Search Results - "Srini, V"
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IVIG-mediated effector functions in autoimmune and inflammatory diseases
Published in International immunology (30-12-2017)“…Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained from several thousand healthy donors. It is widely used in the immunotherapy…”
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Th17 Cells: Biology, Pathogenesis of Autoimmune and Inflammatory Diseases, and Therapeutic Strategies
Published in The American journal of pathology (01-07-2012)“…Th17 cells that secrete the cytokines IL-17A and IL-17F and express lineage-specific transcription factor RORC (RORγt in mice) represent a distinct lineage of…”
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Intravenous immunoglobulin: Exploiting the potential of natural antibodies
Published in Autoimmunity reviews (01-09-2012)“…Abstract Antibodies present in healthy conditions in the absence of deliberate immunization or infections are called natural antibodies. A significant…”
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Natural Antibodies: from First-Line Defense Against Pathogens to Perpetual Immune Homeostasis
Published in Clinical reviews in allergy & immunology (01-04-2020)“…Natural antibodies (nAbs) are most commonly defined as immunoglobulins present in the absence of pathological conditions or deliberate immunizations…”
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Passive Serum Therapy to Immunomodulation by IVIG: A Fascinating Journey of Antibodies
Published in The Journal of immunology (1950) (15-03-2018)“…The immunoregulatory and anti-infective properties of normal circulating polyclonal Abs have been exploited for the therapeutic purposes in the form of IVIG as…”
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Restoring immune tolerance in pemphigus vulgaris
Published in Proceedings of the National Academy of Sciences - PNAS (30-01-2024)“…Intravenous immunoglobulin (IVIg), a preparation of polyclonal serum IgG pooled from numerous blood donors, has been used for nearly three decades and is…”
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Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients
Published in Cell reports. Medicine (19-05-2020)“…Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has infected millions, with more than 275,000…”
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Kill ‘Em All: Efgartigimod Immunotherapy for Autoimmune Diseases
Published in Trends in pharmacological sciences (Regular ed.) (01-11-2018)“…Neonatal Fc receptors (FcRns) recycle IgGs by preventing their lysosome degradation. As this process also enhances half-life of pathogenic auto-IgG, inspired…”
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Surface hydrophobin prevents immune recognition of airborne fungal spores
Published in Nature (London) (27-08-2009)“…Breathe easy: why inhaled fungal spores don't provoke an immune reaction Every day we inhale thousands of tiny fungal spores (conidia), originating from many…”
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Natural IgM in immune equilibrium and harnessing their therapeutic potential
Published in The Journal of immunology (1950) (01-02-2012)“…Natural IgM Abs are the constitutively secreted products of B1 cells (CD5(+) in mice and CD20(+)CD27(+)CD43(+)CD70(-) in humans) that have important and…”
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Circulating Normal IgG as Stimulator of Regulatory T Cells: Lessons from Intravenous Immunoglobulin
Published in Trends in immunology (01-11-2017)“…Intravenous immunoglobulin (IVIG), a pooled normal IgG formulation prepared from thousands of healthy donors’ plasma, is extensively used for the immunotherapy…”
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Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation‐dependent mechanism
Published in European journal of immunology (01-01-2019)“…Intravenous immunoglobuin (IVIG) exerts protective effects in experimental allergic bronchopulmonary aspergillosis (ABPA) via a sialylation‐dependent…”
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Molecular and immunological biomarkers to predict IVIg response
Published in Trends in molecular medicine (01-03-2015)“…Some patients with autoimmune and inflammatory diseases treated with intravenous immunoglobulin G (IVIg) as a first line therapy are refractory. Identification…”
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Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease
Published in Drug discovery today (01-11-2016)“…•Kawasaki disease (KD) is an acute childhood disease with coronary artery lesions.•Endothelial cell injury is mediated by T cells and cytokines (TNF-α and…”
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Aspergillus fumigatus Cell Wall α-(1,3)-Glucan Stimulates Regulatory T-Cell Polarization by Inducing PD-L1 Expression on Human Dendritic Cells
Published in The Journal of infectious diseases (05-12-2017)“…α-(1,3)-Glucan polysaccharide of Aspergillus fumigatus induces human dendritic cell maturation and stimulates regulatory T-cell (Treg) responses by the…”
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Boolean analysis of the transcriptomic data to identify novel biomarkers of IVIG response
Published in Autoimmunity reviews (01-07-2021)“…Intravenous immunoglobulin (IVIG) is used to treat several autoimmune and inflammatory diseases, but some patients are refractory to IVIG and require…”
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Intravenous immunoglobulin immunotherapy for coronavirus disease‐19 (COVID‐19)
Published in Clinical & translational immunology (2020)“…Intravenous immunoglobulin (IVIG), a pooled normal IgG from several thousand healthy donors and one of the commonly used immunotherapeutic molecules for the…”
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Intravenous immunoglobulin expands regulatory T cells via induction of cyclooxygenase-2–dependent prostaglandin E2 in human dendritic cells
Published in Blood (22-08-2013)“…CD4+CD25+FoxP3+ regulatory T cells (Tregs) play a critical role in the maintenance of immune tolerance. Intravenous immunoglobulin (IVIg), a therapeutic…”
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Vaccine‐induced immune thrombotic thrombocytopenia: Consider IVIG batch in the treatment
Published in Journal of thrombosis and haemostasis (01-07-2021)Get full text
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Intravenous immunoglobulin therapy in rheumatic diseases
Published in Nature reviews. Rheumatology (01-06-2011)“…The use of intravenous immunoglobulin for rheumatic diseases is explored in the Review, with a focus on the conditions for which its use is best indicated,…”
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