Search Results - "Spruck, Charles H."

Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins by Liberal, Vasco, Martinsson-Ahlzén, Hanna-Stina, Liberal, Jennifer, Spruck, Charles H, Widschwendter, Martin, McGowan, Clare H, Reed, Steven I

“…Cyclin-dependent kinase subunit (Cks) proteins are small cyclin-dependent kinase-interacting proteins that are frequently overexpressed in breast cancer, as…”
Get full text

Cyclin-Dependent Kinase-Associated Proteins Cks1 and Cks2 Are Essential during Early Embryogenesis and for Cell Cycle Progression in Somatic Cells by Martinsson-Ahlzén, Hanna-Stina, Liberal, Vasco, Grünenfelder, Björn, Chaves, Susana R, Spruck, Charles H, Reed, Steven I

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line by Reed, Steven I, Strohmaier, Heimo, Spruck, Charles H, Kaiser, Peter, Won, Kwang-Ai, Sangfelt, Olle

“…Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is expressed near the G1-S phase transition and is thought to be critical for the…”
Get full text

Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer by REED, Susanna Ekholm, SPRUCK, Charles H, SANGFELT, Olle, VAN DROGEN, Frank, MUELLER-HOLZNER, Elisabeth, WIDSCHWENDTER, Martin, ZETTERBERG, Anders, REED, Steven I

“…hCDC4, the gene that encodes the F-box protein responsible for targeting cyclin E for ubiquitin-mediated proteolysis, has been found to be mutated in a number…”
Get full text

Requirement of Cks2 for the First Metaphase/Anaphase Transition of Mammalian Meiosis by Spruck, Charles H., de Miguel, Maria P., Adrian P. L. Smith, Ryan, Aimee, Stein, Paula, Schultz, Richard M., Lincoln, A. Jeannine, Donovan, Peter J., Reed, Steven I.

“…We generated mice lacking Cks2, one of two mammalian homologs of the yeast Cdki-binding proteins, Suc1 and Cks1, and found them to be viable but sterile in…”
Get full text

Cyclin E dysregulation and chromosomal instability in endometrial cancer by HUBALEK, Michael M, WIDSCHWENDTER, Andreas, REED, Steven I, WIDSCHWENDTER, Martin, ERDEL, Martin, GSCHWENDTNER, Andreas, FIEGL, Heidi M, MÜLLER, Hannes M, GOEBEL, Georg, MUELLER-HOLZNER, Elisabeth, MARTH, Christian, SPRUCK, Charles H

“…Deregulation of cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2), has been associated with a broad spectrum of human malignancies. Yet the mechanism…”
Get full text

Evidence for Multiclonality in Multicentric Kaposi's Sarcoma by Gill, Parkash S., Tsai, Yvonne C., Rao, Adupa P., Spruck, Charles H., Zheng, Tong, Harrington, William A., Cheung, Tony, Nathwani, Bharat, Jones, Peter A.

“…Kaposi's sarcoma (KS) develops in a variety of clinical states and is the most common tumor seen in patients with HIV-1 infection. KS develops as a multifocal…”
Get full text

Deregulated cyclin E induces chromosome instability by Reed, Steven I, Spruck, Charles H, Won, Kwang-Ai

“…Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (Cdk2), is an important regulator of entry into S phase in the mammalian cell cycle. In normal…”
Get full text

hCDC4 gene mutations in endometrial cancer by SPRUCK, Charles H, STROHMAIER, Heimo, SANGFELT, Olle, MÜLLER, Hannes M, HUBALEK, Michael, MÜLLER-HOLZNER, Elisabeth, MARTH, Christian, WIDSCHWENDTER, Martin, REED, Steven I

“…Cyclin-dependent kinase 2 activated by cyclin E is involved in the initiation of DNA replication and other S phase functions. Consistent with this role, cyclin…”
Get full text

Methylation, mutation and cancer by Jones, P A, Rideout, 3rd, W M, Shen, J C, Spruck, C H, Tsai, Y C

“…The fifth base in human DNA, 5-methylcytosine, is inherently mutagenic. This has led to marked changes in the distribution of the CpG methyl acceptor site and…”
Get more information

Seek and Destroy: SCF Ubiquitin Ligases in Mammalian Cell Cycle Control by Spruck, Charles, Strohmaier, Heimo M.

“…The eukaryotic cell cycle consists of a series of sequential phases, the order of which is highly regulated to ensure the faithful transmission of intact…”
Get full text

Two molecular pathways to transitional cell carcinoma of the bladder by SPRUCK, C. H, OHNESEIT, P. F, DUBEAU, L, NICHOLS, P. W, HERMANN, G. G, STEVEN, K, HORN, T, SKINNER, D. G, JONES, P. A, GONZALEZ-ZULUETA, M, ESRIG, D, MIYAO, N, TSAI, Y. C, LERNER, S. P, SCHMÜTTE, C, YANG, A. S, COTE, R

“…Noninvasive transitional cell carcinomas of the bladder can have two distinct morphologies suggesting they contain different genetic alterations. Papillary…”
Get full text

P16 gene in uncultured tumours by Spruck, Charles H, Gonzalez-Zulueta, Mirella, Shibata, Atsuko, Simoneau, Anne R, Lin, Ming-Fong, Gonzales, Felicidad, Tsai, Yvonne C, Jones, Peter A

Get full text

Microsatellite instability in bladder cancer by GONZALEZ-ZULUETA, M, RUPPERT, J. M, SUMMERHAYES, I. C, SIDRANSKY, D, JONES, P. A, TOKINO, K, TSAI, Y. C, SPRUCK, C. H, MIYAO, N, NICHOLS, P. W, HERMANN, G. G, HORN, T, STEVEN, K

“…Somatic instability at microsatellite repeats was detected in 6 of 200 transitional cell carcinomas of the bladder. Instabilities were apparent as changes in…”
Get full text

Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations by SIMONEAU, A. R, SPRUCK, C. H, GONZALEZ-ZULUETA, M, GONZALGO, M. L, CHAN, M. F, TSAI, Y. C, DEAN, M, STEVEN, K, HORN, T, JONES, P. A

“…The most common genetic alteration identified to date in bladder cancer is loss of heterozygosity (LOH) of chromosome 9, suggesting the presence of possible…”
Get full text

Role of chromosome 9 in human bladder cancer by MIYAO, N, TSAI, Y. C, LERNER, S. P, OLUMI, A. F, SPRUCK, C. H, GONZALEZ-ZULUETA, M, NICHOLS, P. W, SKINNER, D. G, JONES, P. A

“…The tumors of 20 patients with multifocal primary transitional cell carcinoma of the bladder or lymph node metastases were examined for molecular genetic…”
Get full text

Distinct pattern of p53 mutations in bladder cancer : relationship to tobacco usage by SPRUCK, C. H, RIDEOUT, W. M, ROSS, R. K, YU, M. C, JONES, P. A, OLUMI, A. F, OHNESEIT, P. F, YANG, A. S, TSAI, Y. C, NICHOLS, P. W, HORN, T, HERMANN, C. G, STEVEN, K

“…A distinct mutational spectrum for the p53 tumor suppressor gene in bladder carcinomas was established in patients with known exposures to cigarette smoke…”
Get full text

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3 by Robichaud, N, del Rincon, S V, Huor, B, Alain, T, Petruccelli, L A, Hearnden, J, Goncalves, C, Grotegut, S, Spruck, C H, Furic, L, Larsson, O, Muller, W J, Miller, W H, Sonenberg, N

“…The progression of cancers from primary tumors to invasive and metastatic stages accounts for the overwhelming majority of cancer deaths. Understanding the…”
Get full text

Absence of p53 gene mutations in primary nasopharyngeal carcinomas by Spruck, 3rd, C H, Tsai, Y C, Huang, D P, Yang, A S, Rideout, 3rd, W M, Gonzalez-Zulueta, M, Choi, P, Lo, K W, Yu, M C, Jones, P A

“…Alterations in the p53 tumor suppressor gene and Epstein-Barr virus status were investigated in 15 nasopharyngeal carcinoma (NPC) biopsies, 4 xenografts, and 2…”
Get full text

High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder by Gonzalez-Zulueta, M, Shibata, A, Ohneseit, P F, Spruck, 3rd, C H, Busch, C, Shamaa, M, El-Baz, M, Nichols, P W, Gonzalgo, M L, Elbaz M [corrected to El-Baz, M ]

“…In the Western Hemisphere, 90% of bladder cancers are transitional cell carcinomas, while only 7% are classified as squamous cell carcinomas. In contrast, in…”
Get more information