Search Results - "Srinivas, Chatla"

Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia by Wu, Limei, Chatla, Srinivas, Lin, Qiqi, Chowdhury, Fabliha Ahmed, Geldenhuys, Werner, Du, Wei

“…Chemoresistance posts a major hurdle for treatment of acute leukemia. There is increasing evidence that prolonged and intensive chemotherapy often fails to…”
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Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis by Lin, Qiqi, Wu, Limei, Chatla, Srinivas, Chowdhury, Fabliha A, Atale, Neha, Joseph, Jonathan, Du, Wei

“…The crosstalk between the BM microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration. Here, we show that in mice,…”
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Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice by Li, Xue, Chatla, Srinivas, Wilson, Andrew F, Wu, Limei, Atale, Neha, Du, Wei

“…The immune receptor TREM1 (Triggering receptor expressed on myeloid cells 1) is a master regulator of inflammatory response. Compelling evidence suggests…”
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Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation by Chatla, Srinivas, Du, Wei, Wilson, Andrew F., Meetei, Amom Ruhikanta, Pang, Qishen

“…Members of the Fanconi anemia (FA) protein family are involved in multiple cellular processes including response to DNA damage and oxidative stress. Here we…”
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ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias by Golovine, Konstantin, Abalakov, Gleb, Lian, Zhaorui, Chatla, Srinivas, Karami, Adam, Chitrala, Kumaraswamy Naidu, Madzo, Jozef, Nieborowska-Skorska, Margaret, Huang, Jian, Skorski, Tomasz

“…Deletion of ABL1 was detected in a cohort of hematologic malignancies carrying AML1-ETO and NUP98 fusion proteins. Abl1−/− murine hematopoietic cells…”
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Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer by Srinivas, Chatla, Ramaiah, M Janaki, Lavanya, A, Yerramsetty, Suresh, Kavi Kishor, P B, Basha, Shaik Anver, Kamal, Ahmed, Bhadra, Utpal, Bhadra, Manika-Pal

“…Tumor microenvironment play role in angiogenesis and carcinogenesis. Etoposide, a known topoisomerase II inhibitor induces DNA damage resulting in cell cycle…”
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Hematopoietic Stem Cell Regeneration through Paracrine Regulation of the Wnt5a-Prox1 Signaling Axis by Lin, Qiqi, Chatla, Srinivas, Wu, Limei, Chowdhury, Fabliha, Du, Wei

“…The crosstalk between bone marrow (BM) microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration after injury. Here we show…”
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LepR+ Niche Cell-Derived AREG Compromises Hematopoietic Stem Cell Maintenance Under Conditions of DNA Repair Deficiency and Aging by Wu, Limei, Lin, Qiqi, Chatla, Srinivas, Atale, Neha, Gao, Zhenxia J., Joseph, Jonathan, Wolff, Emily V., Du, Wei

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LepR+ niche cell–derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging by Wu, Limei, Lin, Qiqi, Chatla, Srinivas, Amarachintha, Surya, Wilson, Andrew F., Atale, Neha, Gao, Zhenxia J., Joseph, Jonathan, Wolff, Emily V., Du, Wei

“…•Persistent DNA damage induces AREG expression in BM LepR+ cells deficient of the Brca2 gene.•Overproduced AREG activates the PI3K/AKT/mTOR pathway, promotes…”
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Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer by Kumar, Sushil, Srivastav, Ratnesh Kumar, Wilkes, David W., Ross, Taylor, Kim, Sabrina, Kowalski, Jules, Chatla, Srinivas, Zhang, Qing, Nayak, Anupma, Guha, Manti, Fuchs, Serge Y., Thomas, Christoforos, Chakrabarti, Rumela

“…Aberrant Notch signaling is implicated in several cancers, including breast cancer. However, the mechanistic details of the specific receptors and function of…”
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R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts by Liu, Zhiyan Silvia, Sinha, Sayantani, Bannister, Maxwell, Song, Axia, Arriaga-Gomez, Erica, McKeeken, Alexander J, Bonner, Elizabeth A, Hanson, Benjamin K, Sarchi, Martina, Takashima, Kouhei, Zong, Dawei, Corral, Victor M, Nguyen, Evan, Yoo, Jennifer, Chiraphapphaiboon, Wannasiri, Leibson, Cassandra, McMahon, Matthew C, Rai, Sumit, Swisher, Elizabeth M, Sachs, Zohar, Chatla, Srinivas, Stirewalt, Derek L, Deeg, H Joachim, Skorski, Tomasz, Papapetrou, Eirini P, Walter, Matthew J, Graubert, Timothy A, Doulatov, Sergei, Lee, Stanley C, Nguyen, Hai Dang

“…RNA splicing factor (SF) gene mutations are commonly observed in patients with myeloid malignancies. Here we showed that SRSF2- and U2AF1-mutant leukemias are…”
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Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion by Chatla, Srinivas, Wilson, Andrew F, Pang, Qishen

“…Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and high risk of cancer particularly leukemia. Here we show that inactivation of…”
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DNA polymerase θ protects leukemia cells from metabolically induced DNA damage by Vekariya, Umeshkumar, Toma, Monika, Nieborowska-Skorska, Margaret, Le, Bac Viet, Caron, Marie-Christine, Kukuyan, Anna-Mariya, Sullivan-Reed, Katherine, Podszywalow-Bartnicka, Paulina, Chitrala, Kumaraswamy N., Atkins, Jessica, Drzewiecka, Malgorzata, Feng, Wanjuan, Chan, Joe, Chatla, Srinivas, Golovine, Konstantin, Jelinek, Jaroslav, Sliwinski, Tomasz, Ghosh, Jayashri, Matlawska-Wasowska, Ksenia, Chandramouly, Gurushankar, Nejati, Reza, Wasik, Mariusz, Sykes, Stephen M., Piwocka, Katarzyna, Hadzijusufovic, Emir, Valent, Peter, Pomerantz, Richard T., Morton, George, Childers, Wayne, Zhao, Huaqing, Paietta, Elisabeth M., Levine, Ross L., Tallman, Martin S., Fernandez, Hugo F., Litzow, Mark R., Gupta, Gaorav P., Masson, Jean-Yves, Skorski, Tomasz

“…•DNA POLθ–mediated DNA repair protects leukemia cells from the toxic effect of metabolically induced DNA damage.•DNA POLθ is a new therapeutic target to…”
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DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage by Vekariya, Umeshkumar, Toma, Monika Maria, Nieborowska-Skorska, Margaret, Le, Bac Viet, Caron, Marie-Christine, Kukuyan, Anna-Mariya, Sullivan-Reed, Katherine, Podszywalow-Bartnicka, Paulina, Chitrala, Kumaraswamy Naidu, Atkins, Jessica, Drzewiecka, Malgorzata, Feng, Wanjuan, Chan, Joe, Chatla, Srinivas, Golovine, Konstantin, Jelinek, Jaroslav, Sliwinski, Tomasz, Ghosh, Jayashri, Matlawska-Wasowska, Ksenia, Chandramouly, Gurushankar, Nejati, Reza, Wasik, Mariusz A, Sykes, Stephen, Piwocka, Katarzyna, Hadzijusufovic, Emir, Valent, Peter, Pomerantz, Richard T, Morton, George, Childers, Wayne, Zhao, Huaqing, Paietta, Elisabeth, Levine, Ross L., Tallman, Martin S., Fernandez, Hugo, Litzow, Mark R, Gupta, Gaorav, Masson, Jean-Yves, Skorski, Tomasz

“…Leukemia cells accumulate DNA damage but altered DNA repair mechanisms protect them from apoptosis. We showed here that formaldehyde generated by…”
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Scriptaid cause histone deacetylase inhibition and cell cycle arrest in HeLa cancer cells: A study on structural and functional aspects by Janaki Ramaiah, M., Naushad, Shaik Mohammad, Lavanya, A., Srinivas, Chatla, Anjana Devi, Tangutur, Sampathkumar, Sowganthika, Dharan, Dhepikha Bharani, Bhadra, Manika Pal

“…Scriptaid (SCR), a well-known histone deacetylase inhibitor, cause various cellular effects such as cell growth inhibition and apoptosis. In this study, we…”
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Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole–pyrrolo[2,1- c][1,4]benzodiazepine conjugates by Kamal, Ahmed, Reddy, K. Srinivasa, Khan, M. Naseer A., Shetti, Rajesh V.C.R.N.C., Ramaiah, M. Janaki, Pushpavalli, S.N.C.V.L., Srinivas, Chatla, Pal-Bhadra, Manika, Chourasia, Mukesh, Sastry, G. Narahari, Juvekar, Aarti, Zingde, Surekha, Barkume, Madan

“…A series of benzothiazole and benzoxazole linked pyrrolobenzodiazepine conjugates attached through different alkane or alkylamide spacers was prepared. Their…”
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Novel SAHA analogues inhibit HDACs, induce apoptosis and modulate the expression of microRNAs in hepatocellular carcinoma by Srinivas, Chatla, Swathi, V., Priyanka, C., Anjana Devi, T., Subba Reddy, B. V., Janaki Ramaiah, M., Bhadra, Utpal, Bhadra, Manika Pal

“…In eukaryotes, transcriptional regulation occurs via chromatin remodeling, mainly through post translational modifications of histones that package DNA into…”
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aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle by Chandrasekhar, Srivari, Pushpavalli, Sreerangam N.C.V.L., Chatla, Srinivas, Mukhopadhyay, Debasmita, Ganganna, Bogonda, Vijeender, Kandi, Srihari, Pabbaraja, Reddy, Chada Raji, Janaki Ramaiah, M., Bhadra, Utpal

“…aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species…”
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Synthesis of Imidazothiazole-Chalcone Derivatives as Anticancer and Apoptosis Inducing Agents by Kamal, Ahmed, Dastagiri, D., Ramaiah, M. Janaki, Reddy, J. Surendranadha, Bharathi, E. Vijaya, Srinivas, Chatla, Pushpavalli, S. N. C. V. L., Pal, Dhananjaya, Pal-Bhadra, Manika

“…A new class of imidazo[2,1‐b]thiazole chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives show…”
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Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer: e0142006 by Srinivas, Chatla, Ramaiah, M Janaki, Lavanya, A, Yerramsetty, Suresh, Kishor, P BKavi, Basha, Shaik Anver, Kamal, Ahmed, Bhadra, Utpal, Bhadra, Manika-Pal

“…Tumor microenvironment play role in angiogenesis and carcinogenesis. Etoposide, a known topoisomerase II inhibitor induces DNA damage resulting in cell cycle…”
Get full text