Search Results - "Srinivasan, Shriya S"

Closed-loop functional optogenetic stimulation by Srinivasan, Shriya S., Maimon, Benjamin E., Diaz, Maurizio, Song, Hyungeun, Herr, Hugh M.

“…Optogenetics has been used to orchestrate temporal- and tissue-specific control of neural tissues and offers a wealth of unique advantages for neuromuscular…”
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A cutaneous mechanoneural interface for neuroprosthetic feedback by S Srinivasan, Shriya, M Herr, Hugh

“…Amputation destroys sensory end organs and does not provide an anatomical interface for cutaneous neuroprosthetic feedback. Here, we report the design and a…”
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Resting state neurophysiology of agonist–antagonist myoneural interface in persons with transtibial amputation by Chicos, Laura A., Rangaprakash, D., Srinivasan, Shriya S., Gutierrez-Arango, Samantha, Song, Hyungeun, Barry, Robert L., Herr, Hugh M.

“…The agonist–antagonist myoneural interface (AMI) is an amputation surgery that preserves sensorimotor signaling mechanisms of the central-peripheral nervous…”
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Gold Nanoparticle-Based Fluorescent Theranostics for Real-Time Image-Guided Assessment of DNA Damage and Repair by Srinivasan, Shriya S, Seenivasan, Rajesh, Condie, Allison, Gerson, Stanton L, Wang, Yanming, Burda, Clemens

“…Chemotherapeutic dosing, is largely based on the tolerance levels of toxicity today. Molecular imaging strategies can be leveraged to quantify DNA cytotoxicity…”
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The Ewing Amputation: The First Human Implementation of the Agonist-Antagonist Myoneural Interface by Clites, Tyler R., Herr, Hugh M., Srinivasan, Shriya S., Zorzos, Anthony N., Carty, Matthew J.

“…The agonist-antagonist myoneural interface (AMI) comprises a surgical construct and neural control architecture designed to serve as a bidirectional interface,…”
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Pre-emptive Innovation Infrastructure for Medical Emergencies: Accelerating Healthcare Innovation in the Wake of a Global Pandemic by Ramadi, Khalil B., Srinivasan, Shriya S.

“…Healthcare innovation is impeded by high costs, the need for diverse skillsets, and complex regulatory processes. The COVID-19 pandemic exposed critical gaps…”
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Agonist-antagonist muscle strain in the residual limb preserves motor control and perception after amputation by Song, Hyungeun, Israel, Erica A., Gutierrez-Arango, Samantha, Teng, Ashley C., Srinivasan, Shriya S., Freed, Lisa E., Herr, Hugh M.

“…Background Elucidating underlying mechanisms in subject-specific motor control and perception after amputation could guide development of advanced surgical and…”
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Electroceuticals in the Gastrointestinal Tract by Ramadi, Khalil B., Srinivasan, Shriya S., Traverso, Giovanni

“…The field of electroceuticals has attracted considerable attention over the past few decades as a novel therapeutic modality. The gastrointestinal (GI) tract…”
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Towards functional restoration for persons with limb amputation: A dual-stage implementation of regenerative agonist-antagonist myoneural interfaces by Srinivasan, Shriya S., Diaz, Maurizio, Carty, Matthew, Herr, Hugh M.

“…While amputation has traditionally been viewed as a failure of therapy, recent developments in amputation surgery and neural interfacing demonstrate improved…”
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Patient-Centered Frameworks for Pain Neuromodulation Therapy: Overcoming Commercial and Regulatory Constraints to Optimize Therapy for Neural Interfaces by Srinivasan, Shriya S, Venkatasubramanian, Arun, North, Richard, Konrad, Peter

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Design of a Precision Medication Dispenser: Preventing Overdose by Increasing Accuracy and Precision of Dosage by Srinivasan, Shriya S., Kantareddy, Sai N. R., Nkwate, Ebenezer A., Meka, Praveen, Chang, Ivy, Hanumara, Nevan C., Ramadi, Khalil B.

“…Liquid medication overdose in pediatric patients results in over 70 000 visits to the emergency room yearly in the USA. Various studies have demonstrated that…”
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RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract by Srinivasan, Shriya S, Alshareef, Amro, Hwang, Alexandria V, Kang, Ziliang, Kuosmanen, Johannes, Ishida, Keiko, Jenkins, Joshua, Liu, Sabrina, Madani, Wiam Abdalla Mohammed, Lennerz, Jochen, Hayward, Alison, Morimoto, Josh, Fitzgerald, Nina, Langer, Robert, Traverso, Giovanni

“…Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration…”
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Respiratory Care Innovation in Times of Crisis by Srinivasan, Shriya S., Mondal, Rajib, Ramadi, Khalil B.

“…System-based modifications such as resistors, clamps, and valves have enabled varying levels of control in carefully matched patients.10,11 In addition, the…”
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Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation by Srinivasan, Shriya S., Gutierrez-Arango, Samantha, Teng, Ashley Chia-En, Israel, Erica, Song, Hyungeun, Bailey, Zachary Keith, Carty, Matthew J., Freed, Lisa E., Herr, Hugh M.

“…Despite advancements in prosthetic technologies, patients with amputation today suffer great diminution in mobility and quality of life. We have developed a…”
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Agonist-antagonist Myoneural Interfaces in Above-knee Amputation Preserve Distal Joint Function and Perception by Srinivasan, Shriya S., Herr, Hugh M., Clites, Tyler R., Gutierrez-Arango, Samantha, Teng, Ashley, Beltran, Luis, Song, Hyungeun, Israel, Erica, Carty, Matthew J.

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The Case for Neurosurgical Intervention in Cancer Neuroscience by Bernstock, Joshua D, Gerstl, Jakob V E, Chen, Jason A, Johnston, Benjamin R, Nonnenbroich, Leo F, Spanehl, Lennard, Gessler, Florian A, Valdes, Pablo A, Lu, Yi, Srinivasan, Shriya S, Smith, Timothy R, Peruzzi, Pierpaolo, Rolston, John D, Stone, Scellig, Chiocca, E Antonio

“…The emerging field of cancer neuroscience reshapes our understanding of the intricate relationship between the nervous system and cancer biology; this new…”
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Low-cost gastrointestinal manometry via silicone–liquid-metal pressure transducers resembling a quipu by Nan, Kewang, Babaee, Sahab, Chan, Walter W., Kuosmanen, Johannes L. P., Feig, Vivian R., Luo, Yiyue, Srinivasan, Shriya S., Patterson, Christina M., Jebran, Ahmad Mujtaba, Traverso, Giovanni

“…The evaluation of the tone and contractile patterns of the gastrointestinal (GI) tract via manometry is essential for the diagnosis of GI motility disorders…”
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Caprine Models of the Agonist-Antagonist Myoneural Interface Implemented at the Above- and Below-Knee Amputation Levels by Clites, Tyler R., Carty, Matthew J., Srinivasan, Shriya S., Talbot, Simon G., Brånemark, Rickard, Herr, Hugh M.

“…Traditional approaches to amputation are not capable of reproducing the dynamic muscle relationships that are essential for proprioceptive sensation and joint…”
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Location-aware ingestible microdevices for wireless monitoring of gastrointestinal dynamics by Sharma, Saransh, Ramadi, Khalil B., Poole, Nikhil H., Srinivasan, Shriya S., Ishida, Keiko, Kuosmanen, Johannes, Jenkins, Josh, Aghlmand, Fatemeh, Swift, Margaret B., Shapiro, Mikhail G., Traverso, Giovanni, Emami, Azita

“…Localization and tracking of ingestible microdevices in the gastrointestinal (GI) tract is valuable for the diagnosis and treatment of GI disorders. Such…”
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A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety by Srinivasan, Shriya S, Alshareef, Amro, Hwang, Alexandria, Byrne, Ceara, Kuosmanen, Johannes, Ishida, Keiko, Jenkins, Joshua, Liu, Sabrina, Madani, Wiam Abdalla Mohammed, Hayward, Alison M, Fabian, Niora, Traverso, Giovanni

“…Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with…”
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