Search Results - "Spronk, HMH"

Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques by Dhore, Cherida R, Cleutjens, Jack P.M, Lutgens, Esther, Cleutjens, Kitty B.J.M, Geusens, Piet P.M, Kitslaar, Peter J.E.H.M, Tordoir, Jan H.M, Spronk, Henri M.H, Vermeer, Cees, Daemen, Mat J.A.P

“…In the present study, we examined the expression of regulators of bone formation and osteoclastogenesis in human atherosclerosis because accumulating evidence…”
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Role of vitamin K and vitamin K-dependent proteins in vascular calcification by Schurgers, L J, Dissel, P E, Spronk, H M, Soute, B A, Dhore, C R, Cleutjens, J P, Vermeer, C

“…To provide a rational basis for recommended daily allowances (RDA) of dietary phylloquinone (vitamin K1) and menaquinone (vitamin K2) intake that adequately…”
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Platelet‐ and erythrocyte‐derived microparticles trigger thrombin generation via factor XIIa by VAN DER MEIJDEN, P. E. J., VAN SCHILFGAARDE, M., VAN OERLE, R., RENNÉ, T., TEN CATE, H., SPRONK, H. M. H.

“…See also Shapiro S, Laffan M. Making contact with microparticles. This issue, pp 1352–4. Summary.  Background:  The procoagulant properties of microparticles…”
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Atrial fibrillation and age synergistically increase clotting potential and promote atrial structural remodeling in goats by D’ Alessandro, E, Scaf, B, Sobota, V, Van Hunnik, A, Kuiper, M, Winters, J, Van Oerle, R, Spronk, HMH, Van Nieuwenhoven, FA, Ten Cate, H, Verheule, S, Schotten, U

“…Abstract Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Netherlands Heart Foundation, European Union Background Age is a risk…”
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ATP‐gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation by LECUT, C., FACCINETTO, C., DELIERNEUX, C., van OERLE, R., SPRONK, H. M. H., EVANS, R. J., EL BENNA, J., BOURS, V., OURY, C.

“…Background:  In sepsis, extracellular ATP, secreted by activated platelets and leukocytes, may contribute to the crosstalk between hemostasis and inflammation…”
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Factor XII activation is essential to sustain the procoagulant effects of particulate matter by KILINÇ, E., VAN OERLE, R., BORISSOFF, J. I., OSCHATZ, C., GERLOFS‐NIJLAND, M. E., JANSSEN, N. A., CASSEE, F. R., SANDSTRÖM, T., RENNÉ, T., TEN CATE, H., SPRONK, H. M. H.

“…See also Mutch NJ. Emerging roles for factor XII in vivo. This issue, pp 1355–8. Summary.  Background: Particulate matter (PM) is a key component of ambient…”
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The blood coagulation system as a molecular machine by Spronk, Henri M.H., Govers-Riemslag, José W.P., ten Cate, Hugo

“…The human blood coagulation system comprises a series of linked glycoproteins that upon activation induce the generation of downstream enzymes ultimately…”
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The plasma kallikrein–kinin system and risk of cardiovascular disease in men by GOVERS‐RIEMSLAG, J. W. P., SMID, M., COOPER, J. A., BAUER, K. A., ROSENBERG, R. D., HACK, C. E., HAMULYAK, K., SPRONK, H. M. H., MILLER, G. J., TEN CATE, H.

“…Background: The plasma kallikrein–kinin system (PKKS) has been implicated in cardiovascular disease, but activation of the PKKS has not been directly probed in…”
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The Prothrombotic Paradox of Hypertension: Role of the Renin-Angiotensin and Kallikrein-Kinin Systems by Dielis, Arne W.J.H, Smid, Machiel, Spronk, Henri M.H, Hamulyak, Karly, Kroon, Abraham A, ten Cate, Hugo, de Leeuw, Peter W

“…Despite increased pulsatile stress, thrombotic rather than hemorrhagic events represent a major complication of hypertension. The pathophysiology of thrombosis…”
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Vitamin K epoxide reductase complex and vascular calcification: is this the important link between vitamin K and the arterial vessel wall? by Spronk, Henri M H

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The impact of antiproteinuric therapy on the prothrombotic state in patients with overt proteinuria by MAHMOODI, B. K., MULDER, A. B., WAANDERS, F., SPRONK, H. M. H., MULDER, R., SLAGMAN, M. C. J., VOGT, L., NAVIS, G., TEN CATE, H., KLUIN‐NELEMANS, H. C., LAVERMAN, G. D.

“…Background: Overt proteinuria is a strong risk factor for thromboembolism, owing to changes in the levels of various coagulation proteins and urinary…”
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Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats by Spronk, H M H, Soute, B A M, Schurgers, L J, Thijssen, H H W, De Mey, J G R, Vermeer, C

“…The effects of vitamin K (phylloquinone: K1 and menaquinone-4: MK-4) on vascular calcification and their utilization in the arterial vessel wall were compared…”
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Matrix Gla Protein Accumulates at the Border of Regions of Calcification and Normal Tissue in the Media of the Arterial Vessel Wall by Spronk, Henri M.H., Soute, Berry A.M., Schurgers, Leon J., Cleutjens, Jack P.M., Thijssen, Henk H.W., De Mey, Jo G.R., Vermeer, Cees

“…Vitamin K-dependent matrix Gla protein (MGP) has been suggested to play a role in the inhibition of soft-tissue calcification. Here we report the expression of…”
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Soluble tissue factor is a candidate marker for progression of microvascular disease in patients with Type 2 diabetes by SOMMEIJER, D. W., HANSEN, H. R., VAN OERLE, R., HAMULYAK, K., VAN ZANTEN, A. P., MEESTERS, E., SPRONK, H. M. H., TEN CATE, H.

“…Objective: To determine the relationship between abnormalities in blood coagulation and prevalent or incident cardiovascular complications in Type 2 diabetes…”
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Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice by Frederix, Kim, Chauhan, Anil K, Kisucka, Janka, Zhao, Bing-Qiao, Hoff, Erik I, Spronk, Henri M.H, ten Cate, Hugo, Wagner, Denisa D

“…Abstract Photochemically induced cerebral infarction has been considered a clinically relevant model for ischemic stroke. We evaluated various transgenic mice…”
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An essential role of factor XI-feedback activation for hemostasis in embryonic development by Jamsa, A, Spronk, HMH, Govers-Riemslag, JWP, Knetsch, ML, Gailani, D, Mackman, N, Renne, T

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Total chemical synthesis of human matrix Gla protein by Hackeng, Tilman M., Rosing, Jan, Spronk, Henri M.H., Vermeer, Cees

“…Human matrix Gla protein (MGP) is a vitamin K–dependent extracellular matrix protein that binds Ca2+ ions and that is involved in the prevention of vascular…”
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Novel mutation in the γ-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K–dependent blood coagulation factors by Spronk, Henri M.H., Farah, Roula A., Buchanan, George R., Vermeer, Cees, Soute, Berry A.M.

“…A mutation in the γ-glutamyl carboxylase gene leading to a combined congenital deficiency of all vitamin K-dependent coagulation factors was identified in a…”
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Assay for Human Matrix Gla Protein in Serum: Potential Applications in the Cardiovascular Field by Braam, L A. J. L. M, Dissel, P, Gijsbers, B L. M. G, Spronk, H M. H, Hamulyák, K, Soute, B A. M, Debie, W, Vermeer, C

“…Matrix Gla protein (MGP) is synthesized in a vitamin K–dependent way in smooth muscle cells of the healthy vessel wall, and its mRNA transcription is…”
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Characteristics of recombinant W501S mutated human γ‐glutamyl carboxylase by Soute, B. A. M., Jin, D‐Y., Spronk, H. M. H., Mutucumarana, V. P., Lin, P‐J., Hackeng, T. M., Stafford, D. W., Vermeer, C.

“…A mutation (W501S) in the vitamin K‐dependent γ‐glutamyl carboxylase (VKC) that leads to a congenital bleeding disorder was recently discovered in two…”
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