Search Results - "Srinivasa Chakravarthy, V."
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Neurodegenerative Diseases - Is Metabolic Deficiency the Root Cause?
Published in Frontiers in neuroscience (31-03-2020)“…Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic lateral sclerosis, are a prominent class of neurological diseases…”
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Influence of energy deficiency on the subcellular processes of Substantia Nigra Pars Compacta cell for understanding Parkinsonian neurodegeneration
Published in Scientific reports (18-01-2021)“…Parkinson’s disease (PD) is the second most prominent neurodegenerative disease around the world. Although it is known that PD is caused by the loss of…”
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Modeling the development of cortical responses in primate dorsal ("where") pathway to optic flow using hierarchical neural field models
Published in Frontiers in neuroscience (22-05-2023)“…Although there is a plethora of modeling literature dedicated to the object recognition processes of the ventral ("what") pathway of primate visual systems,…”
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Artificial neurovascular network (ANVN) to study the accuracy vs. efficiency trade-off in an energy dependent neural network
Published in Scientific reports (05-07-2021)“…Artificial feedforward neural networks perform a wide variety of classification and function approximation tasks with high accuracy. Unlike their artificial…”
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A phenomenological model of whole brain dynamics using a network of neural oscillators with power-coupling
Published in Scientific reports (07-10-2023)“…We present a general, trainable oscillatory neural network as a large-scale model of brain dynamics. The model has a cascade of two stages - an oscillatory…”
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A computational model of neuro-glio-vascular loop interactions
Published in PloS one (20-11-2012)“…We present a computational, biophysical model of neuron-astrocyte-vessel interaction. Unlike other cells, neurons convey "hunger" signals to the vascular…”
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A Multi-Scale Computational Model of Excitotoxic Loss of Dopaminergic Cells in Parkinson's Disease
Published in Frontiers in neuroinformatics (30-09-2020)“…Parkinson's disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons in substantia nigra pars compacta (SNc). Although the exact…”
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Modeling hippocampal spatial cells in rodents navigating in 3D environments
Published in Scientific reports (19-07-2024)“…Studies on the neural correlates of navigation in 3D environments are plagued by several issues that need to be solved. For example, experimental studies show…”
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Interaction of network and rehabilitation therapy parameters in defining recovery after stroke in a Bilateral Neural Network
Published in Journal of neuroengineering and rehabilitation (19-12-2022)“…Restoring movement after hemiparesis caused by stroke is an ongoing challenge in the field of rehabilitation. With several therapies in use, there is no…”
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A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity
Published in Frontiers in neural circuits (25-02-2019)“…Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta…”
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Modeling the tonotopic map using a two-dimensional array of neural oscillators
Published in Frontiers in computational neuroscience (24-08-2022)“…We present a model of a tonotopic map known as the Oscillatory Tonotopic Self-Organizing Map (OTSOM). It is a 2-dimensional, self-organizing array of Hopf…”
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Probing the Role of Medication, DBS Electrode Position, and Antidromic Activation on Impulsivity Using a Computational Model of Basal Ganglia
Published in Frontiers in human neuroscience (12-09-2016)“…Everyday, we encounter situations where available choices are nearly equally rewarding (high conflict) calling for some tough decision making. Experimental…”
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A deep network-based model of hippocampal memory functions under normal and Alzheimer's disease conditions
Published in Frontiers in neural circuits (21-06-2023)“…We present a deep network-based model of the associative memory functions of the hippocampus. The proposed network architecture has two key modules: (1) an…”
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A generalized reinforcement learning based deep neural network agent model for diverse cognitive constructs
Published in Scientific reports (12-04-2023)“…Human cognition is characterized by a wide range of capabilities including goal-oriented selective attention, distractor suppression, decision making, response…”
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A Complex-Valued Oscillatory Neural Network for Storage and Retrieval of Multidimensional Aperiodic Signals
Published in Frontiers in computational neuroscience (24-05-2021)“…Recurrent neural networks with associative memory properties are typically based on fixed-point dynamics, which is fundamentally distinct from the oscillatory…”
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A Multi-Scale Computational Model of Levodopa-Induced Toxicity in Parkinson's Disease
Published in Frontiers in neuroscience (19-04-2022)“…Parkinson's disease (PD) is caused by the progressive loss of dopaminergic cells in substantia nigra pars compacta (SNc). The root cause of this cell loss in…”
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A Model of Motion Processing in the Visual Cortex Using Neural Field With Asymmetric Hebbian Learning
Published in Frontiers in neuroscience (12-02-2019)“…Neurons in the dorsal pathway of the visual cortex are thought to be involved in motion processing. The first site of motion processing is the primary visual…”
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The Influence of Neural Activity and Neural Cytoarchitecture on Cerebrovascular Arborization: A Computational Model
Published in Frontiers in neuroscience (04-07-2022)“…Normal functioning of the brain relies on a continual and efficient delivery of energy by a vast network of cerebral blood vessels. The bidirectional coupling…”
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A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions
Published in Frontiers in computational neuroscience (03-01-2022)“…In order to understand the link between substantia nigra pars compacta (SNc) cell loss and Parkinson's disease (PD) symptoms, we developed a multiscale…”
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A Network Architecture for Bidirectional Neurovascular Coupling in Rat Whisker Barrel Cortex
Published in Frontiers in computational neuroscience (15-06-2021)“…Neurovascular coupling is typically considered as a master-slave relationship between the neurons and the cerebral vessels: the neurons demand energy which the…”
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