Search Results - "Spyer, K M"

Annual review prize lecture. Central nervous mechanisms contributing to cardiovascular control by Spyer, K M

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Coexpression of Rat P2X2 and P2X6 Subunits in Xenopus Oocytes by King, B. F, Townsend-Nicholson, A, Wildman, S. S, Thomas, T, Spyer, K. M, Burnstock, G

“…Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat…”
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ATP as a mediator of mammalian central CO2 chemoreception by Thomas, T., Spyer, K. M.

“…A role for P2 purinoceptors in the chemosensory response of respiratory neurones localised in the ventrolateral medulla to changes in arterial CO 2 levels was…”
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Evidence for the involvement of purinergic signalling in the control of respiration by Thomas, T, Ralevic, V, Bardini, M, Burnstock, G, Spyer, K.M

“…The ventrolateral medulla has a critical role in the generation and patterning of respiration via an extensive network of respiratory neurones. We have…”
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A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat by Dawid Milner, M.S., Lara, J.P., López de Miguel, M.P., López-González, M.V., Spyer, K.M., González-Barón, S.

“…We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex (PB) in spontaneously breathing…”
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Localisation of P2X2 receptor subunit immunoreactivity on nitric oxide synthase expressing neurones in the brain stem and hypothalamus of the rat: A fluorescence immunohistochemical study by YAO, S. T, GOURINE, A. V, SPYER, K. M, BARDEN, J. A, LAWRENCE, A. J

“…A large body of evidence suggests that nitric oxide (NO) and ATP act as neurotransmitters in the regulatory mechanisms concerning several autonomic functions…”
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Central CO2 chemoreception: a mechanism involving P2 purinoceptors localized in the ventrolateral medulla of the anaesthetized rat by Thomas, T., Ralevic, V., Gadd, C. A., Spyer, K. M.

“…The involvement of P2 purinoceptors in chemosensory function in the ventrolateral regions of the medulla oblongata was investigated in the anaesthetized rat…”
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Characterization of P2 receptors modulating neural activity in rat rostral ventrolateral medulla by Ralevic, V., Thomas, T., Burnstock, G., Spyer, K.M.

“…This study investigated the effects of ATP, and related compounds, on the activity of neurons within the rostral ventrolateral medulla, an area of fundamental…”
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A novel influence of adenosine on ongoing activity in rat rostral ventrolateral medulla by Thomas, T., Spyer, K.M.

“…We have investigated whether exogenously applied adenosine modulates neuronal activity in a region of the central nervous system crucial for cardiovascular…”
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Convergence Properties of Solitary Tract Neurons Responsive to Cardiac Receptor Stimulation in the Anesthetized Cat by Silva-Carvalho, L, Paton, J.F.R, Rocha, I, Goldsmith, G. E, Spyer, K. M

“…L. Silva-Carvalho 1 , J.F.R. Paton 2 , I. Rocha 1 , G. E. Goldsmith 1 , and K. M. Spyer 1 1  Department of Physiology, Autonomic Neuroscience Institute, Royal…”
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Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat by Lara, J.P, Dawid-Milner, M.S, López, M.V, Montes, C, Spyer, K.M, González-Barón, S

“…In order to study the importance of two pontine regions modulating laryngeal resistance, electrical current or microinjections of glutamate (10–30 nl, 1–3…”
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Localization of cardiac vagal preganglionic motoneurones in the rat: immunocytochemical evidence of synaptic inputs containing 5-hydroxytryptamine by Izzo, P N, Deuchars, J, Spyer, K M

“…The origin of cardiac vagal preganglionic motoneurones in the rat is still controversial and knowledge of the chemistry of synaptic inputs onto these neurones…”
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Cardiovascular and respiratory effects of stimulation of cell bodies of the parabrachial nuclei in the anaesthetized rat by Lara, J P, Parkes, M J, Silva-Carvhalo, L, Izzo, P, Dawid‐Milner, M S, Spyer, K M

“…1. In order to assess the importance of the parabrachial nuclei in modulating cardiorespiratory activity, electric current or microinjections of glutamate were…”
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A role for adenosine in modulating cardio-respiratory responses: a mini-review by Spyer, K.M, Thomas, T

“…Evidence is provided that purine nucleotides play a major role in modulating cardio-respiratory control through actions at specific sites in the central…”
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The actions of baclofen on neurones and synaptic transmission in the nucleus tractus solitarii of the rat in vitro by Brooks, P A, Glaum, S R, Miller, R J, Spyer, K M

“…1. Intracellular and whole-cell patch recordings were made from sixty-seven neurones located in the nucleus tractus solitarii (NTS) in transverse slices of rat…”
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Central nervous mechanisms contributing to cardiovascular control by SPYER, K. M

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Neural mechanisms involved in cardiovascular control during affective behaviour by Spyer, K M

“…The changes in respiration and cardiovascular output seen during mammalian defensive behaviour are no longer considered to be the product of simple reflexes…”
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A source of adenosine involved in cardiovascular responses to defense area stimulation by St Lambert, J H, Thomas, T, Burnstock, G, Spyer, K M

“…We have investigated the source of central adenosine important in modulating the cardiovascular response to hypothalamic defense area (HDA) stimulation in…”
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Demonstration of glutamate immunoreactivity in vagal sensory afferents in the nucleus tractus solitarius of the rat by Sykes, R.M., Spyer, K.M., Izzo, P.N.

“…To investigate whether glutamate is a neurotransmitter in vagus nerve sensory afferents terminating in the nucleus tractus solitarius, these terminals were…”
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Somatosympathetic reflex in a working heart-brainstem preparation of the rat by Potts, J.T, Spyer, K.M, Paton, J.F.R

“…The purpose of the present study was to examine the cardiorespiratory responses (CR) evoked by a somatosympathetic reflex (SSR) in the working heart-brainstem…”
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