Search Results - "Srinivas, Gangula"

Commercial-Scale Visible Light Trifluoromethylation of 2‑Chlorothiophenol Using CF3I Gas by Harper, Kaid C, Zhang, En-Xuan, Liu, Zhi-Qing, Grieme, Timothy, Towne, Timothy B, Mack, Daniel J, Griffin, Jeremy, Zheng, Song-Yuan, Zhang, Ning-Ning, Gangula, Srinivas, Yuan, Jia-Long, Miller, Robert, Huang, Ping-Zhong, Gage, James, Diwan, Moiz, Ku, Yi-Yin

“…Despite the growth of photoredox methods in academia, application of photoredox at scale in the pharmaceutical and fine chemical industries has been slow. In…”
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Investigation of a Kumada Cross Coupling Reaction for Large-Scale Production of (2S, 7R, E)‑2-Isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)‑N,N,8-trimethylnon-4-enamide by Gangula, Srinivas, Neelam, Uday Kumar, Baddam, Sudharkar Reddy, Dahanukar, Vilas H, Bandichhor, Rakeshwar

“…An investigation into the Kumada cross coupling reaction was conducted by developing a reliable, efficient procedure for the Grignard reagent and its…”
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An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate by Naveenkumar Kolla, Chandrashekar R. Elati, Pravinchandra J. Vankawala, Srinivas Gangula, Eswaraiah Sajja, Yerremilli Anjaneyulu, Apurba Bhattacharya, Venkataraman Sundaram, Vijayavitthal T. Mathad

“…The development of a large-scale synthesis for (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine (S-(+)-1), a key intermediate of repaglinide (2), is…”
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Commercial-Scale Visible Light Trifluoromethylation of 2-Chlorothiophenol Using CF 3 I Gas by Harper, Kaid C., Zhang, En-Xuan, Liu, Zhi-Qing, Grieme, Timothy, Towne, Timothy B., Mack, Daniel J., Griffin, Jeremy, Zheng, Song-Yuan, Zhang, Ning-Ning, Gangula, Srinivas, Yuan, Jia-Long, Miller, Robert, Huang, Ping-Zhong, Gage, James, Diwan, Moiz, Ku, Yi-Yin

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Synthesis, Optimization, and Large-Scale Preparation of the Low-Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3 + 2] Nitrone Cycloaddition by Garcia-Losada, Pablo, DeBaillie, Amy C, Eugenio de Diego, Jose, Green, Steven J, Hansen, Marvin M, Jaramillo, Carlos, Johnson, Matt, Kaoudi, Talbi, Li, Jiuyuan, Lindsay-Scott, Peter J, Mateos, Carlos, Mergott, Dustin J, Rincon, Juan Antonio, Rothhaar, Roger R, Seibert, Kevin D, Watson, Brian M, Winneroski, Leonard L, Gangula, Srinivas, Jing, Dajiang, Sun, Hao, Zhang, Lei, Frederick, Michael O

“…Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key…”
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Application of Continuous Flow Micromixing Reactor Technology for Synthesis of Benzimidazole Drugs by Reddy, Gunupati Sharathchandra, Reddy, Narra Santosh, Manudhane, Kushal, Rama Krishna, Medisetti Venkata, Ramachandra, Kopparapu Janardana Sarma, Gangula, Srinivas

“…Synthesis of pharmaceutically active compounds by employing continuous flow micromixing reactor technology is an interesting research area. In this article we…”
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Improved Process for Paroxetine Hydrochloride Substantially Free from Potential Impurities by Gangula, Srinivas, Kolla, Naveen Kumar, Elati, Chandrasekar, Dongamanti, Ashok, Bandichhor, Rakeshwar

“…An efficient process for production of paroxetine hydrochloride hemihydrate 1, a selective 5-hydroxytryptamine (serotonin) reuptake inhibitor, is described…”
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An efficient synthesis of dexlansoprazole employing asymmetric oxidation strategy by Raju, Manne Naga, Kumar, Neelam Uday, Reddy, Baddam Sudhakar, Anitha, Naredla, Srinivas, Gangula, Bhattacharya, Apurba, Mukkanti, Kagga, Kolla, Naveenkumar, Bandichhor, Rakeshwar

“…An alternative and scalable synthesis of dexlansoprazole (( R)-(+)- 1); the ( R)-enantiomer of Lansoprazole with an enantiomeric excess of >99.8% is presented…”
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An Improved Process for the Production of Lansoprazole: Investigation of Key Parameters That Influence the Water Content in Final API by Gangula, Srinivas, Elati, Chandrasekhar R, Neredla, Anitha, Baddam, Sudhakar R, Neelam, Uday Kumar, Bandichhor, Rakeshwar, Dongamanti, Ashok

“…An improved large-scale synthesis of lansoprazole 1 an anti-ulcer drug is described. The synthesis commences with condensation of 2-mercaptobenzimadazole 3…”
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Synthesis of All Enantiomerically Pure Diastereomers of Aprepitant by Gangula, Srinivas, Elati, Chandrashekhar R., Mudunuru, Satish Varma, Nardela, Anitha, Dongamanti, Ashok, Bhattacharya, Apurba, Bandichhor, Rakeshwar

“…Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and…”
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Novel Synthesis of Fosphenytoin: Anti-Convulsant Prodrug by Elati, Chandrashekar R., Gangula, Srinivas, Naredla, Anitha, Ashok, S., Bhattacharya, Apurba, Bandichhor, Rakeshwarar

“…A simple, new synthesis of fosphenytoin sodium 1, a prodrug, via imidate ester and employing mild reaction conditions is described…”
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A convergent approach to the synthesis of aprepitant: a potent human NK-1 receptor antagonist by Elati, Chandrashekar R., Kolla, Naveenkumar, Gangula, Srinivas, Naredla, Anitha, Vankawala, Pravinchandra J., Avinigiri, Muttu L., Chalamala, Subrahmanyeswararao, Sundaram, Venkatraman, Mathad, Vijayavitthal T., Bhattacharya, Apurba, Bandichhor, Rakeshwar

“…A convergent approach to enantiomerically pure aprepitant a potent orally active antagonist of the human neurokinin-1 (NK-1) receptor, is described. A simple…”
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An Alternative Approach to Achieve Enantiopure (3S)-4-Benzyl-3- (4-fluorophenyl)morpholin-2-one:  A Key Intermediate of Aprepitant, an NK1 Receptor Antagonist by Kolla, Naveenkumar, Elati, Chandrashekar R, Arunagiri, Muthulingam, Gangula, Srinivas, Vankawala, Pravinchandra J, Anjaneyulu, Yerremilli, Bhattacharya, Apurba, Venkatraman, Sundaram, Mathad, Vijayavitthal T

“…An efficient and alternative synthesis of enantiomerically pure (3S)-4-benzyl-3-(4-fluorophenyl)morpholin-2-one (S)-(+)-2), a key intermediate in the synthesis…”
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Substrate Modification Approach to Achieve Efficient Resolution:  Didesmethylcitalopram:  A Key Intermediate for Escitalopram by Elati, Chandrashekar R, Kolla, Naveenkumar, Vankawala, Pravinchandra J, Gangula, Srinivas, Chalamala, Subrahmanyeswarara, Sundaram, Venkatraman, Bhattacharya, Apurba, Vurimidi, Himabindu, Mathad, Vijayavitthal T

“…Research work presented here describes an approach to achieve the enantiopure escitalopram (1) via didesmethyl escitalopram (4), which is easily resolvable…”
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Substrate Modification Approach to Achieve Efficient Resolution:  Didesmethylcitalopram:  A Key Intermediate for Escitalopram by Elati, Chandrashekar R, Kolla, Naveenkumar, Vankawala, Pravinchandra J, Gangula, Srinivas, Chalamala, Subrahmanyeswarara, Sundaram, Venkatraman, Bhattacharya, Apurba, Vurimidi, Himabindu, Mathad, Vijayavitthal T

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