Search Results - "Spuhler, Philipp"

Microfluidic, marker-free isolation of circulating tumor cells from blood samples by Karabacak, Nezihi Murat, Spuhler, Philipp S, Fachin, Fabio, Lim, Eugene J, Pai, Vincent, Ozkumur, Emre, Martel, Joseph M, Kojic, Nikola, Smith, Kyle, Chen, Pin-i, Yang, Jennifer, Hwang, Henry, Morgan, Bailey, Trautwein, Julie, Barber, Thomas A, Stott, Shannon L, Maheswaran, Shyamala, Kapur, Ravi, Haber, Daniel A, Toner, Mehmet

“…The ability to isolate and analyze rare circulating tumor cells (CTCs) has the potential to further our understanding of cancer metastasis and enhance the care…”
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Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells by Ozkumur, Emre, Shah, Ajay M, Ciciliano, Jordan C, Emmink, Benjamin L, Miyamoto, David T, Brachtel, Elena, Yu, Min, Chen, Pin-i, Morgan, Bailey, Trautwein, Julie, Kimura, Anya, Sengupta, Sudarshana, Stott, Shannon L, Karabacak, Nezihi Murat, Barber, Thomas A, Walsh, John R, Smith, Kyle, Spuhler, Philipp S, Sullivan, James P, Lee, Richard J, Ting, David T, Luo, Xi, Shaw, Alice T, Bardia, Aditya, Sequist, Lecia V, Louis, David N, Maheswaran, Shyamala, Kapur, Ravi, Haber, Daniel A, Toner, Mehmet

“…Circulating tumor cells (CTCs) are shed into the bloodstream from primary and metastatic tumor deposits. Their isolation and analysis hold great promise for…”
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Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells by Fachin, Fabio, Spuhler, Philipp, Martel-Foley, Joseph M., Edd, Jon F., Barber, Thomas A., Walsh, John, Karabacak, Murat, Pai, Vincent, Yu, Melissa, Smith, Kyle, Hwang, Henry, Yang, Jennifer, Shah, Sahil, Yarmush, Ruby, Sequist, Lecia V., Stott, Shannon L., Maheswaran, Shyamala, Haber, Daniel A., Kapur, Ravi, Toner, Mehmet

“…Circulating tumor cells (CTCs) are a treasure trove of information regarding the location, type and stage of cancer and are being pursued as both a diagnostic…”
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Quantitative characterization of conformational-specific protein-DNA binding using a dual-spectral interferometric imaging biosensor by Zhang, Xirui, Daaboul, George G, Spuhler, Philipp S, Dröge, Peter, Ünlü, M Selim

“…DNA-binding proteins play crucial roles in the maintenance and functions of the genome and yet, their specific binding mechanisms are not fully understood…”
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Quantification of surface etching by common buffers and implications on the accuracy of label-free biological assays by Ahn, Sunmin, Spuhler, Philipp S., Chiari, Marcella, Cabodi, Mario, Selim Ünlü, M.

“…High throughput analyses in biochemical assays are gaining popularity in the post-genomic era. Multiple label-free detection methods are especially of…”
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Floating light-activated microelectrical stimulators tested in the rat spinal cord by Abdo, Ammar, Sahin, Mesut, Freedman, David S, Cevik, Elif, Spuhler, Philipp S, Unlu, M Selim

“…Microelectrodes of neural stimulation utilize fine wires for electrical connections to driving electronics. Breakage of these wires and the neural tissue…”
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Synthesis and conformational characterization of functional di-block copolymer brushes for microarray technology by Di Carlo, Gabriele, Damin, Francesco, Armelao, Lidia, Maccato, Chiara, Unlu, Selim, Spuhler, Philipp S., Chiari, Marcella

“…► Microarray glass slides were functionalized with block polymer brushes. ► The coating was characterized by Self Spectral Interference Fluorescence…”
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Nanoscale characterization of DNA conformation using dual-color fluorescence axial localization and label-free biosensing by Zhang, Xirui, Daaboul, George G, Spuhler, Philipp S, Freedman, David S, Yurt, Abdulkadir, Ahn, Sunmin, Avci, Oguzhan, Ünlü, M Selim

“…Quantitative determination of the density and conformation of DNA molecules tethered to the surface can help optimize and understand DNA nanosensors and…”
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Platform for in situ real-time measurement of protein-induced conformational changes of DNA by Spuhler, Philipp S, Knežević, Jelena, Yalçin, Ayça, Bao, Qiuye, Pringsheim, Erika, Dröge, Peter, Rant, Ulrich, Ünlü, M. Selim

“…A platform for in situ and real-time measurement of protein-induced conformational changes in dsDNA is presented. We combine electrical orientation of…”
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Precisely Controlled Smart Polymer Scaffold for Nanoscale Manipulation of Biomolecules by Spuhler, Philipp S, Sola, Laura, Zhang, Xirui, Monroe, Margo R, Greenspun, Joseph T, Chiari, Marcella, Ünlü, M. Selim

“…We demonstrate the application of a novel smart surface to modulate the orientation of immobilized double stranded DNA (dsDNA) and the conformation of a…”
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On the Existence of CuI Pairs in ZSM-5-A Computational Study by Spuhler, Philipp, Holthausen, Max C., Nachtigallová, Dana, Nachtigall, Petr, Sauer, Joachim

“…The siting and coordination of CuI pairs in zeolite ZSM‐5 have been studied by means of a combined quantum mechanics/interatomic potential function technique…”
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In Vitro Testing of Floating Light Activated Micro-Electrical Stimulators by Abdo, A., Jayasinha, V., Spuhler, P.S., Unlu, M.S., Sahin, M.

“…Chronic tissue response to microelectrode implants stands in the way as a major challenge to development of many neural prosthetic applications. The long term…”
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A nanoelectromechanical biosensor based on precise quantification and control of DNA orientation by Spuhler, P. S., Sola, L., Xirui Zhang, Monroe, M., Greenspun, J., Chiari, M., Unlu, M. S.

“…We utilize spectral self-interference fluorescent microscopy (SSFM) to measure fluorophore height with sub-nm precision to precisely quantify DNA orientation…”
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Measurement of potential dependent DNA orientation on Indium Tin Oxide surfaces by fluorescent-self interference microscopy by Spuhler, Philipp S, Sola, Laura, Monroe, Margo R, Chiari, Marcella, Ünlü, M Selim

“…We present a platform for the measurement of DNA orientation on an Indium Tin Oxide surface. We apply an interferometric measurement technique called spectral…”
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Mechanism of the Aliphatic Hydroxylation Mediated by a Bis(μ-oxo)dicopper(III) Complex by Spuhler, Philipp, Holthausen, Max C.

“…The core of the problem: The selective hydroxylation of benzylic CH bonds by a [Cu2O2]2+ core is a nonsynchronous concerted process (see scheme). This is the…”
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High-throughput detection of DNA orientation and conformation for characterization of protein-DNA interactions by Spuhler, Philipp S

“…A deep understanding of disease processes requires understanding of DNA, RNA and protein function on a molecular level. Protein-DNA interactions play a crucial…”
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Mechanismus der aliphatischen Hydroxylierung mit einem Bis(μ‐oxo)dikupfer(III)‐Komplex by Spuhler, Philipp, Holthausen, Max C.

“…Die selektive Hydroxylierung benzylischer C‐H‐Bindungen durch eine [Cu2O2]2+‐Einheit ist ein nichtsynchroner konzertierter Prozess (siehe Schema). Dieses…”
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Theoretical Studies of Inorganic Compounds. 27 Quantum Chemical Investigations of Transition Metal Nitrido Complexes with a TM-N-E Linkage (E = Main Group Element) by Spuhler, Philipp, Lein, Matthias, Frenking, Gernot

“…It is reported about quantum chemical DFT calculations of various transition metal (TM) nitrido complexes which contain a TM‐N‐E linkage. The goal is to…”
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High-throughput detection of DNA orientation and conformation for characterization of protein-DNA interactions by Spuhler, Philipp S

“…A deep understanding of disease processes requires understanding of DNA, RNA and protein function on a molecular level. Protein-DNA interactions play a crucial…”
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Mechanismus der aliphatischen Hydroxylierung mit einem Bis(μ-oxo)dikupfer(III)-Komplex by Spuhler, Philipp, Holthausen, Max C.

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