Search Results - "Sravya, Palavalasa"

Differential gene expression in peritumoral brain zone of glioblastoma: role of SERPINA3 in promoting invasion, stemness and radioresistance of glioma cells and association with poor patient prognosis and recurrence by Nimbalkar, Vidya P., Kruthika, Banavathy S., Sravya, Palavalasa, Rao, Shilpa, Sugur, Harsha S., Verma, Brijesh Kumar, Chickabasaviah, Yasha T., Arivazhagan, Arimappamagan, Kondaiah, Paturu, Santosh, Vani

“…Purpose Glioblastoma (GBM) is a highly invasive tumor. Despite advances in treatment modalities, tumor recurrence is common, seen mainly in the peritumoral…”
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L1CAM Immunopositivity in Anaplastic Supratentorial Ependymomas: Correlation With Clinical and Histological Parameters by Chavali, Pooja, Rao, Shilpa, Palavalasa, Sravya, Bevinahalli, Nandeesh, Muthane, Yasha T. C., Sadashiva, Nishanth, Santosh, Vani

“…Supratentorial ependymomas (ST EPNs) are molecularly characterized, of which the RELA fusion positive tumors are the most common and aggressive subgroup…”
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Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma by Peterson, Erik R, Sajjakulnukit, Peter, Scott, Andrew J, Heaslip, Caleb, Andren, Anthony, Wilder-Romans, Kari, Zhou, Weihua, Palavalasa, Sravya, Korimerla, Navyateja, Lin, Angelica, O'Brien, Alexandra, Kothari, Ayesha, Zhao, Zitong, Zhang, Li, Morgan, Meredith A, Venneti, Sriram, Koschmann, Carl, Jabado, Nada, Lyssiotis, Costas A, Castro, Maria G, Wahl, Daniel R

“…Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver…”
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Granular cells in oligodendroglioma suggest a neoplastic change rather than a reactive phenomenon: case report with molecular characterisation by Rao, Shilpa, Sravya, Palavalasa, Chandran, Chitra, Saini, Jitender, Somanna, Sampath, Santosh, Vani

“…Oligodendrogliomas are diffuse gliomas characterised by IDH mutation and 1p/19q co-deletion. Classical oligodendrocytes, minigemistocytes, gliofibrillary…”
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Prognostic Factors and Outcomes in World Health Organization Grade 1 and Grade 2 Intracranial Meningiomas—5-Year Institutional Experience by Nadeem, Mohammed, Goyal-Honavar, Abhijit, Sravya, Palavalasa, Beniwal, Manish, Santosh, Vani, Dwarakanath, Srinivas

“…Meningiomas are the most frequent primary intracranial tumor. While histological grade and grade of excision are established predictors of recurrence, the…”
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DNAR-08. THY1 MEDIATES TREATMENT RESISTANCE IN GLIOBLASTOMA THROUGH RAPID REPAIR OF DNA DAMAGE by Basha Syed, Safiulla, Tripathy, Arushi, Ravikumar, Visweswaran, Awadia, Sahezeel, Palavalasa, Sravya, Huang, Dah-Luen, Rao, Arvind, Wahl, Daniel R, Rehemtulla, Alnawaz, Al-Holou, Wajd N

“…Glioblastoma (GBM) is a uniformly lethal primary intracranial neoplasm that inevitably recurs despite treatment by DNA damaging agents radiation (RT) and…”
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Glioma, glutamate (SLC7A11) and seizures-a commentary by Santosh, Vani, Sravya, Palavalasa

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IMMU-04. G-AMINOBUTYRIC ACID DRIVES GLIOBLASTOMA IN FEMALES IN AN IMMUNE-DEPENDENT MANNER by Pathak, Asmita, Palavalasa, Sravya, Ciervo, Erika, Van Den Knott, Maxon Berg, Susic, Nikola, Shah, Khushi Hemendra, Colon, Bruno, Chin, Diana, Zhou, Yadi, Cheng, Feixiong, Lyssiotis, Costas, Watson, Dionysios C, Wahl, Daniel, Ceccarelli, Michele, Shah, Ashish, Lathia, Justin D, Bayik, Defne

“…Communication with a neuronal network and accumulation of myeloid-derived suppressive cells (MDSCs) support GBM growth and therapeutic resistance. GBM…”
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TMIC-25. MICROGLIA IN THE GLIOBLASTOMA MICROENVIRONMENT SECRETE ACETYLATED AMINO ACIDS WHICH ASSIST IN THE REPAIR OF RADIATION INDUCED DNA DAMAGE by Palavalasa, Sravya, Freeman, Jack, Singer, Ava, Gokul, Aditri, Baker, Emily, Scott, Andrew, Wilder-Romans, Kari, Shankar, Sunita, Ravikumar, Visweswaran, Andren, Anthony, Wong, Harrison, Sajjakulnikit, Peter, Bhaduri, Sagnik, Zhou, Weihua, Lyssiotis, Costas, Rao, Arvind, Al-holou, Wajd, Wahl, Daniel

“…Rapid repair of DNA damage mediates genotoxic therapy resistance and poor prognosis in glioblastoma (GBM). The GBM tumor microenvironment (TME) is…”
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DNAR-02. MICROGLIA IN THE GLIOBLASTOMA MICROENVIRONMENT ASSIST REPAIR OF RADIATION INDUCED DNA DAMAGE IN A CONTACT INDEPENDENT MANNER by Palavalasa, Sravya, Singer, Ava, Scott, Andrew, Wilder-Romans, Kari, Shankar, Sunita, Ravikumar, Visweswaran, Bhadury, Sagnik, Andren, Anthony, Sajjakulnukit, Peter, Zhou, Weihua, Lyssiotis, Costas A, Rao, Arvind, Al-holou, Wajd, Wahl, Daniel R

“…Rapid repair of DNA damage mediates genotoxic therapy resistance and poor prognosis in glioblastoma (GBM). The GBM tumor microenvironment (TME) is…”
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TMET-03. REPROGRAMMING OF GLIOBLASTOMA GLUCOSE METABOLISM FUELS TUMOR GROWTH by Scott, Andrew J, Mittal, Anjali, Al-Holou, Wajd, Palavalasa, Sravya, Meghdadi, Baharan, O'Brien, Alexandra, Zhou, Weihua, Yang, Annabel, Zhao, Zitong, Lin, Angelica, Tarnal, Vijay, Lyssiotis, Costas, Nagrath, Deepak, Wahl, Daniel R

“…Metabolic adaptation can promote oncogenic phenotypes in glioblastoma (GBM), but the metabolic pathways utilized by GBM and how they differ from the pathways…”
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Chitinase 3-Like 2: A Novel Biomarker Expressed in Peritumoral Brain Zone of Glioblastoma is associated With tumor recurrence and Poor Patient Prognosis by Nimbalkar, Vidya P, Kruthika, Banavathy S, Sravya, Palavalasa, Rao, Shilpa, Sugur, Harsha S, Chickabasaviah, Yasha T, Somanna, Sampath, Arivazhagan, Arimappamagan, Kondaiah, Paturu, Santosh, Vani

“…Objectives: We aimed to evaluate the expression pattern of chitinase 3-like 2 (CHI3L2) in the tumor core and peritumoral brain zone (PBZ) of newly diagnosed…”
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Chitinase 3-Like 2 by Nimbalkar, Vidya P, Kruthika, Banavathy S, Sravya, Palavalasa, Rao, Shilpa, Sugur, Harsha S, Chickabasaviah, Yasha T, Somanna, Sampath, Arivazhagan, Arimappamagan, Kondaiah, Paturu, Santosh, Vani

“…Abstract Objectives We aimed to evaluate the expression pattern of chitinase 3-like 2 (CHI3L2) in the tumor core and peritumoral brain zone (PBZ) of newly…”
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Abstract 1789: Machine learning-based method to analyze metabolic fluxes of patient tumors by Meghdadi, Baharan, Mittal, Anjali, Scott, Andrew J., Palavalasa, Sravya, Wahl, Daniel R., Nagrath, Deepak

“…Personalized oncology must overcome the complex challenge of distinct cancer phenotypes in each patient, formed in part in response to unique metabolic…”
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TMET-19. REWIRING OF CORTICAL GLUCOSE METABOLISM FUELS HUMAN BRAIN CANCER GROWTH by Scott, Andrew, Mittal, Anjali, Meghdadi, Baharan, Palavalasa, Sravya, Achreja, Abhinav, O’Brien, Alexandra, Kothari, Ayesha, Zhou, Weihua, Xu, Jie, Lin, Angelica, Wilder-Romans, Kari, Edwards, Donna, Wu, Zhe, Feng, Jiane, Andren, Anthony, Zhang, Li, Tarnal, Vijay, Redic, Kimberly, Qi, Nathan, Fischer, Joshua, Yang, Ethan, Regan, Michael, Stopka, Sylwia, Baquer, Gerard, Lawrence, Theodore, Venneti, Sriram, Agar, Nathalie, Lyssiotis, Costas, Al-Holou, Wajd, Nagrath, Deepak, Wahl, Daniel

“…The brain avidly consumes glucose to fuel neurophysiology. Cancers of the brain, such as glioblastoma (GBM), lose aspects of normal biology and gain the…”
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TMET-27. MACHINE LEARNING-BASED IDENTIFICATION OF METABOLIC FLUXES IN PATIENT BRAIN TUMORS by Meghdadi, Baharan, Mittal, Anjali, Scott, Andrew, Liang, Ningning, Palavalasa, Sravya, Achreja, Abhinav, Kothari, Alexandra O’Brien Ayesha, Zhou, Weihua, Xu, Jie, Lin, Angelica, Wilder-Romans, Kari, Edwards, Donna, Wu, Zhe, Feng, Jiane, Andren, Anthony, Zhang, Li, Tarnal, Vijay, Redic, Kimberly, Qi, Nathan, Lawrence, Theodore, Lyssiotis, Costas, Al-Holou, Wajd, Wahl, Daniel, Nagrath, Deepak

“…Personalized oncology aims to match effective treatments for individual cancer patients based on the biology of an individual tumor. This approach is not…”
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TMET-28. RECIPROCAL LINKS BETWEEN METHIONINE METABOLISM, DNA REPAIR AND THERAPY RESISTANCE IN GLIOBLASTOMA by Korimerla, Navyateja, Wilder-Romans, Kari, Xu, Jie, Haq, Isra, Zhou, Weihua, Kalev, Peter, Qi, Nathan, Evans, Charles, Kachman, Maureen, Zhao, Zitong, Lin, Angelica, Scott, Andrew J, O’Brien, Alexandra, Kothari, Ayesha, Palavalasa, Sravya, Peterson, Erik, Hyer, Marc L, Marjon, Katya, Lyssiotis, Costas A, Sleger, Taryn, Wahl, Daniel R

“…Glioblastoma (GBM) is uniformly lethal due to profound treatment resistance. Altered cellular metabolism is a key mediator of GBM treatment resistance. Uptake…”
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IRX1 is a novel gene, overexpressed in high-grade IDH-mutant astrocytomas by Sugur, Harsha S., Rao, Shilpa, Sravya, Palavalasa, Athul Menon, K., Arivazhagan, Arimappamagan, Mehta, Bhupesh, Santosh, Vani

“…IDH-mutant astrocytomas include CNS WHO grade 2 (A2), grade 3 (A3) and grade 4 (A4), of which A3 and A4 are high-grade. A3 has a heterogenous clinical outcome…”
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CBMT-24. MITOCHONDRIAL DNA CONTENT IN GLIOBLASTOMA AND ITS CLINICAL SIGNIFICANCE by Sravya, Palavalasa, Rao, Shilpa, Nimbalkar, Vidya, Kanuri, Nandaki, Banavathy, Kruthika, Arimappamagan, Arivazhagan, Somanna, Sampath, Santosh, Vani

“…Abstract Evidence of altered mitochondrial DNA (mtDNA) content in several malignancies has surfaced in recent years. However, in glioblastoma, this aspect…”
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Low mitochondrial DNA copy number is associated with poor prognosis and treatment resistance in glioblastoma by Sravya, Palavalasa, Nimbalkar, Vidya Prasad, Kanuri, Nandaki Nag, Sugur, Harsha, Verma, Brijesh Kumar, Kundu, Paramita, Rao, Shilpa, Uday Krishna, A.S., Somanna, Sampath, Kondaiah, Paturu, Arivazhagan, Arimappamagan, Santosh, Vani

“…•Mitochondrial DNA (mtDNA) copy number is a prognostic marker in glioblastoma (GBM).•Low mtDNA copy number in GBM is associated with poor prognosis.•Recurrent…”
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