Search Results - "Srinivasan, Shushrruth Sai"

scENCORE: leveraging single-cell epigenetic data to predict chromatin conformation using graph embedding by Duan, Ziheng, Xu, Siwei, Sai Srinivasan, Shushrruth, Hwang, Ahyeon, Lee, Che Yu, Yue, Feng, Gerstein, Mark, Luan, Yu, Girgenti, Matthew, Zhang, Jing

“…Abstract Dynamic compartmentalization of eukaryotic DNA into active and repressed states enables diverse transcriptional programs to arise from a single…”
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InsuLock: A Weakly Supervised Learning Approach for Accurate Insulator Prediction, and Variant Impact Quantification by Srinivasan, Shushrruth Sai, Gong, Yanwen, Xu, Siwei, Hwang, Ahyeon, Xu, Min, Girgenti, Matthew J, Zhang, Jing

“…Mapping chromatin insulator loops is crucial to investigating genome evolution, elucidating critical biological functions, and ultimately quantifying variant…”
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scEpiLock: A Weakly Supervised Learning Framework for cis -Regulatory Element Localization and Variant Impact Quantification for Single-Cell Epigenetic Data by Gong, Yanwen, Srinivasan, Shushrruth Sai, Zhang, Ruiyi, Kessenbrock, Kai, Zhang, Jing

“…Recent advances in single-cell transposase-accessible chromatin using a sequencing assay (scATAC-seq) allow cellular heterogeneity dissection and regulatory…”
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Gene networks and systems biology in Alzheimer's disease: Insights from multi‐omics approaches by Rahimzadeh, Negin, Srinivasan, Shushrruth Sai, Zhang, Jing, Swarup, Vivek

“…Despite numerous studies in the field of dementia and Alzheimer's disease (AD), a comprehensive understanding of this devastating disease remains elusive. Bulk…”
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Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease by Miyoshi, Emily, Morabito, Samuel, Henningfield, Caden M., Das, Sudeshna, Rahimzadeh, Negin, Shabestari, Sepideh Kiani, Michael, Neethu, Emerson, Nora, Reese, Fairlie, Shi, Zechuan, Cao, Zhenkun, Srinivasan, Shushrruth Sai, Scarfone, Vanessa M., Arreola, Miguel A., Lu, Jackie, Wright, Sierra, Silva, Justine, Leavy, Kelsey, Lott, Ira T., Doran, Eric, Yong, William H., Shahin, Saba, Perez-Rosendahl, Mari, Head, Elizabeth, Green, Kim N., Swarup, Vivek

“…The pathogenesis of Alzheimer’s disease (AD) depends on environmental and heritable factors, with its molecular etiology still unclear. Here we present a…”
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