. The SNP-938 (C>A)…”
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Evidence for possible non-canonical pathway(s) driven early-onset colorectal cancer in India
Published in Molecular carcinogenesis (01-02-2014)“…Two genetic instability pathways viz. chromosomal instability, driven primarily by APC mutation induced deregulated Wnt signaling, and microsatellite…”
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Her-2/neu status: a neglected marker of prognostication and management of breast cancer patients in India
Published in Asian Pacific journal of cancer prevention : APJCP (01-01-2013)“…Categorizing breast tumors based on the ER, PR and HER/Neu 2 receptor status is necessary in order to predict outcome and assist in management of breast…”
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Abstract 3692: Transcriptome analysis of oral tongue cancer reveals novel insights into wild type and mutant TP53 transcription program
Published in Cancer research (Chicago, Ill.) (15-07-2016)“…Abstract The p53 oncoprotein is a tumor suppressor that is stabilized upon various forms of cellular stresses to induce transcription of genes regulating cell…”
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Abstract 1883: Clinical and molecular genetic analysis of squamous cell carcinoma of the oral tongue
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract Squamous cell carcinoma of tongue (SCCT) is a common form of head and neck squamous cell carcinoma (HNSCC) in developing countries, mainly in India…”
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Overexpression of aldose reductase in human cancer tissues
Published in Medical science monitor (01-12-2006)“…Aldose reductase (AR) belongs to the aldo-keto reductase (AKR) super family and catalyzes the conversion of aldoses to the corresponding alcohol. Some recent…”
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Abstract 1198: Presence of non-canonical tumorigenesis pathways in early-onset sporadic rectal cancer
Published in Cancer research (Chicago, Ill.) (15-04-2013)“…Abstract Chromosomal instability (CIN) caused by β-Catenin dependent aberrant activation of canonical Wnt signaling or Microsatellite instability (MSI)…”
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Abstract 1216: Analysis of genetic aberrations in squamous cell carcinoma of the oral tongue
Published in Cancer research (Chicago, Ill.) (15-04-2013)“…Abstract Squamous cell carcinoma of the oral tongue (SCCOT) is a common form of head and neck squamous cell carcinoma (HNSCC). In the last few decades, a…”
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Variations in the Histopathologic Type of Esophageal Carcinoma Between the United States of America and India
Published in Indian journal of surgical oncology (01-03-2016)“…The aim of this study was to compare the incidence of the different histopathologic types of esophageal carcinoma between the United States of American (US)…”
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P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue
Published in BMC clinical pathology (09-08-2014)“…Squamous cell carcinoma of tongue (SCCT) is expected to harbor unique clinico-pathological and molecular genetic features since a significant proportion of…”
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