Search Results - "Srinivasan, Preethi"

Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade by Abida, Wassim, Cheng, Michael L, Armenia, Joshua, Middha, Sumit, Autio, Karen A, Vargas, Hebert Alberto, Rathkopf, Dana, Morris, Michael J, Danila, Daniel C, Slovin, Susan F, Carbone, Emily, Barnett, Ethan S, Hullings, Melanie, Hechtman, Jaclyn F, Zehir, Ahmet, Shia, Jinru, Jonsson, Philip, Stadler, Zsofia K, Srinivasan, Preethi, Laudone, Vincent P, Reuter, Victor, Wolchok, Jedd D, Socci, Nicholas D, Taylor, Barry S, Berger, Michael F, Kantoff, Philip W, Sawyers, Charles L, Schultz, Nikolaus, Solit, David B, Gopalan, Anuradha, Scher, Howard I

“…The anti-programmed cell death protein 1 (PD-1) antibody pembrolizumab is approved by the US Food and Drug Administration for the treatment of microsatellite…”
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Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing by Hensley, Martee L, Chavan, Shweta S, Solit, David B, Murali, Rajmohan, Soslow, Robert, Chiang, Sarah, Jungbluth, Achim A, Bandlamudi, Chaitanya, Srinivasan, Preethi, Tap, William D, Rosenbaum, Evan, Taylor, Barry S, Donoghue, Mark T A, Hyman, David M

“…We examined whether prospective molecular characterization of advanced metastatic disease can reveal grade and/or histology-specific differences to inform…”
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The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D by Chaikovsky, Andrea C., Li, Chuan, Jeng, Edwin E., Loebell, Samuel, Lee, Myung Chang, Murray, Christopher W., Cheng, Ran, Demeter, Janos, Swaney, Danielle L., Chen, Si-Han, Newton, Billy W., Johnson, Jeffrey R., Drainas, Alexandros P., Shue, Yan Ting, Seoane, Jose A., Srinivasan, Preethi, He, Andy, Yoshida, Akihiro, Hipkins, Susan Q., McCrea, Edel, Poltorack, Carson D., Krogan, Nevan J., Diehl, J. Alan, Kong, Christina, Jackson, Peter K., Curtis, Christina, Petrov, Dmitri A., Bassik, Michael C., Winslow, Monte M., Sage, Julien

“…The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the…”
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CLINICAL UTILITY OF PROSPECTIVE MOLECULAR CHARACTERIZATION IN ADVANCED ENDOMETRIAL CANCER by Soumerai, Tara E, Donoghue, Mark T A, Bandlamudi, Chaitanya, Srinivasan, Preethi, Chang, Matthew T, Zamarin, Dmitriy, Cadoo, Karen, Grisham, Rachel, O'Cearbhaill, Roisin E, Tew, William, Konner, Jason, Hensley, Martee L, Makker, Vicky, Sabbatini, Paul J, Spriggs, David R, Troso-Sandoval, Tiffany, Snyder Charen, Alexandra, Friedman, Claire F, Gorsky, Mila, Schweber, Sarah J, Middha, Sumit, Murali, Rajmohan, Chiang, Sarah, Park, Kay J, Soslow, Robert A, Ladanyi, Marc, Li, Bob T, Mueller, Jennifer J, Weigelt, Britta, Zehir, Ahmet, Berger, Michael F, Abu-Rustum, Nadeem R, Aghajanian, Carol, DeLair, Deborah, Solit, David B, Taylor, Barry S, Hyman, David M

“…Advanced-stage endometrial cancers have limited treatment options and poor prognosis, highlighting the need to understand genetic drivers of therapeutic…”
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Multiplex picoliter-droplet digital PCR for quantitative assessment of DNA integrity in clinical samples by Didelot, Audrey, Kotsopoulos, Steve K, Lupo, Audrey, Pekin, Deniz, Li, Xinyu, Atochin, Ivan, Srinivasan, Preethi, Zhong, Qun, Olson, Jeff, Link, Darren R, Laurent-Puig, Pierre, Blons, Hélène, Hutchison, J Brian, Taly, Valerie

“…Assessment of DNA integrity and quantity remains a bottleneck for high-throughput molecular genotyping technologies, including next-generation sequencing. In…”
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Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients by Tsui, Dana W Y, Cheng, Michael L, Shady, Maha, Yang, Julie L, Stephens, Dennis, Won, Helen, Srinivasan, Preethi, Huberman, Kety, Meng, Fanli, Jing, Xiaohong, Patel, Juber, Hasan, Maysun, Johnson, Ian, Gedvilaite, Erika, Houck-Loomis, Brian, Socci, Nicholas D, Selcuklu, S Duygu, Seshan, Venkatraman E, Zhang, Hongxin, Chakravarty, Debyani, Zehir, Ahmet, Benayed, Ryma, Arcila, Maria, Ladanyi, Marc, Funt, Samuel A, Feldman, Darren R, Li, Bob T, Razavi, Pedram, Rosenberg, Jonathan, Bajorin, Dean, Iyer, Gopa, Abida, Wassim, Scher, Howard I, Rathkopf, Dana, Viale, Agnes, Berger, Michael F, Solit, David B

“…Cell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in…”
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Diagnostic Challenges of Uncommon Paediatric Head and Neck Masses- A Case Series by Karthik Sigamani, Preethi Srinivasan

“…Paediatric head and neck masses pose diagnostic challenge to the clinicians owing to the wide spectrum of lesions including congenital (developmental),…”
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Diagnostic Challenges of Uncommon Paediatric Head and Neck MassesA Case Series by Sigamani, Karthik, Srinivasan, Preethi

“…Paediatric head and neck masses pose diagnostic challenge to the clinicians owing to the wide spectrum of lesions including congenital (developmental),…”
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Disability, culture, and erased sexuality: curated raw narratives of disabled women with significant impairments in India by Srinivasan, Preethi, Karah, Hemachandran, Srinivasan, Sujatha

“…Disabled women with significant impairments (DWSI) are not adequately recognised within feminist disability studies. They face stigma, carnal taboos, and…”
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Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer by Latham, Alicia, Srinivasan, Preethi, Kemel, Yelena, Shia, Jinru, Bandlamudi, Chaitanya, Mandelker, Diana, Middha, Sumit, Hechtman, Jaclyn, Zehir, Ahmet, Dubard-Gault, Marianne, Tran, Christina, Stewart, Carolyn, Sheehan, Margaret, Penson, Alexander, DeLair, Deborah, Yaeger, Rona, Vijai, Joseph, Mukherjee, Semanti, Galle, Jesse, Dickson, Mark A, Janjigian, Yelena, O'Reilly, Eileen M, Segal, Neil, Saltz, Leonard B, Reidy-Lagunes, Diane, Varghese, Anna M, Bajorin, Dean, Carlo, Maria I, Cadoo, Karen, Walsh, Michael F, Weiser, Martin, Aguilar, Julio Garcia, Klimstra, David S, Diaz, Jr, Luis A, Baselga, Jose, Zhang, Liying, Ladanyi, Marc, Hyman, David M, Solit, David B, Robson, Mark E, Taylor, Barry S, Offit, Kenneth, Berger, Michael F, Stadler, Zsofia K

“…Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing has traditionally been performed in patients with colorectal (CRC) and…”
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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients by Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H, Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R, Srinivasan, Preethi, Gao, Jianjiong, Chakravarty, Debyani, Devlin, Sean M, Hellmann, Matthew D, Barron, David A, Schram, Alison M, Hameed, Meera, Dogan, Snjezana, Ross, Dara S, Hechtman, Jaclyn F, DeLair, Deborah F, Yao, JinJuan, Mandelker, Diana L, Cheng, Donavan T, Chandramohan, Raghu, Mohanty, Abhinita S, Ptashkin, Ryan N, Jayakumaran, Gowtham, Prasad, Meera, Syed, Mustafa H, Rema, Anoop Balakrishnan, Liu, Zhen Y, Nafa, Khedoudja, Borsu, Laetitia, Sadowska, Justyna, Casanova, Jacklyn, Bacares, Ruben, Kiecka, Iwona J, Razumova, Anna, Son, Julie B, Stewart, Lisa, Baldi, Tessara, Mullaney, Kerry A, Al-Ahmadie, Hikmat, Vakiani, Efsevia, Abeshouse, Adam A, Penson, Alexander V, Jonsson, Philip, Camacho, Niedzica, Chang, Matthew T, Won, Helen H, Gross, Benjamin E, Kundra, Ritika, Heins, Zachary J, Chen, Hsiao-Wei, Phillips, Sarah, Zhang, Hongxin, Wang, Jiaojiao, Ochoa, Angelica, Wills, Jonathan, Eubank, Michael, Thomas, Stacy B, Gardos, Stuart M, Reales, Dalicia N, Galle, Jesse, Durany, Robert, Cambria, Roy, Abida, Wassim, Cercek, Andrea, Feldman, Darren R, Gounder, Mrinal M, Hakimi, A Ari, Harding, James J, Iyer, Gopa, Janjigian, Yelena Y, Jordan, Emmet J, Kelly, Ciara M, Lowery, Maeve A, Morris, Luc G T, Omuro, Antonio M, Raj, Nitya, Razavi, Pedram, Shoushtari, Alexander N, Shukla, Neerav, Soumerai, Tara E, Varghese, Anna M, Yaeger, Rona, Coleman, Jonathan, Bochner, Bernard, Riely, Gregory J, Saltz, Leonard B, Scher, Howard I, Sabbatini, Paul J, Robson, Mark E, Klimstra, David S, Taylor, Barry S, Baselga, Jose, Schultz, Nikolaus, Hyman, David M, Arcila, Maria E, Solit, David B, Ladanyi, Marc, Berger, Michael F

“…MSK-IMPACT is a clinical sequencing platform able to detect genomic mutations, copy number alterations and structural variants in a panel of cancer-related…”
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Tumour lineage shapes BRCA-mediated phenotypes by Jonsson, Philip, Bandlamudi, Chaitanya, Cheng, Michael L., Srinivasan, Preethi, Chavan, Shweta S., Friedman, Noah D., Rosen, Ezra Y., Richards, Allison L., Bouvier, Nancy, Selcuklu, S. Duygu, Bielski, Craig M., Abida, Wassim, Mandelker, Diana, Birsoy, Ozge, Zhang, Liying, Zehir, Ahmet, Donoghue, Mark T. A., Baselga, José, Offit, Kenneth, Scher, Howard I., O’Reilly, Eileen M., Stadler, Zsofia K., Schultz, Nikolaus, Socci, Nicholas D., Viale, Agnes, Ladanyi, Marc, Robson, Mark E., Hyman, David M., Berger, Michael F., Solit, David B., Taylor, Barry S.

“…Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers 1 – 3 , and disease-specific screening and preventative strategies have reduced cancer…”
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A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers by Cercek, Andrea, Chatila, Walid K, Yaeger, Rona, Walch, Henry, Fernandes, Gustavo Dos Santos, Krishnan, Asha, Palmaira, Lerie, Maio, Anna, Kemel, Yelena, Srinivasan, Preethi, Bandlamudi, Chaitanya, Salo-Mullen, Erin, Tejada, Prince R, Belanfanti, Kimeisha, Galle, Jesse, Joseph, Vijai, Segal, Neil, Varghese, Anna, Reidy-Lagunes, Diane, Shia, Jinru, Vakiani, Efsevia, Mondaca, Sebastian, Mendelsohn, Robin, Lumish, Melissa A, Steinruecke, Felix, Kemeny, Nancy, Connell, Louise, Ganesh, Karuna, Markowitz, Arnold, Nash, Garrett, Guillem, Jose, Smith, J Joshua, Paty, Phillip B, Zhang, Liying, Mandelker, Diana, Birsoy, Ozge, Robson, Mark, Offit, Kenneth, Taylor, Barry, Berger, Michael, Solit, David, Weiser, Martin, Saltz, Leonard B, Aguilar, Julio Garcia, Schultz, Nikolaus, Diaz, Luis A, Stadler, Zsofia K

“…The causative factors for the recent increase in early-onset colorectal cancer (EO-CRC) incidence are unknown. We sought to determine if early-onset disease is…”
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Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS by Rose Brannon, A., Jayakumaran, Gowtham, Diosdado, Monica, Patel, Juber, Razumova, Anna, Hu, Yu, Meng, Fanli, Haque, Mohammad, Sadowska, Justyna, Murphy, Brian J., Baldi, Tessara, Johnson, Ian, Ptashkin, Ryan, Hasan, Maysun, Srinivasan, Preethi, Rema, Anoop Balakrishnan, Rijo, Ivelise, Agarunov, Aaron, Won, Helen, Perera, Dilmi, Brown, David N., Samoila, Aliaksandra, Jing, Xiaohong, Gedvilaite, Erika, Yang, Julie L., Stephens, Dennis P., Dix, Jenna-Marie, DeGroat, Nicole, Nafa, Khedoudja, Syed, Aijazuddin, Li, Alan, Lebow, Emily S., Bowman, Anita S., Ferguson, Donna C., Liu, Ying, Mata, Douglas A., Sharma, Rohit, Yang, Soo-Ryum, Bale, Tejus, Benhamida, Jamal K., Chang, Jason C., Dogan, Snjezana, Hameed, Meera R., Hechtman, Jaclyn F., Moung, Christine, Ross, Dara S., Vakiani, Efsevia, Vanderbilt, Chad M., Yao, JinJuan, Razavi, Pedram, Smyth, Lillian M., Chandarlapaty, Sarat, Iyer, Gopa, Abida, Wassim, Harding, James J., Krantz, Benjamin, O’Reilly, Eileen, Yu, Helena A., Li, Bob T., Rudin, Charles M., Diaz, Luis, Solit, David B., Arcila, Maria E., Ladanyi, Marc, Loomis, Brian, Tsui, Dana, Berger, Michael F., Zehir, Ahmet, Benayed, Ryma

“…Circulating cell-free DNA from blood plasma of cancer patients can be used to non-invasively interrogate somatic tumor alterations. Here we develop MSK-ACCESS…”
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Di-PriDA: Differentially Private Distributed Load Balancing Control for the Smart Grid by Liao, Xiaojing, Srinivasan, Preethi, Formby, David, Beyah, Raheem A.

“…The future electrical grid, i.e., smart grid, is envisioned to use appliance-level control to provide sustainable power usage and flexible energy utilization…”
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Comprehensive analysis of differentially methylated regions in colorectal cancer (CRC) by Solari, Omid, Constantin, Tudor, Jiang, Yuqian, Chan, Wengching, Tunc, Ilker, Srinivasan, Preethi, Kordi, Misagh, Santaguida, Marianne, Mitchell, Breeana L., Aleshin, Alexey, Swenerton, Ryan, Babiarz, Joshua, Kawli, Trupti, Reiter, Johannes G.

“…73 Background: Epigenetic alterations have been shown to govern many disease states, including cancer. A key epigenetic mark is the DNA methylation of CpGs…”
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Comparison of colorectal cancer (CRC) characteristics across genetic ancestries: Implications for early cancer detection (ECD) by Myer, Parvathi, Srinivasan, Preethi, Bristow, Sara L., Krinshpun, Shifra, Solari, Omid, Aushev, Vasily N., Jurdi, Adham A, Liu, Minetta C., Mitchell, Breeana L., Aleshin, Alexey, Reiter, Johannes G., Weitzel, Jeffrey N., Nakamura, Yoshiaki, Yoshino, Takayuki, Wall, Jeffrey, Ioannidis, Alexander, Bustamante, Carlos

“…164 Background: Blood-based ECD has the potential to reduce mortality rates by improving strategies for, adoption of, and adherence to screening. A deeper…”
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The context-specific role of germline pathogenicity in tumorigenesis by Srinivasan, Preethi, Bandlamudi, Chaitanya, Jonsson, Philip, Kemel, Yelena, Chavan, Shweta S., Richards, Allison L., Penson, Alexander V., Bielski, Craig M., Fong, Christopher, Syed, Aijazuddin, Jayakumaran, Gowtham, Prasad, Meera, Hwee, Jason, Sumer, Selcuk Onur, de Bruijn, Ino, Li, Xiang, Gao, JianJiong, Schultz, Nikolaus, Cambria, Roy, Galle, Jesse, Mukherjee, Semanti, Vijai, Joseph, Cadoo, Karen A., Carlo, Maria I., Walsh, Michael F., Mandelker, Diana, Ceyhan-Birsoy, Ozge, Shia, Jinru, Zehir, Ahmet, Ladanyi, Marc, Hyman, David M., Zhang, Liying, Offit, Kenneth, Robson, Mark E., Solit, David B., Stadler, Zsofia K., Berger, Michael F., Taylor, Barry S.

“…Human cancers arise from environmental, heritable and somatic factors, but how these mechanisms interact in tumorigenesis is poorly understood. Studying 17,152…”
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Clinical relevance of KRAS-mutated subclones detected with picodroplet digital PCR in advanced colorectal cancer treated with anti-EGFR therapy by Laurent-Puig, Pierre, Pekin, Deniz, Normand, Corinne, Kotsopoulos, Steve K, Nizard, Philippe, Perez-Toralla, Karla, Rowell, Rachel, Olson, Jeff, Srinivasan, Preethi, Le Corre, Delphine, Hor, Thevy, El Harrak, Zakaria, Li, Xinyu, Link, Darren R, Bouché, Olivier, Emile, Jean-François, Landi, Bruno, Boige, Valérie, Hutchison, J Brian, Taly, Valerie

“…KRAS mutations are predictive of nonresponse to anti-EGFR therapies in metastatic colorectal cancer (mCRC). However, only 50% of nonmutated patients benefit…”
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Serine starvation silences estrogen receptor signaling through histone hypoacetylation by Li, Albert M, He, Bo, Karagiannis, Dimitris, Li, Yang, Jiang, Haowen, Srinivasan, Preethi, Ramirez, Yaniel, Zhou, Meng-Ning, Curtis, Christina, Gruber, Joshua J, Lu, Chao, Rankin, Erinn B, Ye, Jiangbin

“…Loss of estrogen receptor (ER) pathway activity promotes breast cancer progression, yet how this occurs remains poorly understood. Here, we show that serine…”
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