Search Results - "Spyer, Moira"

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study by Frampton, Dan, Rampling, Tommy, Cross, Aidan, Bailey, Heather, Heaney, Judith, Byott, Matthew, Scott, Rebecca, Sconza, Rebecca, Price, Joseph, Margaritis, Marios, Bergstrom, Malin, Spyer, Moira J, Miralhes, Patricia B, Grant, Paul, Kirk, Stuart, Valerio, Chris, Mangera, Zaheer, Prabhahar, Thaventhran, Moreno-Cuesta, Jeronimo, Arulkumaran, Nish, Singer, Mervyn, Shin, Gee Yen, Sanchez, Emilie, Paraskevopoulou, Stavroula M, Pillay, Deenan, McKendry, Rachel A, Mirfenderesky, Mariyam, Houlihan, Catherine F, Nastouli, Eleni

“…Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and…”
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Assessing spatiotemporal variability in SARS-CoV-2 infection risk for hospital workers using routinely-collected data by Wilson-Aggarwal, Jared K, Gotts, Nick, Arnold, Kellyn, Spyer, Moira J, Houlihan, Catherine F, Nastouli, Eleni, Manley, Ed

“…The COVID-19 pandemic has emphasised the need to rapidly assess infection risks for healthcare workers within the hospital environment. Using data from the…”
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Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial by Collinge, John, MD, Gorham, Michele, RN, Hudson, Fleur, BA, Kennedy, Angus, MD, Keogh, Geraldine, Pal, Suvankar, MRCP, Rossor, Martin, MD, Rudge, Peter, FRCP, Siddique, Durre, PhD, Spyer, Moira, PhD, Thomas, Dafydd, MD, Walker, Sarah, PhD, Webb, Tom, BSc, Wroe, Steve, MD, Darbyshire, Janet, FRCP

“…Summary Background The propagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases, requires post-translational…”
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Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial by Szubert, Alexander J, Prendergast, Andrew J, Spyer, Moira J, Musiime, Victor, Musoke, Philippa, Bwakura-Dangarembizi, Mutsa, Nahirya-Ntege, Patricia, Thomason, Margaret J, Ndashimye, Emmanuel, Nkanya, Immaculate, Senfuma, Oscar, Mudenge, Boniface, Klein, Nigel, Gibb, Diana M, Walker, A Sarah

“…Although WHO recommends viral load (VL) monitoring for those on antiretroviral therapy (ART), availability in low-income countries remains limited. We…”
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Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation by Bourke, Claire D, Gough, Ethan K, Pimundu, Godfrey, Shonhai, Annie, Berejena, Chipo, Terry, Louise, Baumard, Lucas, Choudhry, Naheed, Karmali, Yusuf, Bwakura-Dangarembizi, Mutsa, Musiime, Victor, Lutaakome, Joseph, Kekitiinwa, Adeodata, Mutasa, Kuda, Szubert, Alexander J, Spyer, Moira J, Deayton, Jane R, Glass, Magdalena, Geum, Hyun Min, Pardieu, Claire, Gibb, Diana M, Klein, Nigel, Edens, Thaddeus J, Walker, A Sarah, Manges, Amee R, Prendergast, Andrew J

“…Long-term cotrimoxazole prophylaxis reduces mortality and morbidity in HIV infection, but the mechanisms underlying these clinical benefits are unclear. Here,…”
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Factors influencing uptake of protective behaviours by healthcare workers in England during the COVID-19 pandemic: A theory-based mixed-methods study by Meyer, Carly, Crayton, Elise, Wright, Abigail, Spyer, Moira, Vora, Nina, Houlihan, Catherine, Walker, Naomi F, Nastouli, Eleni, Michie, Susan, Lorencatto, Fabiana

“…Hospital infection control policies protect patients and healthcare workers (HCWs) and limit the spread of pathogens, but adherence to COVID-19 guidance…”
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Antenatal Seroprevalence of Zika and Chikungunya Viruses, Kingston Metropolitan Area, Jamaica, 2017-2019 by Anzinger, Joshua J, Mears, Chadwic D, Ades, A E, Francis, Keisha, Phillips, Yakima, Leys, Ynolde E, Spyer, Moira J, Brown, David, de Filippis, Ana M Bispo, Nastouli, Eleni, Byrne, Thomas, Bailey, Heather, Palmer, Paulette, Bryan, Lenroy, Webster-Kerr, Karen, Giaquinto, Carlo, Thorne, Claire, Christie, Celia D C

“…To determine the extent of exposure to Zika virus (ZIKV) and chikungunya virus (CHIKV) in Jamaica, we collected serum from 584 pregnant women during 2017-2019…”
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A Randomized Trial of Prolonged Co-trimoxazole in HIV-Infected Children in Africa by Bwakura-Dangarembizi, Mutsawashe, Kendall, Lindsay, Bakeera-Kitaka, Sabrina, Nahirya-Ntege, Patricia, Keishanyu, Rosette, Nathoo, Kusum, Spyer, Moira J, Kekitiinwa, Adeodata, Lutaakome, Joseph, Mhute, Tawanda, Kasirye, Philip, Munderi, Paula, Musiime, Victor, Gibb, Diana M, Walker, A. Sarah, Prendergast, Andrew J

“…Co-trimoxazole is effective in preventing opportunistic infections in persons with advanced HIV infection. In this trial in southern Africa, prolonged…”
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Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self-reported antiretroviral therapy adherence by Fernández-Luis, Sheila, Lain, Maria Grazia, Serna-Pascual, Miquel, Domínguez-Rodríguez, Sara, Kuhn, Louise, Liberty, Afaaf, Barnabas, Shaun, Lopez-Varela, Elisa, Otwombe, Kennedy, Danaviah, Siva, Nastouli, Eleni, Palma, Paolo, Cotugno, Nicola, Spyer, Moira, Giannuzzi, Viviana, Giaquinto, Carlo, Violari, Avy, Cotton, Mark F, Nhampossa, Tacilta, Klein, Nigel, Ramsagar, Nastassja, van Rensburg, Anita Janse, Behuhuma, Osee, Vaz, Paula, Maiga, Almoustapha Issiaka, Oletto, Andrea, Naniche, Denise, Rossi, Paolo, Rojo, Pablo, Tagarro, Alfredo

“…The World Health Organization (WHO) risk assessment algorithm for vertical transmission of HIV (VT) assumes the availability of maternal viral load (VL) result…”
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The impact of viraemia on inflammatory biomarkers and CD4+ cell subpopulations in HIV-infected children in sub-Saharan Africa by Prendergast, Andrew J., Szubert, Alexander J., Pimundu, Godfrey, Berejena, Chipo, Pala, Pietro, Shonhai, Annie, Hunter, Patricia, Arrigoni, Francesca I.F., Musiime, Victor, Bwakura-Dangarembizi, Mutsa, Musoke, Philippa, Poulsom, Hannah, Kihembo, Macklyn, Munderi, Paula, Gibb, Diana M., Spyer, Moira J., Walker, A. Sarah, Klein, Nigel

“…To determine the impact of virological control on inflammation and cluster of differentiation 4 depletion among HIV-infected children initiating antiretroviral…”
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Nucleocapsid and spike antibody responses following virologically confirmed SARS-CoV-2 infection: an observational analysis in the Virus Watch community cohort by Navaratnam, Annalan M D, Shrotri, Madhumita, Nguyen, Vincent, Braithwaite, Isobel, Beale, Sarah, Byrne, Thomas E, Fong, Wing Lam Erica, Fragaszy, Ellen, Geismar, Cyril, Hoskins, Susan, Kovar, Jana, Patel, Parth, Yavlinsky, Alexei, Aryee, Anna, Rodger, Alison, Hayward, Andrew C, Aldridge, Robert W, Michie, Susan, Hardelid, Pia, Wijlaars, Linda, Nastouli, Eleni, Spyer, Moira, Killingley, Ben, Cox, Ingemar, Lampos, Vasileios, McKendry, Rachel A, Cheng, Tao, Liu, Yunzhe, Gibbs, Jo, Gilson, Richard, Johnson, Anne M

“…•If infection was confirmed by PCR, 80% of individuals were positive for nucleocapsid antibody.•The median nucleocapsid antibody level peaked between days 90…”
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Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance by Botha, Johannes C, Byott, Matthew, Spyer, Moira J, Grant, Paul R, Gärtner, Kathleen, Chen, Wilson X, Burton, James, Bamford, Alasdair, Waters, Laura J, Giaquinto, Carlo, Turkova, Anna, Vavro, Cindy L, Nastouli, Eleni

“…Modern HIV-1 treatment effectively suppresses viral amplification in people living with HIV. However, the persistence of HIV-1 DNA as proviruses integrated…”
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In Depth Viral Diversity Analysis in Atypical Neurological and Neonatal Chikungunya Infections in Rio de Janeiro, Brazil by Torres, Maria Celeste, Di Maio, Fatima, Brown, David, Spyer, Moira, Nastouli, Eleni, Brasil, Patrícia, Bispo de Filippis, Ana Maria

“…Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) transmitted by Aedes mosquitoes. The human infection usually manifests as a febrile and…”
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Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial by Gibb, Diana M, Kizito, Hilda, Russell, Elizabeth C, Chidziva, Ennie, Zalwango, Eva, Nalumenya, Ruth, Spyer, Moira, Tumukunde, Dinah, Nathoo, Kusum, Munderi, Paula, Kyomugisha, Hope, Hakim, James, Grosskurth, Heiner, Gilks, Charles F, Walker, A Sarah, Musoke, Phillipa

“…Few data have described long-term outcomes for infants born to HIV-infected African women taking antiretroviral therapy (ART) in pregnancy. This is…”
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Influence of IL-6 levels on patient survival in COVID-19 by Arulkumaran, Nishkantha, Snow, Timothy A.C., Kulkarni, Adarsh, Brealey, David, Rickman, Hannah M., Rees-Spear, Chloe, Spyer, Moira J., Heaney, Judith, Garr, Edmund, Williams, Bryan, Cherepanov, Peter, Kassiotis, George, Lunn, Michael P., Ambler, Gareth, Houlihan, Catherine, McCoy, Laura E., Nastouli, Eleni, Singer, Mervyn

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D3/Penta 21 clinical trial design: A randomised non-inferiority trial with nested drug licensing substudy to assess dolutegravir and lamivudine fixed dose formulations for the maintenance of virological suppression in children with HIV-1 infection, aged 2 to 15 years by Turkova, Anna, Chan, Man K., Kityo, Cissy, Kekitiinwa, Adeodata R., Musoke, Philippa, Violari, Avy, Variava, Ebrahim, Archary, Moherndran, Cressey, Tim R., Chalermpantmetagul, Suwalai, Sawasdichai, Kanokkorn, Ounchanum, Pradthana, Kanjanavanit, Suparat, Srirojana, Sakulrat, Srirompotong, Ussanee, Welch, Steven, Bamford, Alasdair, Epalza, Cristina, Fortuny, Clàudia, Colbers, Angela, Nastouli, Eleni, Walker, Simon, Carr, Dan, Conway, Magda, Spyer, Moira J., Parkar, Nazia, White, Iona, Nardone, Alessandra, Thomason, Margaret J., Ferrand, Rashida A., Giaquinto, Carlo, Ford, Deborah

“…There is increasing interest in utilising two-drug regimens for HIV treatment with the goal of reducing toxicity and improve acceptability. The D3 trial…”
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Risk factors, symptom reporting, healthcare-seeking behaviour and adherence to public health guidance: protocol for Virus Watch, a prospective community cohort study by Hayward, Andrew, Fragaszy, Ellen, Kovar, Jana, Nguyen, Vincent, Beale, Sarah, Byrne, Thomas, Aryee, Anna, Hardelid, Pia, Wijlaars, Linda, Fong, Wing Lam Erica, Geismar, Cyril, Patel, Parth, Shrotri, Madhumita, Navaratnam, Annalan M D, Nastouli, Eleni, Spyer, Moira, Killingley, Ben, Cox, Ingemar, Lampos, Vasileios, McKendry, Rachel A, Liu, Yunzhe, Cheng, Tao, Johnson, Anne M, Michie, Susan, Gibbs, Jo, Gilson, Richard, Rodger, Alison, Aldridge, Robert W

“…IntroductionThe coronavirus (COVID-19) pandemic has caused significant global mortality and impacted lives around the world. Virus Watch aims to provide…”
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Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe by Prendergast, Andrew J, Berejena, Chipo, Pimundu, Godfrey, Shonhai, Annie, Bwakura-Dangarembizi, Mutsa, Musiime, Victor, Szubert, Alexander J, Cook, Adrian D, Spyer, Moira J, Nahirya-Ntege, Patricia, Kekitiinwa, Adeodata, Gibb, Diana M, Klein, Nigel, Walker, A Sarah

“…OBJECTIVES:A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We…”
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Eyeglasses and risk of COVID-19 transmission-analysis of the Virus Watch Community Cohort study by Navaratnam, Annalan M D, O'Callaghan, Christopher, Beale, Sarah, Nguyen, Vincent, Aryee, Anna, Braithwaite, Isobel, Byrne, Thomas E, Fong, Wing Lam Erica, Fragaszy, Ellen, Geismar, Cyril, Hoskins, Susan, Kovar, Jana, Patel, Parth, Shrotri, Madhumita, Weber, Sophie, Yavlinsky, Alexei, Aldridge, Robert W, Hayward, Andrew C

“…The importance of SARS-CoV-2 transmission via the eyes is unknown, with previous studies mainly focusing on protective eyewear in healthcare settings. This…”
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Low unspliced cell-associated HIV RNA in early treated adolescents living with HIV on long suppressive ART by Gärtner, Kathleen, Domínguez-Rodríguez, Sara, Heaney, Judith, Gkouleli, Triantafylia, Grant, Paul, Dorgham, Karim, Sauce, Delphine, Soulie, Cathia, Busby, Eloise J, O'Sullivan, Denise M, Spyer, Moira, Botha, Johannes C, Muñoz-Fernandez, Maria Angeles, Tagarro, Alfredo, Cotugno, Nicola, Huggett, Jim F, Klein, Nigel, Palma, Paolo, Rojo Conejo, Pablo, Foster, Caroline, Giaquinto, Carlo, Rossi, Paolo, Persaud, Deborah, De Rossi, Anita, Marcelin, Anne-Geneviève, Nastouli, Eleni

“…Initiation of antiretroviral treatment (ART) in patients early after HIV-infection and long-term suppression leads to low or undetectable levels of HIV RNA and…”
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