Search Results - "Spurgin, Stephen B."

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice by Vishvanath, Lavanya, MacPherson, Karen A., Hepler, Chelsea, Wang, Qiong A., Shao, Mengle, Spurgin, Stephen B., Wang, Margaret Y., Kusminski, Christine M., Morley, Thomas S., Gupta, Rana K.

“…The expansion of white adipose tissue (WAT) in obesity involves de novo differentiation of new adipocytes; however, the cellular origin of these cells remains…”
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Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program by Shao, Mengle, Ishibashi, Jeff, Kusminski, Christine M., Wang, Qiong A., Hepler, Chelsea, Vishvanath, Lavanya, MacPherson, Karen A., Spurgin, Stephen B., Sun, Kai, Holland, William L., Seale, Patrick, Gupta, Rana K.

“…The transcriptional regulators Ebf2 and Prdm16 establish and maintain the brown and/or beige fat cell identity. However, the mechanisms operating in white…”
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Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction by Schiattarella, Gabriele G., Altamirano, Francisco, Kim, Soo Young, Tong, Dan, Ferdous, Anwarul, Piristine, Hande, Dasgupta, Subhajit, Wang, Xuliang, French, Kristin M., Villalobos, Elisa, Spurgin, Stephen B., Waldman, Maayan, Jiang, Nan, May, Herman I., Hill, Theodore M., Luo, Yuxuan, Yoo, Heesoo, Zaha, Vlad G., Lavandero, Sergio, Gillette, Thomas G., Hill, Joseph A.

“…Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and…”
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Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure by Sun, Kai, Kusminski, Christine M, Luby-Phelps, Kate, Spurgin, Stephen B, An, Yu A, Wang, Qiong A, Holland, William L, Scherer, Philipp E

“…Abstract We recently reported that local overexpression of VEGF-A in white adipose tissue (WAT) protects against diet-induced obesity and metabolic…”
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Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges by Ye, Risheng, Wang, Miao, Wang, Qiong A, Spurgin, Stephen B, Wang, Zhao V, Sun, Kai, Scherer, Philipp E

“…Abstract Background Evidence hints at the ability of β-cells to emerge from non-β-cells upon genetic or pharmacological interventions. However, their…”
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MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity by Kusminski, Christine M, Holland, William L, Sun, Kai, Park, Jiyoung, Spurgin, Stephen B, Lin, Ying, Askew, G Roger, Simcox, Judith A, McClain, Don A, Li, Cai, Scherer, Philipp E

“…Obesity is often associated with mitochondrial dysfunction. What is not clear, however, is whether this is a cause or a consequence of the condition and its…”
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MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk by Kusminski, Christine M, Chen, Shiuhwei, Ye, Risheng, Sun, Kai, Wang, Qiong A, Spurgin, Stephen B, Sanders, Phillip E, Brozinick, Joseph T, Geldenhuys, Werner J, Li, Wen-Hong, Unger, Roger H, Scherer, Philipp E

“…Mitochondrial metabolism plays an integral role in glucose-stimulated insulin secretion (GSIS) in β-cells. In addition, the diabetogenic role of glucagon…”
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Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice by Stone, Kirsten P., Wanders, Desiree, Calderon, Lucie F., Spurgin, Stephen B., Scherer, Philipp E., Gettys, Thomas W.

“…Objective Dietary methionine restriction (MR) reduces adiposity and hepatic lipids and increases overall insulin sensitivity in part by reducing lipogenic gene…”
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Abstract 13192: Xbp1s - Foxo1 Axis Governs Lipid Accumulation and Cardiac Performance in Heart Failure With Preserved Ejection Fraction by Schiattarella, Gabriele G, Altamirano, Francisco J, Tong, Dan, Kim, Esther, Ferdous, Anwarul, Piristine, Hande, Dasgupta, Subhajit, Wang, Xuliang, French, Kristin, Villalobos, Elisa, Spurgin, Stephen B, Hotiner Waldman, Mayaan, Jiang, Nan, May, Herman, Hill, Theodore M, Zaha, Vlad G, Lavandero, Sergio, Gillette, Thomas G, Hill, Joseph A

“…IntroductionHeart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure (HF). Limited insight into underlying mechanisms…”
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MitoNEET-Parkin Effects in Pancreatic [alpha]- and [Beta]-Cells, Cellular Survival, and Intrainsular Cross Talk by Kusminski, Christine M, Chen, Shiuhwei, Ye, Risheng, Sun, Kai, Wang, Qiong A, Spurgin, Stephen B, Sanders, Phillip E, Brozinick, Joseph T, Geldenhuys, Werner J, Li, Wen-hong, Unger, Roger H, Scherer, Philipp E

“…Mitochondrial metabolism plays an integral role in glucose-stimulated insulin secretion (GSIS) in ...-cells. In addition, the diabetogenic role of glucagon…”
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MitoNEET, a key regulator of mitochondrial function and lipid homeostasis by Kusminski, Christine M., Holland, William L., Sun, Kai, Park, Jiyoung, Spurgin, Stephen B., Lin, Ying, Askew, G. Roger, Simcox, Judith A., McClain, Don A., Li, Cai, Scherer, Philipp E.

“…We examined rodent models with altered levels of mitoNEET, a protein residing in the mitochondrial outer membrane. Adipocyte-specific overexpression of…”
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