Search Results - "Spyvee, M"

A novel antagonist of the prostaglandin E 2 EP 4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models by Chen, Q, Muramoto, K, Masaaki, N, Ding, Y, Yang, H, Mackey, M, Li, W, Inoue, Y, Ackermann, K, Shirota, H, Matsumoto, I, Spyvee, M, Schiller, S, Sumida, T, Gusovsky, F, Lamphier, M

“…Background and purpose:  Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17…”
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Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead by Du, H., Matsushima, T., Spyvee, M., Goto, M., Shirota, H., Gusovsky, F., Chiba, K., Kotake, M., Yoneda, N., Eguchi, Y., DiPietro, L., Harmange, J.-C., Gilbert, S., Li, X.-Y., Davis, H., Jiang, Y., Zhang, Z., Pelletier, R., Wong, N., Sakurai, H., Yang, H., Ito-Igarashi, H., Kimura, A., Kuboi, Y., Mizui, Y., Tanaka, I., Ikemori-Kawada, M., Kawakami, Y., Inoue, A., Kawai, T., Kishi, Y., Wang, Y.

“…With bioactivity-guided phenotype screenings, a potent anti-inflammatory compound f152A1 has been isolated, characterized and identified as the known natural…”
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A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models by Chen, Q, Muramoto, K, Masaaki, N, Ding, Y, Yang, H, Mackey, M, Li, W, Inoue, Y, Ackermann, K, Shirota, H, Matsumoto, I, Spyvee, M, Schiller, S, Sumida, T, Gusovsky, F, Lamphier, M

“…Background and purpose:  Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17…”
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Taxane diterpenes 5: Synthesis of the A- and C-rings: An unusual rearrangement of an N-hydroxyimino lactone by Magnus, Philip, Westwood, Nicholas, Spyvee, Mark, Frost, Christopher, Linnane, Patrick, Tavares, Francis, Lynch, Vince

“…Ring A of taxol was synthesized from the bromodiene 5 and acryloyl chloride to give 6, which was resolved by separation of diastereomers 7. Allylic oxidation…”
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A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models by Chen, Q, Muramoto, K, Masaaki, N, Ding, Y, Yang, H, Mackey, M, Li, W, Inoue, Y, Ackermann, K, Shirota, H, Matsumoto, I, Spyvee, M, Schiller, S, Sumida, T, Gusovsky, F, Lamphier, M

“…Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17 cells, which infiltrate and…”
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Concise synthesis of taxol a-ring components: Remote diastereoselective additions of alkenyl lithiums to aldehydes by Frost, Christopher, Linnane, Patrick, Magnus, Philip, Spyvee, Mark

“…The acid chloride 6 provides access to 7 (R,S and S,S) which upon bromine-lithium exchange undergoes remarkably highly diastereoselective additions to…”
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Toll-like receptor 2 antagonists. Part 1: Preliminary SAR investigation of novel synthetic phospholipids by Spyvee, Mark R., Zhang, Huiming, Hawkins, Lynn D., Chow, Jesse C.

“…Phospholipid compound 1 was discovered as a novel antagonist of toll-like receptor 2 signaling. Synthesis and biological properties are described for 1 and…”
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A biomimetic approach to the pyridone rings of the acromelic acids: A concise synthesis of acromelic acid A and an approach to acromelic acid B by Baldwin, Jack E., Fryer, Andrew M., Pritchard, Gareth J., Spyvee, Mark R., Whitehead, Roger C., Wood, Mark E.

“…The syntheses of acromelic acid A 1, allo-acromelic acid A 19 and an approach towards acromelic acid B 2 are described. Palladium (0) catalysed cross-coupling…”
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Concise syntheses of acromelic acid A and allo-acromelic acid A by Baldwin, Jack E., Fryer, Andrew M., Pritchard, Gareth J., Spyvee, Mark R., Whitehead, Roger C., Wood, Mark.E.

“…Acromelic acid A 1 and allo-acromelic acid A 12 were synthesised in a biomimetic fashion. An oxidative cleavage - recyclisation strategy was used to construct…”
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A biomimetic synthesis of stizolobinic acid by Baldwin, Jack E., Spyvee, Mark R., Whitehead, Roger C.

“…Stizolobinic acid ( 1) was synthesized in a biomimetic fashion from an analogue of l- DOPA via an oxidative cleavage reaction. An iron(III) catalysed oxidative…”
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Stereocontrol in the synthesis of kainoids by Baldwin, Jack E, Fryer, Andrew M, Spyvee, Mark R, Whitehead, Roger C, Wood, Mark E

“…A stereoselective synthesis of acromelic acid analogues is described in which the C-3 C-4 cis-relative stereochemistry is established by a hydroxyl directed…”
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