Search Results - "Spruance, Spotswood L"

Novel Composite Efficacy Measure To Demonstrate the Rationale and Efficacy of Combination Antiviral–Anti-Inflammatory Treatment for Recurrent Herpes Simplex Labialis by HULL, Christopher M, LEVIN, Myron J, TYRING, Stephen K, SPRUANCE, Spotswood L

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Single-dose, patient-initiated famciclovir: A randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis by Spruance, Spotswood L., Bodsworth, Neil, Resnick, Harvey, Conant, Marcus, Oeuvray, Claude, Gao, Joseph, Hamed, Kamal

“…The brief period of viral replication in recurrent herpes labialis lesions suggests shorter therapeutic regimens are a logical episodic treatment strategy. We…”
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Acyclovir Cream for Treatment of Herpes Simplex Labialis: Results of Two Randomized, Double-Blind, Vehicle-Controlled, Multicenter Clinical Trials by SPRUANCE, Spotswood L, NETT, Robert, MARBURY, Thomas, WOLFF, Ray, JOHNSON, James, SPAULDING, Theodore

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Early treatment of cold sores with topical ME-609 decreases the frequency of ulcerative lesions: A randomized, double-blind, placebo-controlled, patient-initiated clinical trial by Hull, Christopher M., MD, Harmenberg, Johan, MD, PhD, Arlander, Eva, PhD, Aoki, Fred, MD, Bring, Johan, PhD, Darpö, Börje, MD, PhD, Levin, Myron J., MD, Tyring, Stephen, MD, PhD, Spruance, Spotswood L., MD

“…Background Prior pilot studies support the use of antiviral medications with topical corticosteroids for herpes simplex labialis (HSL). ME-609 (Xerese,…”
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High-Dose, Short-Duration, Early Valacyclovir Therapy for Episodic Treatment of Cold Sores: Results of Two Randomized, Placebo-Controlled, Multicenter Studies by SPRUANCE, Spotswood L, JONES, Terry M, BLATTER, Mark M, VARGAS-CORTES, Mauricio, BARBER, Judy, HILL, Joanne, GOLDSTEIN, Donna, SCHULTZ, Margaret

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Topical Iontophoretic Administration of Acyclovir for the Episodic Treatment of Herpes Labialis: A Randomized, Double-Blind, Placebo-Controlled, Clinic-Initiated Trial by Morrel, Eric M., Spruance, Spotswood L., Goldberg, Dennis I.

“…Background. Multiple studies of the use of acyclovir for the treatment of herpes labialis have suggested that the nominal efficacy of the topical formulation…”
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Application of a Topical Immune Response Modifier, Resiquimod Gel, to Modify the Recurrence Rate of Recurrent Genital Herpes: A Pilot Study by Spruance, Spotswood L., Tyring, Stephen K., Smith, Michael H., Meng, Tze-Chiang

“…Resiquimod (R-848), a topically active immune response modifier, induced production of interferon-α and interleukin-12 in cultured blood mononuclear cells and…”
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Evaluation of Imiquimod 5% Cream to Modify the Natural History of Herpes Labialis: A Pilot Study by Bernstein, David I., Spruance, Spotswood L., Arora, Sujata S., Schroeder, Jennifer L., Meng, Tze-Chiang

“…Background. Imiquimod is currently approved for the treatment of genital warts and has been shown to decrease recurrences of genital herpes in the guinea pig…”
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Hazard ratio in clinical trials by SPRUANCE, Spotswood L, REID, Julia E, GRACE, Michael, SAMORE, Matthew

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Recurrent Antiviral-Resistant Genital Herpes in an Immunocompetent Patient by Kriesel, John D., Spruance, Spotswood L., Prichard, Mark, Parker, Jacqueline N., Kern, Earl R.

“…Herpes simplex virus type 2 (HSV-2) resistance to antiviral drugs has been described primarily in immunocompromised patients. We report an apparently…”
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Glycoprotein-D–Adjuvant Vaccine to Prevent Genital Herpes by Stanberry, Lawrence R, Spruance, Spotswood L, Cunningham, Anthony L, Bernstein, David I, Mindel, Adrian, Sacks, Stephen, Tyring, Stephen, Aoki, Fred Y, Slaoui, Moncef, Denis, Martine, Vandepapeliere, Pierre, Dubin, Gary

“…Two double-blind, controlled trials assessed the efficacy of a glycoprotein-D–subunit vaccine to prevent genital herpes disease. The vaccine elicited humoral…”
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Peroral Famciclovir in the Treatment of Experimental Ultraviolet Radiation-Induced Herpes Simplex Labialis: A Double-Blind, Dose-Ranging, Placebo-Controlled, Multicenter Trial by Spruance, Spotswood L., Rowe, Nathaniel H., Raborn, G. Wayne, Thibodeau, Edward A., D'Ambrosio, Joseph A., Bernstein, David I.

“…Three doses of famciclovir were tested for treatment of experimental ultraviolet radiation (UVR)-induced herpes labialis. Patients received 125, 250, or 500 mg…”
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Transcranial Doppler quantification of residual shunt after percutaneous patent foramen ovale closure: correlation of device efficacy with intracardiac anatomic measures by Sorensen, Sherman G, Spruance, Spotswood L, Smout, Randall, Horn, Susan

“…Percutaneous, mechanical closure of defects of the atrial septum fails to completely resolve shunting in up to 20% of cases. Little is known about the factors…”
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Transcranial doppler quantification of residual shunt after percutaneous patent foramen ovale closure: efficacy of the GORE(®) HELEX septal occluder by Sorensen, Sherman G, Smout, Randall, Spruance, Spotswood L

“…Ideally, percutaneous, mechanical closure of defects of the atrial septum should completely resolve shunt. To achieve this goal, more information is needed…”
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Low-Intensity Laser Therapy for Recurrent Herpes Labialis by Rallis, Tena M., Spruance, Spotswood L.

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Prospects for Control of Herpes Simplex Virus Disease through Immunization by Stanberry, Lawrence R., Cunningham, Anthony L., Mindel, Adrian, Scott, Laurie L., Spruance, Spotswood L., Aoki, Fred Y., Lacey, Charles J.

“…Herpes simplex viruses (HSVs) can cause a variety of infections, including genital herpes. Despite effective antiviral therapy, HSV infections remain a…”
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Herpes simplex virus as a cause of Bell's palsy by McCormick, David P., Spruance, Reviewed by Spotswood L.

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N-docosanol (Abreva) for herpes labialis: Problems and questions by Spruance, Spotswood L.

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Clinical significance of antiviral therapy for episodic treatment of herpes labialis: exploratory analyses of the combined data from two valaciclovir trials by Spruance, Spotswood L., Hill, Joanne

“…Valaciclovir (Valtrex) 2 g twice daily for 1 day was recently approved in the United States for treatment of cold sores. In order to apply more clinically…”
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Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials by Raborn, G Wayne, Martel, Alain Y, Lassonde, Michel, Lewis, Michael A O, Boon, Ron, Spruance, Spotswood L

“…Two randomized, double-blind, parallel-group clinical trials were conducted in Europe and North America to compare the efficacy and safety of topical 1 percent…”
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