Search Results - "Srinivasan, Jagan"
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Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior
Published in eLife (31-08-2022)“…Animals must weigh competing needs and states to generate adaptive behavioral responses to the environment. Sensorimotor circuits are thus tasked with…”
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Pan-neuronal imaging in roaming Caenorhabditis elegans
Published in Proceedings of the National Academy of Sciences - PNAS (23-02-2016)“…We present an imaging system for pan-neuronal recording in crawling Caenorhabditis elegans. A spinning disk confocal microscope, modified for automated…”
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Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles
Published in PLoS genetics (27-12-2022)“…The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant…”
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A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans
Published in PLoS biology (01-01-2012)“…The nematode C. elegans is an important model for the study of social behaviors. Recent investigations have shown that a family of small molecule signals, the…”
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5
Predator-secreted sulfolipids induce defensive responses in C. elegans
Published in Nature communications (19-03-2018)“…Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the…”
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shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans
Published in Proceedings of the National Academy of Sciences - PNAS (12-05-2009)“…Small molecule metabolites play important roles in Caenorhabditis elegans biology, but effective approaches for identifying their chemical structures are…”
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Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans
Published in Nature communications (18-07-2019)“…Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily…”
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Microfluidic chamber arrays for whole-organism behavior-based chemical screening
Published in Lab on a chip (01-01-2011)“…The nematode Caenorhabditis elegans is an important model organism in genetic research and drug screening because of its relative simplicity, ease of…”
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Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans
Published in Proceedings of the National Academy of Sciences - PNAS (08-03-2016)“…Animals find mates and food, and avoid predators, by navigating to regions within a favorable range of available sensory cues. How are these ranges set and…”
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Improved Synthesis for Modular Ascarosides Uncovers Biological Activity
Published in Organic letters (02-06-2017)“…A versatile synthesis of modular ascarosides, a family of signaling molecules from Caenorhabditis elegans and other nematodes, via hydrogenolysis of a cyclic…”
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Targeted Metabolomics Reveals a Male Pheromone and Sex-Specific Ascaroside Biosynthesis in Caenorhabditis elegans
Published in ACS chemical biology (17-08-2012)“…In the model organism Caenorhabditis elegans, a class of small molecule signals called ascarosides regulate development, mating, and social behaviors…”
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Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans
Published in eLife (22-09-2015)“…Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior?…”
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The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle
Published in Genetics (Austin) (01-04-2013)“…Nematodes compose an abundant and diverse invertebrate phylum with members inhabiting nearly every ecological niche. Panagrellus redivivus (the "microworm") is…”
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Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone
Published in Communications biology (31-08-2021)“…Dioecious species are a hallmark of the animal kingdom, with opposing sexes responding differently to identical sensory cues. Here, we study the response of C…”
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Trypanocide Use and Molecular Characterization of Trypanosomes Resistant to Diminazene Aceturate in Cattle in Northern Côte D'Ivoire
Published in Tropical medicine and infectious disease (01-09-2024)“…The resistance of trypanosomes to the doses of trypanocide administered by farmers to their animals acts as a real brake on efforts to control to combat…”
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Ascaroside Expression in Caenorhabditis elegans Is Strongly Dependent on Diet and Developmental Stage
Published in PloS one (15-03-2011)“…Background: The ascarosides form a family of small molecules that have been isolated from cultures of the nematode Caenorhabditis elegans. They are often…”
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Genetic Diversity of Trypanosomes Infesting Cattle from Savannah District in North of Côte d'Ivoire Using Conserved Genomic Signatures: rRNA, ITS1 and gGAPDH
Published in Pathogens (Basel) (01-03-2024)“…The potential danger to livestock from African animal trypanosomiasis is well known. However, the trypanosome species circulating in cattle and their genetics…”
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Synaptic polarity of the interneuron circuit controlling C. elegans locomotion
Published in Frontiers in computational neuroscience (02-10-2013)“…Caenorhabditis elegans is the only animal for which a detailed neural connectivity diagram has been constructed. However, synaptic polarities in this diagram,…”
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A comparison of experience-dependent locomotory behaviors and biogenic amine neurons in nematode relatives of Caenorhabditis elegans
Published in BMC neuroscience (19-02-2010)“…Survival of an animal depends on its ability to match its responses to environmental conditions. To generate an optimal behavioral output, the nervous system…”
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The cGMP signaling pathway affects feeding behavior in the necromenic nematode Pristionchus pacificus
Published in PloS one (26-04-2012)“…The genetic tractability and the species-specific association with beetles make the nematode Pristionchus pacificus an exciting emerging model organism for…”
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