Search Results - "Sridhar, Sushmita"

Seeing the bigger picture by Zellmer, Caroline, Tran, Tuan Anh, Sridhar, Sushmita

“…This month’s Genome Watch highlights the need for improved phenotypic approaches to complement the power of genomics…”
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Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study by Meredith, Luke W, Hamilton, William L, Warne, Ben, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Curran, Martin D, Parmar, Surendra, Caller, Laura G, Caddy, Sarah L, Khokhar, Fahad A, Yakovleva, Anna, Hall, Grant, Feltwell, Theresa, Forrest, Sally, Sridhar, Sushmita, Weekes, Michael P, Baker, Stephen, Brown, Nicholas, Moore, Elinor, Popay, Ashley, Roddick, Iain, Reacher, Mark, Gouliouris, Theodore, Peacock, Sharon J, Dougan, Gordon, Török, M Estée, Goodfellow, Ian

“…The burden and influence of health-care associated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unknown. We aimed to examine the…”
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Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission by Rivett, Lucy, Sridhar, Sushmita, Sparkes, Dominic, Routledge, Matthew, Jones, Nick K, Forrest, Sally, Young, Jamie, Pereira-Dias, Joana, Hamilton, William L, Ferris, Mark, Torok, M Estee, Meredith, Luke, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Samworth, Richard J, Bradley, John R, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Matheson, Nicholas J, Wright, Giles, Goodfellow, Ian G, Baker, Stephen, Weekes, Michael P

“…Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening…”
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Ventilator-associated pneumonia in critically ill patients with COVID-19 by Maes, Mailis, Higginson, Ellen, Pereira-Dias, Joana, Curran, Martin D, Parmar, Surendra, Khokhar, Fahad, Cuchet-Lourenço, Delphine, Lux, Janine, Sharma-Hajela, Sapna, Ravenhill, Benjamin, Hamed, Islam, Heales, Laura, Mahroof, Razeen, Soderholm, Amelia, Forrest, Sally, Sridhar, Sushmita, Brown, Nicholas M, Baker, Stephen, Navapurkar, Vilas, Dougan, Gordon, Bartholdson Scott, Josefin, Conway Morris, Andrew

“…Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients…”
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Inherent Variability of Growth Media Impacts the Ability of Salmonella Typhimurium to Interact with Host Cells by Sridhar, Sushmita, Steele-Mortimer, Olivia

“…Efficient invasion of non-phagocytic cells, such as intestinal epithelial cells, by Salmonella Typhimurium is dependent on the Salmonella Pathogenicity Island…”
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An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation by Van Puyvelde, Sandra, Pickard, Derek, Vandelannoote, Koen, Heinz, Eva, Barbé, Barbara, de Block, Tessa, Clare, Simon, Coomber, Eve L., Harcourt, Katherine, Sridhar, Sushmita, Lees, Emily A., Wheeler, Nicole E., Klemm, Elizabeth J., Kuijpers, Laura, Mbuyi Kalonji, Lisette, Phoba, Marie-France, Falay, Dadi, Ngbonda, Dauly, Lunguya, Octavie, Jacobs, Jan, Dougan, Gordon, Deborggraeve, Stijn

“…Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal…”
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Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in isolates of Salmonella Typhimurium by Tran, Tuan-Anh, Sridhar, Sushmita, Reece, Stephen T., Lunguya, Octavie, Jacobs, Jan, Van Puyvelde, Sandra, Marks, Florian, Dougan, Gordon, Thomson, Nicholas R., Nguyen, Binh T., Bao, Pham The, Baker, Stephen

“…Antimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Current susceptibility testing approaches limit our…”
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A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa by Van Puyvelde, Sandra, de Block, Tessa, Sridhar, Sushmita, Bawn, Matt, Kingsley, Robert A., Ingelbeen, Brecht, Beale, Mathew A., Barbé, Barbara, Jeon, Hyon Jin, Mbuyi-Kalonji, Lisette, Phoba, Marie-France, Falay, Dadi, Martiny, Delphine, Vandenberg, Olivier, Affolabi, Dissou, Rutanga, Jean Pierre, Ceyssens, Pieter-Jan, Mattheus, Wesley, Cuypers, Wim L., van der Sande, Marianne A. B., Park, Se Eun, Kariuki, Simon, Otieno, Kephas, Lusingu, John P. A., Mbwana, Joyce R., Adjei, Samuel, Sarfo, Anima, Agyei, Seth O., Asante, Kwaku P., Otieno, Walter, Otieno, Lucas, Tahita, Marc C., Lompo, Palpouguini, Hoffman, Irving F., Mvalo, Tisungane, Msefula, Chisomo, Hassan-Hanga, Fatimah, Obaro, Stephen, Mackenzie, Grant, Deborggraeve, Stijn, Feasey, Nicholas, Marks, Florian, MacLennan, Calman A., Thomson, Nicholas R., Jacobs, Jan, Dougan, Gordon, Kariuki, Samuel, Lunguya, Octavie

“…Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in…”
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Inhibitory Concentrations of Ciprofloxacin Induce an Adaptive Response Promoting the Intracellular Survival of Salmonella enterica Serovar Typhimurium by Sridhar, Sushmita, Forrest, Sally, Pickard, Derek, Cormie, Claire, Lees, Emily A, Thomson, Nicholas R, Dougan, Gordon, Baker, Stephen

“…Antimicrobial resistance (AMR) is a pressing global health crisis, which has been fueled by the sustained use of certain classes of antimicrobials, including…”
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High-Content Imaging to Phenotype Antimicrobial Effects on Individual Bacteria at Scale by Sridhar, Sushmita, Forrest, Sally, Warne, Ben, Maes, Mailis, Baker, Stephen, Dougan, Gordon, Bartholdson Scott, Josefin

“…High-content imaging (HCI) is a technique for screening multiple cells in high resolution to detect subtle morphological and phenotypic variation. The method…”
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Multiplexed real-time PCR for the detection and differentiation of Klebsiella pneumoniae O-antigen serotypes by Slater, Damien, Hutt Vater, Kian, Sridhar, Sushmita, Hwang, Wontae, Bielawski, Derek, Turbett, Sarah E, LaRocque, Regina C, Harris, Jason B

“…has emerged as a global health threat due to its role in the spread of antimicrobial resistance and because it is a frequent cause of hospital-acquired…”
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Correction to: Ventilator-associated pneumonia in critically ill patients with COVID-19 by Maes, Mailis, Higginson, Ellen, Pereira-Dias, Joana, Curran, Martin D, Parmar, Surendra, Khokhar, Fahad, Cuchet-Lourenço, Delphine, Lux, Janine, Sharma-Hajela, Sapna, Ravenhill, Benjamin, Hamed, Islam, Heales, Laura, Mahroof, Razeen, Soderholm, Amelia, Forrest, Sally, Sridhar, Sushmita, Brown, Nicholas M, Baker, Stephen, Navapurkar, Vilas, Dougan, Gordon, Scott, Josefn Bartholdson, Morris, Andrew Conway

“…An amendment to this paper has been published and can be accessed via the original article…”
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Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer by Clarke, Nicole, Biscocho, Jewison, Kwei, Kevin A, Davidson, Jean M, Sridhar, Sushmita, Gong, Xue, Pollack, Jonathan R

“…NKX2-1, encoding a homeobox transcription factor, is amplified in approximately 15% of non-small cell lung cancers (NSCLC), where it is thought to drive cancer…”
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A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities by Sridhar, Sushmita, Forrest, Sally, Kean, Iain, Young, Jamie, Bartholdson Scott, Josefin, Maes, Mailis, Pereira-Dias, Joana, Parmar, Surendra, Routledge, Matthew, Sparkes, Dominic, Rivett, Lucy, Dougan, Gordon, Weekes, Michael, Curran, Martin, Goodfellow, Ian, Baker, Stephen

“…The COVID-19 pandemic is expanding at an unprecedented rate. As a result, diagnostic services are stretched to their limit, and there is a clear need for the…”
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Antimicrobial-resistant bacteria in international travelers by Sridhar, Sushmita, Turbett, Sarah E., Harris, Jason B., LaRocque, Regina C.

“…Antimicrobial resistance (AMR) in bacteria poses a major risk to global public health, with many factors contributing to the observed increase in AMR…”
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Antimicrobial-resistant bacteria in international travelers by Sridhar, Sushmita, Turbett, Sarah E., Harris, Jason B., LaRocque, Regina C.

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Clinical and Genomic Characterization of a Cohort of Patients With Klebsiella pneumoniae Bloodstream Infection by Roach, David J, Sridhar, Sushmita, Oliver, Elizabeth, Rao, Sowmya R, Slater, Damien M, Hwang, Wontae, Hutt Vater, Kian, Dinesh, Anupama, Qadri, Firdausi, Chisti, Mohammod J, Pierce, Virginia M, Turbett, Sarah E, Bhattacharyya, Roby P, Worby, Colin J, Earl, Ashlee M, LaRocque, Regina C, Harris, Jason B

“…The clinical and microbial factors associated with Klebsiella pneumoniae bloodstream infections (BSIs) are not well characterized. Prior studies have focused…”
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Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections by Illingworth, Christopher Jr, Hamilton, William L, Warne, Ben, Routledge, Matthew, Popay, Ashley, Jackson, Chris, Fieldman, Tom, Meredith, Luke W, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Caller, Laura G, Caddy, Sarah L, Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin D, Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K, Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Ferris, Mark, Gkrania-Klotsas, Effrossyni, Brown, Nicholas M, Weekes, Michael P, Baker, Stephen, Peacock, Sharon J, Goodfellow, Ian G, Gouliouris, Theodore, de Angelis, Daniela, Török, M Estée

“…SARS-CoV-2 is notable both for its rapid spread, and for the heterogeneity of its patterns of transmission, with multiple published incidences of…”
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Targeting NLRP3 and Staphylococcal pore‐forming toxin receptors in human‐induced pluripotent stem cell‐derived macrophages by Chow, Seong H., Deo, Pankaj, Yeung, Amy T. Y., Kostoulias, Xenia P., Jeon, Yusun, Gao, Mei‐Ling, Seidi, Azadeh, Olivier, Françios Alwyn Benson, Sridhar, Sushmita, Nethercott, Cara, Cameron, David, Robertson, Avril A. B., Robert, Remy, Mackay, Charles R., Traven, Ana, Jin, Zi‐Bing, Hale, Christine, Dougan, Gordon, Peleg, Anton Y., Naderer, Thomas

“…Staphylococcus aureus causes necrotizing pneumonia by secreting toxins such as leukocidins that target front‐line immune cells. The mechanism by which…”
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Salmonella Meningitis Associated with Monocyte Infiltration in Mice by Bauler, Timothy J, Starr, Tregei, Nagy, Toni A, Sridhar, Sushmita, Scott, Dana, Winkler, Clayton W, Steele-Mortimer, Olivia, Detweiler, Corrella S, Peterson, Karin E

“…In the current study, we examined the ability of Salmonella enterica serovar Typhimurium to infect the central nervous system and cause meningitis following…”
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