Investigation of the photoluminescent properties, scintillation behaviour and toxicological profile of various magnesium tungstate nanoscale motifs

We have synthesized several morphologies and crystal structures of MgWO using a one-pot hydrothermal method, producing not only monoclinic stars and large nanoparticles but also triclinic wool balls and sub-10 nm nanoparticles. Herein we describe the importance of reaction parameters in demonstratin...

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Bibliographic Details
Published in:	Royal Society open science Vol. 9; no. 12; p. 220994
Main Authors:	Hurley, Nathaniel, Srinivas, Sailesh, Fang, Justin, Sun, Manli, Hong, Simon, Chien, Chia Te, Guo, Alan, Khan, Tamor A, Li, Mingxing, Cotlet, Mircea, Moretti, Federico, Bourret, Edith, Radin, Daniel, Tsirka, Stella E, Shelly, Maya, Wong, Stanislaus S
Format:	Journal Article
Language:	English
Published:	England The Royal Society Publishing 07-12-2022 The Royal Society
Subjects:	bioimaging Chemistry nanomaterials NANOSCIENCE AND NANOTECHNOLOGY oxides scintillation synthesis toxicology synthesis toxicology scintillation nanomaterials oxides bioimaging
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Summary:	We have synthesized several morphologies and crystal structures of MgWO using a one-pot hydrothermal method, producing not only monoclinic stars and large nanoparticles but also triclinic wool balls and sub-10 nm nanoparticles. Herein we describe the importance of reaction parameters in demonstrating morphology control of as-prepared MgWO . Moreover, we correlate structure and composition with the resulting photoluminescence and radioluminescence properties. Specifically, triclinic-phase samples yielded a photoluminescence emission of 421 nm, whereas monoclinic-phase materials gave rise to an emission maximum of 515 nm. The corresponding radioluminescence data were characterized by a broad emission peak, located at 500 nm for all samples. Annealing the wool balls and sub-10 nm particles to transform the crystal structure from a triclinic to a monoclinic phase yielded a radioluminescence (RL) emission signal that was two orders of magnitude greater than that of their unannealed counterparts. Finally, to confirm the practical utility of these materials for biomedical applications, a series of sub-10 nm particles, including as-prepared and annealed samples, were functionalized with biocompatible PEG molecules, and subsequently were found to be readily taken up by various cell lines as well as primary cultured hippocampal neurons with low levels of toxicity, thereby highlighting for the first time the potential of this particular class of metal oxides as viable and readily generated platforms for a range of biomedical applications.
Bibliography:	SC0012704; NS114914; NS119512; AC02–05CH11231 USDOE Office of Science (SC), Basic Energy Sciences (BES) National Institutes of Health (NIH) USDOE National Nuclear Security Administration (NNSA) BNL-223926-2023-JAAM Second e-mail: sswong@bnl.gov This article has been edited by the Royal Society of Chemistry, including the commissioning, peer review process and editorial aspects up to the point of acceptance. Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.6315600.
ISSN:	2054-5703 2054-5703
DOI:	10.1098/rsos.220994