Search Results - "Srikant, C B"

Induction of wild‐type p53, Bax, and acidic endonuclease during somatostatin‐signaled apoptosis in MCF‐7 human breast cancer cells by Sharma, Kamal, Srikant, Coimbatore B.

“…Somatostatin (SST) analogs inhibit tumor cell growth by exerting direct anti‐proliferative effects with cytostatic (growth arrest) or cytotoxic (apoptosis)…”
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Somatostatin Receptors by Patel, Yogesh C, Srikant, Coimbatore B

“…The diverse biological effects of somatostatin (SRIF) are mediated by a family of G protein-coupled receptors (termed sst) that are encoded by five nonallelic…”
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Morphological correlates of the differential responses of muscles to vecuronium by Ibebunjo, C, Srikant, C B, Donati, F

“…We have noted previously that duration of vecuronium block correlated with fibre size in six muscle groups in the goat. Electrophysiological considerations…”
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Interdependent regulation of intracellular acidification and SHP-1 in apoptosis by THANGARAJU, M, SHARMA, K, LIU, D, SHEN, S.-H, SRIKANT, C. B

“…The G protein-coupled receptor agonist somatostatin (SST)-induces apoptosis in MCF-7 human breast cancer cells. This is associated with induction of wild-type…”
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Cell Cycle Dependent Induction of Apoptosis by Somatostatin Analog SMS 201-995 in AtT-20 Mouse Pituitary Cells by Srikant, C.B.

“…Somatostatin (SS) and its analogs exert direct antiproliferative effects in a variety of tumor cells not only by inhibiting the mitogenic signalling of growth…”
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Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation by Patel, Y C, Greenwood, M, Kent, G, Panetta, R, Srikant, C B

“…The rodent SSTR2 mRNA has been reported to be alternatively spliced to generate long (SSTR2A) and short (SSTR2B) receptor isoforms which differ in sequence at…”
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Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28 by Panetta, R, Greenwood, M T, Warszynska, A, Demchyshyn, L L, Day, R, Niznik, H B, Srikant, C B, Patel, Y C

“…Using a combination of polymerase chain reaction and genomic library screening we have cloned a human gene for a subtype of the somatostatin (SST) receptor…”
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Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype by PATEL, Y. C, PANETTA, R, ESCHER, E, GREENWOOD, M, SRIKANT, C. B

“…The pattern of expression of somatostatin receptor (SSTR) genes and gene products in AtT-20 cells was characterized in an attempt to explain the SST-28 binding…”
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Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells by Srikant, C B, Shen, S H

“…Somatostatin (SST) analogs exert direct antiproliferative actions in pancreatic, pituitary, and mammary tumor cells in vitro. SST receptor (SSTR)-mediated…”
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Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20 by Demchyshyn, L L, Srikant, C B, Sunahara, R K, Kent, G, Seeman, P, Van Tol, H H, Panetta, R, Patel, Y C, Niznik, H B

“…Based on pharmacological, biochemical, and molecular criteria, multiple somatostatin receptor (SSTR) subtypes selective for somatostatin (SST)-14 and -28 have…”
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The somatostatin receptor family by Patel, Y C, Greenwood, M T, Panetta, R, Demchyshyn, L, Niznik, H, Srikant, C B

“…The diverse biological effects of somatostatin (SST) are mediated through a family of G protein coupled receptors of which 5 members have been recently…”
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Somatostatin Receptors: Identification and Characterization in Rat Brain Membranes by Srikant, Coimbatore B., Patel, Yogesh C.

“…We have identified and characterized specific receptors for tetradecapeptide somatostatin (SRIF; somatotropin release-inhibiting factor) in rat brain using…”
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Receptor binding of somatostatin-28 is tissue specific by Srikant, C. B, Patel, Y. C

“…The authors suggest here that the greater potency of S-28 for inhibiting growth hormone secretion is because it binds to pituitary S-14 receptors with 3.2-fold…”
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Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3 by Sharma, K, Patel, Y C, Srikant, C B

“…Somatostatin (SST) exerts direct antiproliferative effects in tumor cells, triggering either growth arrest or apoptosis. The cellular actions of SST are…”
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Relationship between receptor binding and biopotency of somatostatin-14 and somatostatin-28 in mouse pituitary tumor cells by Srikant, C B, Heisler, S

“…Somatostatin-14 (S-14) acts via specific receptors to inhibit basal as well as hormone- and forskolin-stimulated ACTH secretion in tumor cells (AtT-20/D16-16)…”
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A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides by Corness, Jacquie D., Demchyshyn, Lidia L., Seeman, Philip, Van Tol, Hubert H.M., Srikant, Coimbatore B., Kent, Gillian, Patel, Yogesh C., Niznik, Hyman B.

“…We report here on the cloning of a human intronless gene encoding a member of the G-protein linked somatostatin (SST) receptor subfamily, termed SSTR3. Based…”
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Duration of succinylcholine and vecuronium blockade but not potency correlates with the ratio of endplate size to fibre size in seven muscles in the goat by IBEBUNJO, C, SRIKANT, C. B, DONATI, F

“…Muscles differ in their response to neuromuscular relaxants. This study investigated whether (1) the relative responses of muscles is inverted between…”
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Evidence for multiple protein constituents of the somatostatin receptor in pituitary tumor cells: affinity cross-linking and molecular characterization by Murthy, K K, Srikant, C B, Patel, Y C

“…Previous studies have shown that somatostatin receptors on AtT-20 and GH3 pituitary tumor cells show relative preference for binding somatostatin-28 (S-28) and…”
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Mechanism of action of somatostatin: an overview of receptor function and studies of the molecular characterization and purification of somatostatin receptor proteins by Patel, Y C, Murthy, K K, Escher, E E, Banville, D, Spiess, J, Srikant, C B

“…To determine whether somatostatin receptor subtypes arise from molecular heterogeneity of the receptor protein, we have cross-linked the putative receptor in…”
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All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase by Patel, Y C, Greenwood, M T, Warszynska, A, Panetta, R, Srikant, C B

“…Recent reports have suggested that only some of the cloned somatostatin receptors (SSTRs) are coupled to adenylyl cyclase. These studies have used both stable…”
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