Search Results - "Squire, J.A"

First application of the Automated QUantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: A correlative study of NCIC CTG OV.16 by Weberpals, J.I, Amin, M.S, Chen, B.E, Tu, D, Spaans, J.N, Squire, J.A, Eisenhauer, E.A, Virk, S, Ma, D, Duciaume, M, Hoskins, P, LeBrun, D.P

“…Abstract Background Platinum resistance is a dominant cause of poor outcomes in advanced ovarian cancer (OC). A mechanism of platinum resistance is the…”
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Genomic alterations detected by comparative genomic hybridization in ovarian endometriomas by Veiga-Castelli, L C, Silva, J C Rosa E, Meola, J, Ferriani, R A, Yoshimoto, M, Santos, S A, Squire, J A, Martelli, L

“…Endometriosis is a complex and multifactorial disease. Chromosomal imbalance screening in endometriotic tissue can be used to detect hot-spot regions in the…”
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MP-17.17: FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome by Yoshimoto, M, Cunha, I.W, Coudry, R.A, Fonseca, F.P, Torres, C.H, Soares, F.A, Squire, J.A

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High-resolution cDNA microarray CGH mapping of genomic imbalances in osteosarcoma using formalin-fixed paraffin-embedded tissue by Zielenska, M, Marrano, P, Thorner, P, Pei, J, Beheshti, B, Ho, M, Bayani, J, Liu, Y, Sun, B C, Squire, J A, Hao, X-S

“…Formalin-fixed paraffin embedded (FFPE) tumor tissue provides an opportunity to perform retrospective genomic studies of tumors in which chromosomal imbalances…”
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PTEN deletion detected using dual-color FISH in esophageal squamous cell carcinoma correlates with poor prognosis by Sato-Kuwabara, Y, Yoshimoto, M, Neves, J.I, Squire, J.A, Soares, F.A

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Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer by Sadikovic, B, Al-Romaih, K, Squire, J A, Zielenska, M

“…Both genetic and epigenetic changes contribute to development of human cancer. Oncogenomics has primarily focused on understanding the genetic basis of…”
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The Role of RUNX2 in Osteosarcoma Oncogenesis by van Wijnen, A. J., Zielenska, Maria, Stein, Gary S., Squire, Jeremy A., Martin, Jeff W.

“…Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited…”
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Breast cancer 1 (BRCA1) protein expression as a prognostic marker in sporadic epithelial ovarian carcinoma: an NCIC CTG OV.16 correlative study by Weberpals, J.I., Tu, D., Squire, J.A., Amin, M.S., Islam, S., Pelletier, L.B., O'Brien, A.M., Hoskins, P.J., Eisenhauer, E.A.

“…Breast cancer 1 (BRCA1) protein inactivation in sporadic ovarian carcinoma (OC) is common and low BRCA1 expression is linked with platinum sensitivity. The…”
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Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH by Selvarajah, S, Yoshimoto, M, Ludkovski, O, Park, P C, Bayani, J, Thorner, P, Maire, G, Squire, J A, Zielenska, M

“…Osteosarcoma (OS) is characterized by an unstable karyotype which typically has a heterogeneous pattern of complex chromosomal abnormalities. High-resolution…”
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Topographical analysis of telomere length and correlation with genomic instability in whole mount prostatectomies by Joshua, A.M., Shen, E., Yoshimoto, M., Marrano, P., Zielenska, M., Evans, A.J., Van der Kwast, T., Squire, J.A.

“…BACKGROUND Many critical events in prostatic carcinogenesis appear to relate to the emergence of genomic instability. Characteristic genomic abnormalities such…”
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Prostatic preneoplasia and beyond by Joshua, A.M., Evans, A., Van der Kwast, T., Zielenska, M., Meeker, A.K., Chinnaiyan, A., Squire, J.A.

“…Prostate cancer is a heterogeneous neoplasm both with regard to its development, molecular abnormalities and clinical course. For example, in the United…”
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Correlating breakage-fusion-bridge events with the overall chromosomal instability and in vitro karyotype evolution in prostate cancer by Vukovic, B, Beheshti, B, Park, P, Lim, G, Bayani, J, Zielenska, M, Squire, J A

“…Chromosomal instability (CIN) is thought to underlie the generation of chromosomal changes and genomic heterogeneity during prostatic tumorigenesis. The…”
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Integrated cytogenetic and high-resolution array CGH analysis of genomic alterations associated with MYCN amplification by Pandita, A, Bayani, J, Paderova, J, Marrano, P, Graham, C, Barrett, M, Prasad, M, Zielenska, M, Squire, J A

“…Amplification of oncogenes and closely linked flanking genes is common in some types of cancer and can be associated with complex chromosome rearrangements…”
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Analysis of segmental duplications, mouse genome synteny and recurrent cancer-associated amplicons in human chromosome 6p21-p12 by Martin, J W, Yoshimoto, M, Ludkovski, O, Thorner, P S, Zielenska, M, Squire, J A, Nuin, P A S

“…It has been proposed that regions of microhomology in the human genome could facilitate genomic rearrangements, copy number transitions, and rapid genomic…”
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The use of cytogenetics in understanding ovarian cancer by Bernardini, M., Weberpals, J., Squire, J.A.

“…The future of cancer research is no longer limited to epidemiological data and clinical management, but rather encompasses a new dimension of understanding,…”
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Use of whole genome amplification and comparative genomic hybridisation to detect chromosomal copy number alterations in cell line material and tumour tissue by Hughes, S, Lim, G, Beheshti, B, Bayani, J, Marrano, P, Huang, A, Squire, J A

“…We have established that whole genome amplification (WGA), in conjunction with genomic DNA array comparative genomic hybridisation (gaCGH) allows for the…”
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Assignment of the human prostaglandin-endoperoxide synthase 2 (PTGS2) gene to 1q25 by fluorescence in situ hybridization by Tay, A, Squire, J A, Goldberg, H, Skorecki, K

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Mechanisms of loss of heterozygosity in retinoblastoma by Zhu, X, Dunn, J M, Goddard, A D, Squire, J A, Becker, A, Phillips, R A, Gallie, B L

“…Retinoblastoma (RB) tumors arise when both alleles of the RB1 gene are inactivated by two mutational events (M1 and M2). M1 can be an initial germline or…”
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Comparative genomic hybridization analysis of Y79 and FISH mapping indicate the amplified human mitochondrial ATP synthase alpha-subunit gene (ATP5A) maps to chromosome 18q12-->q21 by Godbout, R, Pandita, A, Beatty, B, Bie, W, Squire, J A

“…The four mitochondrial ATP synthase alpha-subunit (ATP5A) genes map to chromosomes 2, 9, 16, and 18. In this study we have refined the localization of two of…”
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Chromosomal instability in osteosarcoma and its association with centrosome abnormalities by Al-Romaih, K, Bayani, J, Vorobyova, J, Karaskova, J, Park, P.C, Zielenska, M, Squire, J.A

“…The mechanism that generates the extreme aneuploidy that characterizes osteosarcoma (OS) is poorly understood. In this study, interphase fluorescence in situ…”
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