Search Results - "Sreenivasan, Varun"

Comparative single-cell analysis of the adult heart and coronary vasculature by Balachandran, Saranya, Pozojevic, Jelena, Sreenivasan, Varun K. A., Spielmann, Malte

“…The structure and function of the circulatory system, including the heart, have undergone substantial changes with the vertebrate evolution. Although the basic…”
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Intrinsic Efficacy of Opioid Ligands and Its Importance for Apparent Bias, Operational Analysis, and Therapeutic Window by Gillis, Alexander, Sreenivasan, Varun, Christie, Macdonald J.

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Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development by Sreenivasan, Varun K A, Dore, Riccardo, Resch, Julia, Maier, Julia, Dietrich, Carola, Henck, Jana, Balachandran, Saranya, Mittag, Jens, Spielmann, Malte

“…Thyroid hormone and its receptor TRα1 play an important role in brain development. Several animal models have been used to investigate this function, including…”
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Nature of the Amyloid-β Monomer and the Monomer-Oligomer Equilibrium by Nag, Suman, Sarkar, Bidyut, Bandyopadhyay, Arkarup, Sahoo, Bankanidhi, Sreenivasan, Varun K.A., Kombrabail, Mamata, Muralidharan, Chandrakesan, Maiti, Sudipta

“…The monomer to oligomer transition initiates the aggregation and pathogenic transformation of Alzheimer amyloid-β (Aβ) peptide. However, the monomeric state of…”
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Quantitative imaging of single upconversion nanoparticles in biological tissue by Nadort, Annemarie, Sreenivasan, Varun K A, Song, Zhen, Grebenik, Ekaterina A, Nechaev, Andrei V, Semchishen, Vladimir A, Panchenko, Vladislav Y, Zvyagin, Andrei V

“…The unique luminescent properties of new-generation synthetic nanomaterials, upconversion nanoparticles (UCNPs), enabled high-contrast optical biomedical…”
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Pyramidal cell regulation of interneuron survival sculpts cortical networks by Wong, Fong Kuan, Bercsenyi, Kinga, Sreenivasan, Varun, Portalés, Adrián, Fernández-Otero, Marian, Marín, Oscar

“…Complex neuronal circuitries such as those found in the mammalian cerebral cortex have evolved as balanced networks of excitatory and inhibitory neurons…”
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In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation by Raoufi-Rad, Newsha, McRobb, Lucinda S, Lee, Vivienne S, Bervini, David, Grace, Michael, Ukath, Jaysree, Mchattan, Joshua, Sreenivasan, Varun K A, Duong, T T Hong, Zhao, Zhenjun, Stoodley, Marcus A

“…Focussed radiosurgery may provide a means of inducing molecular changes on the luminal surface of diseased endothelium to allow targeted delivery of novel…”
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STIGMA: Single-cell tissue-specific gene prioritization using machine learning by Balachandran, Saranya, Prada-Medina, Cesar A., Mensah, Martin A., Glaser, Juliane, Kakar, Naseebullah, Nagel, Inga, Pozojevic, Jelena, Audain, Enrique, Hitz, Marc-Phillip, Kircher, Martin, Sreenivasan, Varun K.A., Spielmann, Malte

“…Clinical exome and genome sequencing have revolutionized the understanding of human disease genetics. Yet many genes remain functionally uncharacterized,…”
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STIGMA: Single-cell tissue-specific gene prioritization using machine learning by Balachandran, Saranya, Prada-Medina, Cesar A., Mensah, Martin A., Glaser, Juliane, Kakar, Naseebullah, Nagel, Inga, Pozojevic, Jelena, Audain, Enrique, Hitz, Marc-Phillip, Kircher, Martin, Sreenivasan, Varun K.A., Spielmann, Malte

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Electromechanics and Volume Dynamics in Nonexcitable Tissue Cells by Yellin, Florence, Li, Yizeng, Sreenivasan, Varun K.A., Farrell, Brenda, Johny, Manu B., Yue, David, Sun, Sean X.

“…Cell volume regulation is fundamentally important in phenomena such as cell growth, proliferation, tissue homeostasis, and embryogenesis. How the cell size is…”
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Human Prestin: A Candidate PE1 Protein Lacking Stringent Mass Spectrometric Evidence? by Mohamedali, Abidali, Ahn, Seong Beom, Sreenivasan, Varun K. A, Ranganathan, Shoba, Baker, Mark S

“…The evidence that any protein exists in the Human Proteome Project (HPP; protein evidence 1 or PE1) has revolved primarily (although not exclusively) around…”
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Luminescent nanoparticles and their applications in the life sciences by Sreenivasan, Varun K A, Zvyagin, Andrei V, Goldys, Ewa M

“…Nanoparticles have recently emerged as an important group of materials used in numerous disciplines within the life sciences, ranging from basic biophysical…”
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Single-cell sequencing: promises and challenges for human genetics by Sreenivasan, Varun K. A., Henck, Jana, Spielmann, Malte

“…Over the last decade, single-cell sequencing has transformed many fields. It has enabled the unbiased molecular phenotyping of even whole organisms with…”
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Single-cell, whole-embryo phenotyping of mammalian developmental disorders by Huang, Xingfan, Henck, Jana, Qiu, Chengxiang, Sreenivasan, Varun K. A., Balachandran, Saranya, Amarie, Oana V., Hrabě de Angelis, Martin, Behncke, Rose Yinghan, Chan, Wing-Lee, Despang, Alexandra, Dickel, Diane E., Duran, Madeleine, Feuchtinger, Annette, Fuchs, Helmut, Gailus-Durner, Valerie, Haag, Natja, Hägerling, Rene, Hansmeier, Nils, Hennig, Friederike, Marshall, Cooper, Rajderkar, Sudha, Ringel, Alessa, Robson, Michael, Saunders, Lauren M., da Silva-Buttkus, Patricia, Spielmann, Nadine, Srivatsan, Sanjay R., Ulferts, Sascha, Wittler, Lars, Zhu, Yiwen, Kalscheuer, Vera M., Ibrahim, Daniel M., Kurth, Ingo, Kornak, Uwe, Visel, Axel, Pennacchio, Len A., Beier, David R., Trapnell, Cole, Cao, Junyue, Shendure, Jay, Spielmann, Malte

“…Mouse models are a critical tool for studying human diseases, particularly developmental disorders 1 . However, conventional approaches for phenotyping may…”
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Position effects at the FGF8 locus are associated with femoral hypoplasia by Socha, Magdalena, Sowińska-Seidler, Anna, Melo, Uirá Souto, Kragesteen, Bjørt K., Franke, Martin, Heinrich, Verena, Schöpflin, Robert, Nagel, Inga, Gruchy, Nicolas, Mundlos, Stefan, Sreenivasan, Varun K.A., López, Cristina, Vingron, Martin, Bukowska-Olech, Ewelina, Spielmann, Malte, Jamsheer, Aleksander

“…Copy-number variations (CNVs) are a common cause of congenital limb malformations and are interpreted primarily on the basis of their effect on gene dosage…”
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Force Measurements for Cancer Cells by Rajasekharan, Vivek, Sreenivasan, Varun K A, Farrell, Brenda

“…During cytoskeleton remodeling, cancer cells generate force at the plasma membrane that originates from chemical motors (e.g., actin). This force (pN) and its…”
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Motor Control by Sensory Cortex by Matyas, Ferenc, Sreenivasan, Varun, Marbach, Fred, Wacongne, Catherine, Barsy, Boglarka, Mateo, Celine, Aronoff, Rachel, Petersen, Carl C.H

“…Classical studies of mammalian movement control define a prominent role for the primary motor cortex. Investigating the mouse whisker system, we found an…”
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Feasibility study of the optical imaging of a breast cancer lesion labeled with upconversion nanoparticle biocomplexes by Grebenik, Ekaterina A, Nadort, Annemarie, Generalova, Alla N, Nechaev, Andrei V, Sreenivasan, Varun K. A, Khaydukov, Evgeny V, Semchishen, Vladimir A, Popov, Alexey P, Sokolov, Viktor I, Akhmanov, Aleksandr S, Zubov, Vitali P, Klinov, Dmitry V, Panchenko, Vladislav Y, Deyev, Sergey M, Zvyagin, Andrei V

“…Innovative luminescent nanomaterials, termed upconversion nanoparticles (UCNPs), have demonstrated considerable promise as molecular probes for high-contrast…”
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Transcriptional Alterations in X-Linked Dystonia-Parkinsonism Caused by the SVA Retrotransposon by Pozojevic, Jelena, Algodon, Shela Marie, Cruz, Joseph Neos, Trinh, Joanne, Brüggemann, Norbert, Laß, Joshua, Grütz, Karen, Schaake, Susen, Tse, Ronnie, Yumiceba, Veronica, Kruse, Nathalie, Schulz, Kristin, Sreenivasan, Varun K A, Rosales, Raymond L, Jamora, Roland Dominic G, Diesta, Cid Czarina E, Matschke, Jakob, Glatzel, Markus, Seibler, Philip, Händler, Kristian, Rakovic, Aleksandar, Kirchner, Henriette, Spielmann, Malte, Kaiser, Frank J, Klein, Christine, Westenberger, Ana

“…X-linked dystonia-parkinsonism (XDP) is a severe neurodegenerative disorder that manifests as adult-onset dystonia combined with parkinsonism. A SINE-VNTR-Alu…”
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Development of Bright and Biocompatible Nanoruby and Its Application to Background-Free Time-Gated Imaging of G‑Protein-Coupled Receptors by Sreenivasan, Varun K. A., Wan Razali, Wan Aizuddin, Zhang, Kai, Pillai, Rashmi R., Saini, Avishkar, Denkova, Denitza, Santiago, Marina, Brown, Hannah, Thompson, Jeremy, Connor, Mark, Goldys, Ewa M., Zvyagin, Andrei V.

“…At the forefront of developing fluorescent probes for biological imaging applications are enhancements aimed at increasing their brightness, contrast, and…”
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