Chronic Exposure to Dim Light at Night or Irregular Lighting Conditions Impact Circadian Behavior, Motor Coordination, and Neuronal Morphology

Mistimed exposure to light has been demonstrated to negatively affect multiple aspects of physiology and behavior. Here we analyzed the effects of chronic exposure to abnormal lighting conditions in mice. We exposed mice for 1 year to either: a standard light/dark cycle, a "light-pollution"...

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Bibliographic Details
Published in:	Frontiers in neuroscience Vol. 16; p. 855154
Main Authors:	Delorme, Tara C, Srikanta, Shashank B, Fisk, Angus S, Cloutier, Marie-Ève, Sato, Miho, Pothecary, Carina A, Merz, Chantal, Foster, Russell G, Brown, Steven A, Peirson, Stuart N, Cermakian, Nicolas, Banks, Gareth T
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Research Foundation 13-04-2022 Frontiers Media S.A
Subjects:	Aging Behavior bioluminescence Body temperature Chronic exposure circadian disruption Circadian rhythm Circadian rhythms dendritic morphology Dendritic spines Experiments Gene expression Laboratories Light light at night Lighting Mental disorders Mental health Morphology Neuroscience Phenotypes Physiology Retina dendritic morphology light at night aging behavior bioluminescence circadian disruption
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Summary:	Mistimed exposure to light has been demonstrated to negatively affect multiple aspects of physiology and behavior. Here we analyzed the effects of chronic exposure to abnormal lighting conditions in mice. We exposed mice for 1 year to either: a standard light/dark cycle, a "light-pollution" condition in which low levels of light were present in the dark phase of the circadian cycle (dim light at night, DLAN), or altered light cycles in which the length of the weekday and weekend light phase differed by 6 h ("social jetlag"). Mice exhibited several circadian activity phenotypes, as well as changes in motor function, associated particularly with the DLAN condition. Our data suggest that these phenotypes might be due to changes outside the core clock. Dendritic spine changes in other brain regions raise the possibility that these phenotypes are mediated by changes in neuronal coordination outside of the clock. Given the prevalence of artificial light exposure in the modern world, further work is required to establish whether these negative effects are observed in humans as well.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Alun Thomas Lloyd Hughes, Liverpool John Moores University, United Kingdom This article was submitted to Sleep and Circadian Rhythms, a section of the journal Frontiers in Neuroscience Reviewed by: Gurprit Lall, University of Kent, United Kingdom; Laura K. Fonken, University of Texas at Austin, United States; Michael Antle, University of Calgary, Canada These authors share first authorship
ISSN:	1662-4548 1662-453X 1662-453X
DOI:	10.3389/fnins.2022.855154