Search Results - "Spurlock, Michael E."

The development of porcine models of obesity and the metabolic syndrome by Spurlock, Michael E, Gabler, Nicholas K

“…Despite aggressive research aimed at understanding the myriad biochemical factors that are integrated to balance energy intake and expenditure to maintain…”
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Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat by Davis, Jeremy E, Gabler, Nicholas K, Walker-Daniels, Jennifer, Spurlock, Michael E

“…Toll‐like receptor‐4 (Tlr‐4), a key pattern recognition receptor involved in innate immune response, is activated by saturated fatty acids (SFAs). To…”
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Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes by Davis, Jeremy E., Braucher, Douglas R., Walker-Daniels, Jennifer, Spurlock, Michael E.

“…We have previously shown that toll-like receptor-4 (Tlr4) is involved in obesity-induced inflammation in adipose tissue (AT). However, less is known about the…”
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Effects of triacylglycerol structure and solid fat content on fasting responses of mice by Wang, Xiaosan, Wang, Tong, Spurlock, Michael E., Wang, Xingguo

“…Purpose Fat randomization and interesterification change triacylglycerol (TAG) structure and its solid fat content profile. It has not been thoroughly…”
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Effect of a mitochondria-targeted vitamin E derivative on mitochondrial alteration and systemic oxidative stress in mice by Mao, Gaowei, Kraus, George A., Kim, Ikyon, Spurlock, Michael E., Bailey, Theodore B., Beitz, Donald C.

“…The objective of the present study was to determine whether a mitochondria-targeted vitamin E derivative (MitoVit E) would affect certain mitochondrial…”
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Weaning anorexia may contribute to local inflammation in the piglet small intestine by McCracken, B A, Spurlock, M E, Roos, M A, Zuckermann, F A, Gaskins, H R

“…Compromising alterations in villus-crypt structure are common in pigs postweaning. Possible contributions of local inflammatory reactions to villus-crypt…”
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Characterization of β-adrenergic receptors in bovine intramuscular and subcutaneous adipose tissue: comparison of lubabegron fumarate with β-adrenergic receptor agonists and antagonists by Hwang, Jinhee H, Spurlock, Michael E, Kube, John C, Li, Xiang Z, Smith, Stephen B

“…Abstract Chinese hamster ovary cell constructs expressing either the β 1-, β 2- or β 3-adrenergic receptor (AR) were used to determine whether a novel β-AR…”
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Myostatin null mice respond differently to dietary-induced and genetic obesity by Dilger, Anna C, Spurlock, Michael E, Grant, Alan L, Gerrard, David E

“…Our objective was to determine sensitivity of myostatin null (MN) mice to obesity induction by dietary or genetic means. To induce dietary obesity, 3-week-old…”
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Adiponectin differentially regulates cytokines in porcine macrophages by Wulster-Radcliffe, Meghan C, Ajuwon, Kolapo M, Wang, Jiazhen, Christian, John A, Spurlock, Michael E

“…Adiponectin, an adipocyte-derived hormone, attenuates the production of TNFα by activated human macrophages. In the present study, we used porcine…”
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A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice by Mao, Gaowei, Kraus, George A, Kim, Ikyon, Spurlock, Michael E, Bailey, Theodore B, Zhang, Qijing, Beitz, Donald C

“…Our objective in this study was to determine whether a mitochondria-targeted vitamin E derivative (MitoVit E) would decrease oxidative stress and associated…”
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In utero and postnatal exposure to long chain (n-3) PUFA enhances intestinal glucose absorption and energy stores in weanling pigs by Gabler, Nicholas K, Spencer, Joel D, Webel, Doug M, Spurlock, Michael E

“…The aim of this research was to determine whether feeding gestating and lactating sows (n-3) PUFA [eicosapentaenoic acid (EPA) and/or docosahexenoic acid…”
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Feeding long-chain n−3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK by Gabler, Nicholas K., Radcliffe, J. Scott, Spencer, Joel D., Webel, Doug M., Spurlock, Michael E.

“…The current study utilized Ussing chambers to examine the impact of supplementing maternal gestation and/or lactation diets with n−3 polyunsaturated fatty…”
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Early Lesion Formation in Colorectal Carcinogenesis Is Associated With Adiponectin Status Whereas Neoplastic Lesions Are Associated With Diet and Sex in C57BL/6J Mice by Boddicker, Rebecca L., Whitley, Elizabeth, Birt, Diane F., Spurlock, Michael E.

“…Adiponectin is an antiinflammatory and insulin-sensitizing hormone that is decreased in obesity. Although controversial, it has been suggested that decreased…”
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The biology of leptin: a review by Houseknecht, K.L. (Purdue University, West Lafayette, IN.), Baile, C.A, Matteri, R.L, Spurlock, M.E

“…Leptin, a 16-kDa protein secreted from white adipocytes, has been implicated in the regulation of food intake, energy expenditure, and whole-body energy…”
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n-3 PUFA attenuate lipopolysaccharide-induced down-regulation of toll-like receptor 4 expression in porcine adipose tissue but does not alter the expression of other immune modulators by Gabler, Nicholas K., Spencer, Joel D., Webel, Doug M., Spurlock, Michael E.

“…The objective of this study was to test the hypothesis that the inflammatory response to lipopolysaccharide (LPS) in vivo is accompanied by down-regulation of…”
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Inflammation in Response to n3 Fatty Acids in a Porcine Obesity Model by Faris, Richard J, Boddicker, Rebecca L, Walker-Daniels, Jennifer, Li, Jenny, Jones, Douglas E, Spurlock, Michael E

“…Fatty acids have distinct cellular effects related to inflammation and insulin sensitivity. Dietary saturated fat activates toll-like receptor 4, which in turn…”
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Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes by Ajuwon, Kolapo M, Spurlock, Michael E

“…We recently provided evidence that interleukin-15 (IL-15) is expressed lowly in the pig adipocyte and that interferon-gamma (IFN-gamma) markedly increases this…”
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Low-Dose Dietary Resveratrol Has Differential Effects on Colorectal Tumorigenesis in Adiponectin Knockout and Wild-Type Mice by Boddicker, Rebecca L, Whitley, Elizabeth M, Davis, Jeremy E, Birt, Diane F, Spurlock, Michael E

“…Obesity is associated with a decrease in the antiinflammatory hormone, adiponectin, and increases in the circulating concentrations of multiple proinflammatory…”
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Intracoronary adiponectin at reperfusion reduces infarct size in a porcine myocardial infarction model by Dębiński, Marcin, Buszman, Piotr, Milewski, Krzysztof, Wojakowski, Wojciech, Jackiewicz, Wanda, Pająk, Jacek, Szurlej, Dariusz, Fryc-Stanek, Joanna, Wiernek, Szymon, Jelonek, Michal, Spurlock, Michael, Martin, Jack, Bochenek, Andrzej, Buszman, Pawel

“…Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the…”
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Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes by Ajuwon, Kolapo M, Jacobi, Sheila K, Kuske, Joanne L, Spurlock, Michael E

“…3T3-L1 adipocytes express the lipopolysaccharide (LPS) receptor and respond to direct stimulation with the antigen by increasing the expression of inflammatory…”
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