Search Results - "Sreenilayam, Gopeekrishnan"

Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction by Tyagi, Vikas, Sreenilayam, Gopeekrishnan, Bajaj, Priyanka, Tinoco, Antonio, Fasan, Rudi

“…The first example of a biocatalytic [2,3]‐sigmatropic rearrangement reaction involving allylic sulfides and diazo reagents (Doyle–Kirmse reaction) is reported…”
Get full text

Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts by Sreenilayam, Gopeekrishnan, Moore, Eric J., Steck, Viktoria, Fasan, Rudi

“…Engineered myoglobins have recently emerged as promising scaffolds for catalyzing carbene‐mediated transformations. In this work, we investigated the effect of…”
Get full text

Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates by Sreenilayam, Gopeekrishnan, Fasan, Rudi

“…Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of α-diazo esters into the N-H bond of arylamines,…”
Get more information

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity by Bajaj, Priyanka, Sreenilayam, Gopeekrishnan, Tyagi, Vikas, Fasan, Rudi

“…Engineered hemoproteins have recently emerged as promising systems for promoting asymmetric cyclopropanations, but variants featuring predictable,…”
Get full text

Stereoselective Olefin Cyclopropanation under Aerobic Conditions with an Artificial Enzyme Incorporating an Iron-Chlorin e6 Cofactor by Sreenilayam, Gopeekrishnan, Moore, Eric J, Steck, Viktoria, Fasan, Rudi

“…Myoglobin has recently emerged as a promising biocatalyst for catalyzing carbene-mediated cyclopropanation, a synthetically valuable transformation not found…”
Get full text

Enantioselective Synthesis of α‑Trifluoromethyl Amines via Biocatalytic N–H Bond Insertion with Acceptor-Acceptor Carbene Donors by Nam, Donggeon, Tinoco, Antonio, Shen, Zhuofan, Adukure, Ronald D, Sreenilayam, Gopeekrishnan, Khare, Sagar D, Fasan, Rudi

“…The biocatalytic toolbox has recently been expanded to include enzyme-catalyzed carbene transfer reactions not occurring in Nature. Herein, we report the…”
Get full text

Unified Strategy for 1,5,9- and 1,5,7-Triols via Configuration-Encoded 1,5-Polyol Synthesis: Enantioselective Preparation of γ‑Sulfonyl-α-silyloxyaldehydes and Iterative Julia–Kocienski Coupling by Friedrich, Ryan M, Sreenilayam, Gopeekrishnan, Hackbarth, Jacob, Friestad, Gregory K

“…Diverse classes of natural products contain chiral 1,5-polyols, within which may be stereochemical triads of 1,5,9- and 1,5,7-triols. Biological activities…”
Get full text

Biocatalytic synthesis of allylic and allenyl sulfides via a myoglobin-catalyzed Doyle-Kirmse reaction by Tyagi, Vikas, Sreenilayam, Gopeekrishnan, Bajaj, Priyanka, Tinoco, Antonio, Fasan, Rudi

“…The first example of a biocatalytic [ 2 , 3 ]-sigmatropic rearrangement reaction involving allylic sulfides and diazo reagents (Doyle-Kirmse reaction) is…”
Get full text

Versatile Configuration-Encoded Strategy for Rapid Synthesis of 1,5-Polyol Stereoisomers by Friestad, Gregory K, Sreenilayam, Gopeekrishnan

“…The isolated stereogenic centers of 1,5-polyol-containing natural products present challenges to synthesis and structure determination. To address this…”
Get full text

1,5-Polyols: Challenging motifs for configurational assignment and synthesis by Friestad, Gregory K., Sreenilayam, Gopeekrishnan

“…Despite the well-established methods for stereochemical assignments and synthesis of 1,3-diols, the corresponding 1,5-diols and -polyols present specific…”
Get full text

Preparation of enol ester epoxides and their ring-opening to α-silyloxyaldehydes by Friestad, Gregory K., Sreenilayam, Gopeekrishnan, Cannistra, Joseph C., Slominski, Luke M.

“…The Z-selective ruthenium-catalyzed addition of aromatic carboxylic acids to alkynes was followed by dioxirane epoxidation to furnish enol ester epoxides with…”
Get full text

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity by Bajaj, Priyanka, Sreenilayam, Gopeekrishnan, Tyagi, Vikas, Fasan, Rudi

“…Engineered hemoproteins have recently emerged as promising systems for promoting asymmetric cyclopropanations, but variants featuring predictable,…”
Get full text

Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction by Tyagi, Vikas, Sreenilayam, Gopeekrishnan, Bajaj, Priyanka, Tinoco, Antonio, Fasan, Rudi

“…The first example of a biocatalytic [2,3]‐sigmatropic rearrangement reaction involving allylic sulfides and diazo reagents (Doyle–Kirmse reaction) is reported…”
Get full text

Preparation of enol ester epoxides and their ring-opening to [alpha]-silyloxyaldehydes by Friestad, Gregory K, Sreenilayam, Gopeekrishnan, Cannistra, Joseph C, Slominski, Luke M

“…The Z-selective ruthenium-catalyzed addition of aromatic carboxylic acids to alkynes was followed by dioxirane epoxidation to furnish enol ester epoxides with…”
Get full text

Asymmetric 1,5-polyol synthesis: A concise configuration-encoded approach by Sreenilayam, Gopeekrishnan

“…Chiral 1,5-polyol motifs are found in many biologically active, diverse classes of natural products and pharmaceutical drug candidates. Some notable examples…”
Get full text

Asymmetric 1,5-polyol synthesis: A concise configuration-encoded approach by Sreenilayam, Gopeekrishnan

“…Chiral 1,5-polyol motifs are found in many biologically active, diverse classes of natural products and pharmaceutical drug candidates. Some notable examples…”
Get full text