Search Results - "Srai, Surjit K.S."

The Effect of Iron Status on Risk of Coronary Artery Disease: A Mendelian Randomization Study—Brief Report by Gill, Dipender, Del Greco M, Fabiola, Walker, Ann P, Srai, Surjit K.S, Laffan, Michael A, Minelli, Cosetta

“…OBJECTIVE—Iron status is a modifiable trait that has been implicated in cardiovascular disease. This study uses the Mendelian randomization technique to…”
Get full text

Divalent metal-dependent regulation of hepcidin expression by MTF-1 by Balesaria, Sara, Ramesh, Bala, McArdle, Harry, Bayele, Henry K., Srai, Surjit K.S.

“…Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia…”
Get full text

Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron by BALESARIA, Sara, HANIF, Rumeza, SALAMA, Mohamed F, RAJA, Kishor, BAYELE, Henry K, MCARDLE, Harry, SRAI, Surjit K. S

“…Iron metabolism during pregnancy maintains fetal iron levels at the expense of the mother. The mechanism behind this regulation is still not clear despite…”
Get full text

The trafficking of metal ion transporters of the Zrt‐ and Irt‐like protein family by Bowers, Katherine, Srai, Surjit K. S.

“…Metal ion transporters of the Zrt‐ and Irt‐like protein (ZIP, or SLC39A) family transport zinc, iron, manganese and/or cadmium across cellular membranes and…”
Get full text

Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption by Bayele, Henry K., Balesaria, Sara, Srai, Surjit K.S.

“…Hepcidin is a liver-derived antimicrobial peptide that regulates iron absorption and is also an integral part of the acute phase response. In a previous…”
Get full text

The role of iron in the skin and cutaneous wound healing by Wright, Josephine A, Richards, Toby, Srai, Surjit K S

“…In this review article we discuss current knowledge about iron in the skin and the cutaneous wound healing process. Iron plays a key role in both oxidative…”
Get full text

Role of Dietary Flavonoids in Iron Homeostasis by Lesjak, Marija, K S Srai, Surjit

“…Balancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no…”
Get full text

Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro by Lesjak, Marija, Hoque, Rukshana, Balesaria, Sara, Skinner, Vernon, Debnam, Edward S, Srai, Surjit K S, Sharp, Paul A

“…Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the…”
Get full text

Diet‐induced iron deficiency in rats impacts small intestinal calcium and phosphate absorption by Asowata, Evans O., Olusanya, Oluwatobi, Abaakil, Kaoutar, Chichger, Havovi, Srai, Surjit K. S., Unwin, Robert J., Marks, Joanne

“…Aims Recent reports suggest that iron deficiency impacts both intestinal calcium and phosphate absorption, although the exact transport pathways and intestinal…”
Get full text

Can Polyphenols Inhibit Ferroptosis? by Lesjak, Marija, Simin, Nataša, Srai, Surjit K S

“…Polyphenols, a diverse group of naturally occurring molecules commonly found in higher plants, have been heavily investigated over the last two decades due to…”
Get full text

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis-A Systematic Review by Živanović, Nemanja, Lesjak, Marija, Simin, Nataša, Srai, Surjit K S

“…Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as…”
Get full text

Cis and trans regulation of hepcidin expression by upstream stimulatory factor by Bayele, Henry K., McArdle, Harry, Srai, Surjit K.S.

“…Hepcidin is the presumed negative regulator of systemic iron levels; its expression is induced in iron overload, infection, and inflammation, and by cytokines,…”
Get full text

Effect of hepcidin on intestinal iron absorption in mice by Laftah, Abas H., Ramesh, Bala, Simpson, Robert J., Solanky, Nita, Bahram, Seiamak, Schümann, Klaus, Debnam, Edward S., Srai, Surjit K.S.

“…The effect of the putative iron regulatory peptide hepcidin on iron absorption was investigated in mice. Hepcidin peptide was synthesized and injected into…”
Get full text

strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia by Dłużniewska, Joanna, Sarnowska, Anna, Beręsewicz, Małgorzata, Johnson, Ian, Srai, Surjit K. S, Ramesh, Bala, Goldspink, Geoffrey, Górecki, Dariusz C, Zabłocka, Barbara

“…ABSTRACTThe ischemic stroke is the third leading cause of death in developed countries. The C‐terminal peptide of mechano‐growth factor (MGF), an alternatively…”
Get full text

Regulatory variation in hepcidin expression as a heritable quantitative trait by Bayele, Henry K., Srai, Surjit K.S.

“…Genetic variation underlies phenotypic diversity and complex quantitative traits including heritable diseases. We hypothesized that such variation may underlie…”
Get full text

Mobilisation of recently absorbed 59Fe in ex vivo perfused rat duodena and the influence of iron status and subsequently absorbed chelators by Ettle, Thomas, Elsenhans, Bernd, Windisch, Wilhelm, Srai, Surjit K.S., Schümann, Klaus

“…To investigate the effect of subsequently absorbed metal chelators on recently absorbed 59Fe, duodenal segments from iron-deficient and iron-adequate rats were…”
Get full text

Structural and cellular adaptation of duodenal iron uptake in rats maintained on an iron-deficient diet by Smith, M. W., Debnam, E. S., Dashwood, M. R., Srai, S.K.S.

“…Iron deficiency induced in rats maintained on a commercial diet with a low iron content has been used to investigate adaptive mechanisms that enhance duodenal…”
Get full text

Secondary structure analysis of the putative membrane-associated domains of the inward rectifier K+ channel ROMK1 by Brazier, S P, Ramesh, B, Haris, P I, Lee, D C, Srai, S K

“…The inward rectifier K+ channels contain two putative membrane-spanning domains per subunit (M1, M2) and a 'pore' (P) region, which is similar to the H5 domain…”
Get full text

Synthetic putative transmembrane region of minimal potassium channel protein (minK) adopts an alpha-helical conformation in phospholipid membranes by Mercer, E A, Abbott, G W, Brazier, S P, Ramesh, B, Haris, P I, Srai, S K

“…Minimal potassium channel protein (minK) is a potassium channel protein consisting of 130 amino acids, possessing just one putative transmembrane domain. In…”
Get full text

Mechanisms involved in increased iron uptake across rat duodenal brush-border membrane during hypoxia by O'Riordan, D K, Debnam, E S, Sharp, P A, Simpson, R J, Taylor, E M, Srai, S K

“…1. Chronic hypoxia enhances intestinal iron transport but the cellular processes involved are poorly understood. In order to assess the effects of 3 days of…”
Get full text