Search Results - "Srinivas, Akhila"
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Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy
Published in Bioorganic & medicinal chemistry letters (15-08-2018)“…[Display omitted] •Selective USP30 inhibitors.•Increase protein ubiquitination.•Accelerates mitophagy. Mitophagy is one of the processes that cells use to…”
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Abstract 1143: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that…”
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Abstract 1753: Targeting cancer with selective cbp/p300 bromodomain inhibitors
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract Background: The Bromodomain (BRD) and Extra-Terminal domain (BET) family of proteins are key regulators of epigenetic control. Although pan BET…”
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Abstract 1754: First in class orally bioavailable BETBRD degraders
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract Background: Inhibition of Bromodomain and extra-terminal (BET) family proteins by small molecules is actively being pursued as a therapeutic strategy…”
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Characterization of dolochar wastes generated by the sponge iron industry
Published in International journal of minerals, metallurgy and materials (01-11-2012)“…Solid wastes generated by the metallurgical industry contribute significantly towards the enhancement of environmental pollution. The handling, utilization,…”
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