Search Results - "Squadrito, Francesco"

Oxidative Stress: Harms and Benefits for Human Health by Bitto, Alessandra, Altavilla, Domenica, Arcoraci, Vincenzo, Mannino, Federica, Pallio, Giovanni, Cucinotta, Mariapaola, Irrera, Natasha, Pizzino, Gabriele, Squadrito, Francesco

“…Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the…”
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The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury by Irrera, Natasha, Russo, Massimo, Pallio, Giovanni, Bitto, Alessandra, Mannino, Federica, Minutoli, Letteria, Altavilla, Domenica, Squadrito, Francesco

“…Traumatic brain injury (TBI) represents an important problem of global health. The damage related to TBI is first due to the direct injury and then to a…”
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ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury by Pisani, Antonina, Trichilo, Vincenzo, Bruschetta, Daniele, Micali, Antonio, Altavilla, Domenica, Crea, Giovanni, Bitto, Alessandra, Arcoraci, Vincenzo, Marini, Herbert, Irrera, Natasha, Rinaldi, Mariagrazia, Puzzolo, Domenico, Minutoli, Letteria, Squadrito, Francesco

“…Ischemia and reperfusion (I/R) causes a reduction in arterial blood supply to tissues, followed by the restoration of perfusion and consequent reoxygenation…”
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Cadmium, Organ Toxicity and Therapeutic Approaches: A Review on Brain, Kidney and Testis Damage by Rinaldi, Mariagrazia, Micali, Antonio, Marini, Herbert, Adamo, Elena Bianca, Puzzolo, Domenico, Pisani, Antonina, Trichilo, Vincenzo, Altavilla, Domenica, Squadrito, Francesco, Minutoli, Letteria

“…Cadmium (Cd) is a heavy metal particularly hazardous for human health, as it is highly diffused and, therefore, a ubiquitous environmental toxicant. In fact,…”
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Pharmacological Activity and Clinical Use of PDRN by Squadrito, Francesco, Bitto, Alessandra, Irrera, Natasha, Pizzino, Gabriele, Pallio, Giovanni, Minutoli, Letteria, Altavilla, Domenica

“…PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic…”
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Anti-oxidant and anti-inflammatory effects of ellagic and punicic acid in an in vitro model of cardiac fibrosis by Mannino, Federica, Imbesi, Chiara, Bitto, Alessandra, Minutoli, Letteria, Squadrito, Francesco, D’Angelo, Tommaso, Booz, Christian, Pallio, Giovanni, Irrera, Natasha

“…Cardiac fibrosis is a pathological process characterized by an excessive deposition of extracellular matrix (ECM) and an increased production of fibrillar…”
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Attention Deficit Hyperactivity Disorder (ADHD) and Polyphenols: A Systematic Review by Turiaco, Fabrizio, Cullotta, Chiara, Mannino, Federica, Bruno, Antonio, Squadrito, Francesco, Pallio, Giovanni, Irrera, Natasha

“…Polyphenols are natural compounds also contained in daily consumed foods that show their efficacy in different clinical fields. Both pre-clinical and clinical…”
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Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments by Custurone, Paolo, Di Bartolomeo, Luca, Irrera, Natasha, Borgia, Francesco, Altavilla, Domenica, Bitto, Alessandra, Pallio, Giovanni, Squadrito, Francesco, Vaccaro, Mario

“…Vitiligo is a chronic autoimmune dermatosis of which the pathogenesis remains scarcely known. A wide variety of clinical studies have been proposed to…”
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Wnt Signaling Pathways: From Inflammation to Non-Melanoma Skin Cancers by Di Bartolomeo, Luca, Vaccaro, Federico, Irrera, Natasha, Borgia, Francesco, Li Pomi, Federica, Squadrito, Francesco, Vaccaro, Mario

“…Canonical and non-canonical Wnt signaling pathways are involved in cell differentiation and homeostasis, but also in tumorigenesis. In fact, an exaggerated…”
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Reduction of oxidative stress blunts the NLRP3 inflammatory cascade in LPS stimulated human gingival fibroblasts and oral mucosal epithelial cells by Picciolo, Giacomo, Mannino, Federica, Irrera, Natasha, Minutoli, Letteria, Altavilla, Domenica, Vaccaro, Mario, Oteri, Giacomo, Squadrito, Francesco, Pallio, Giovanni

“…The therapeutic armamentarium for the treatment of oral mucositis is very poor. Catechin and baicalin are two natural flavonoids that have been individually…”
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Retraction Note: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis by Bitto, Alessandra, Minutoli, Letteria, David, Antonio, Irrera, Natasha, Rinaldi, Mariagrazia, Venuti, Francesco S, Squadrito, Francesco, Altavilla, Domenica

“…Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Biglycan Involvement in Heart Fibrosis: Modulation of Adenosine 2A Receptor Improves Damage in Immortalized Cardiac Fibroblasts by Scuruchi, Michele, Mannino, Federica, Imbesi, Chiara, Pallio, Giovanni, Vermiglio, Giovanna, Bagnato, Gianluca, Minutoli, Letteria, Bitto, Alessandra, Squadrito, Francesco, Irrera, Natasha

“…Cardiac fibrosis is a common pathological feature of different cardiovascular diseases, characterized by the aberrant deposition of extracellular matrix (ECM)…”
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ROS and Brain Gliomas: An Overview of Potential and Innovative Therapeutic Strategies by Rinaldi, Mariagrazia, Caffo, Maria, Minutoli, Letteria, Marini, Herbert, Abbritti, Rosaria Viola, Squadrito, Francesco, Trichilo, Vincenzo, Valenti, Andrea, Barresi, Valeria, Altavilla, Domenica, Passalacqua, Marcello, Caruso, Gerardo

“…Reactive oxygen species (ROS) represent reactive products belonging to the partial reduction of oxygen. It has been reported that ROS are involved in different…”
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NLRP3 Inflammasome: A New Pharmacological Target for Reducing Testicular Damage Associated with Varicocele by Antonuccio, Pietro, Micali, Antonio Girolamo, Romeo, Carmelo, Freni, Jose, Vermiglio, Giovanna, Puzzolo, Domenico, Squadrito, Francesco, Irrera, Natasha, Marini, Herbert R, Rana, Rosa Alba, Pallio, Giovanni, Minutoli, Letteria

“…Many bioactive natural compounds are being increasingly used for therapeutics and nutraceutical applications to counteract male infertility, particularly…”
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Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice by Pizzino, Gabriele, Irrera, Natasha, Galfo, Federica, Pallio, Giovanni, Mannino, Federica, D'amore, Angelica, Pellegrino, Enrica, Ieni, Antonio, Russo, Giuseppina T, Calapai, Marco, Altavilla, Domenica, Squadrito, Francesco, Bitto, Alessandra

“…Background and Purpose Diabetic patients with non‐healing ulcers have a reduced expression of VEGF. Genetically diabetic mice have an altered expression…”
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Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial by Squadrito, Francesco, Marini, Herbert, Bitto, Alessandra, Altavilla, Domenica, Polito, Francesca, Adamo, Elena Bianca, D'Anna, Rosario, Arcoraci, Vincenzo, Burnett, Bruce P, Minutoli, Letteria, Di Benedetto, Antonino, Di Vieste, Giacoma, Cucinotta, Domenico, de Gregorio, Cesare, Russo, Silvia, Corrado, Francesco, Saitta, Antonino, Irace, Concetta, Corrao, Salvatore, Licata, Giuseppe

“…Context: This study was performed to evaluate the effects of genistein on metabolic and cardiovascular risk factors in Caucasian postmenopausal subjects with…”
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Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity by Mannino, Federica, Pallio, Giovanni, Imbesi, Chiara, Scarfone, Alessandro, Puzzolo, Domenico, Micali, Antonio, Freni, José, Squadrito, Francesco, Bitto, Alessandra, Minutoli, Letteria, Irrera, Natasha

“…Cadmium (Cd) is a transition heavy metal that is able to accumulate in the central nervous system and may induce cell death through reactive oxygen species…”
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β-Caryophyllene Reduces the Inflammatory Phenotype of Periodontal Cells by Targeting CB2 Receptors by Picciolo, Giacomo, Pallio, Giovanni, Altavilla, Domenica, Vaccaro, Mario, Oteri, Giacomo, Irrera, Natasha, Squadrito, Francesco

“…Human gingival fibroblasts (GF) and human oral mucosa epithelial cells (EC) with an inflammatory phenotype represent a valuable experimental paradigm to…”
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Off-Target Effects of P2Y12 Receptor Inhibitors: Focus on Early Myocardial Fibrosis Modulation by Lofrumento, Francesca, Irrera, Natasha, Licordari, Roberto, Perfetti, Silvia, Nasso, Enrica, Liotta, Paolo, Isgrò, Giovanni, Garcia-Ruiz, Victoria, Squadrito, Francesco, Carerj, Scipione, Di Bella, Gianluca, Micari, Antonio, Costa, Francesco

“…Several studies have demonstrated that, beyond their antithrombotic effects, P2Y12 receptor inhibitors may provide additional off-target effects through…”
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Effects of genistein aglycone in glucocorticoid induced osteoporosis: A randomized clinical trial in comparison with alendronate by Squadrito, Francesco, Imbalzano, Egidio, Rottura, Michelangelo, Arcoraci, Vincenzo, Pallio, Giovanni, Catalano, Antonino, Atteritano, Marco, Irrera, Natasha, Mannino, Federica, Squadrito, Giovanni, Vaccaro, Mario, Irrera, Pierangela, Pirrotta, Igor, Bitto, Alessandra

“…Glucocorticoid-induced osteoporosis (GIO) complicates the clinical management of patients subjected to long-term glucocorticoid use. This study explored the…”
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