Search Results - "Spronk, H M"

Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants by Spronk, Henri M H, de Jong, Anne Margreet, Crijns, Harry J, Schotten, Ulrich, Van Gelder, Isabelle C, Ten Cate, Hugo

“…Factor Xa and thrombin are well-known components of the coagulation cascade and have been proven to be viable targets for effective anticoagulation treatment…”
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Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model by Grottke, Oliver, van Ryn, Joanne, Spronk, Henri M H, Rossaint, Rolf

“…New oral anticoagulants are effective alternatives to warfarin. However, no specific reversal agents are available for life-threatening bleeding or emergency…”
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Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease by Kremers, B. M. M., Posma, J. N., Heitmeier, S., Glunz, J., ten Cate, H., Pallares Robles, A., Daemen, J. H. C., ten Cate-Hoek, A. J., Mees, B. M. E., Spronk, H. M. H.

“…Peripheral artery disease (PAD) patients have an increased cardiovascular risk despite pharmacological treatment strategies. Biomarker research improving risk…”
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Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner by Borissoff, Julian I, Otten, Jeroen J T, Heeneman, Sylvia, Leenders, Peter, van Oerle, René, Soehnlein, Oliver, Loubele, Sarah T B G, Hamulyák, Karly, Hackeng, Tilman M, Daemen, Mat J A P, Degen, Jay L, Weiler, Hartmut, Esmon, Charles T, van Ryn, Joanne, Biessen, Erik A L, Spronk, Henri M H, ten Cate, Hugo

“…Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic…”
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Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events by Loeffen, Rinske, van Oerle, René, Leers, Mathie P G, Kragten, Johannes A, Crijns, Harry, Spronk, Henri M H, Ten Cate, Hugo

“…In acute coronary syndrome (ACS) cardiac cell damage is preceded by thrombosis. Therefore, plasma coagulation markers may have additional diagnostic relevance…”
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Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice by Posthuma, Jelle J., Posma, Jens J. N., van Oerle, Rene, Leenders, Peter, van Gorp, Rick H., Jaminon, Armand M. G., Mackman, Nigel, Heitmeier, Stefan, Schurgers, Leon J., ten Cate, Hugo, Spronk, Henri M. H.

“…Atherosclerosis is a progressive inflammatory vascular disorder, complicated by plaque rupture and subsequently atherothrombosis. In vitro studies indicate…”
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Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method by LOEFFEN, R., KLEINEGRIS, M.‐C. F., LOUBELE, S. T. B. G., PLUIJMEN, P. H. M., FENS, D., van OERLE, R., ten CATE, H., SPRONK, H. M. H.

“…Background: Thrombin generation assays are sensitive methods for assessment of the overall clotting potential of plasma, but, despite their common use in…”
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Calibrated automated thrombogram II: removing barriers for thrombin generation measurements by Giesen, P. L. A, Gulpen, A. J. W, van Oerle, R, ten Cate, H, Nagy, M, Spronk, H. M. H

“…Abstract Background Thrombin generation (TG) assessed by Calibrated Automated Thrombogram (CAT-I) reflects the overall capacity of plasma to generate thrombin,…”
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Inadequate response to antiplatelet therapy in patients with peripheral artery disease: a prospective cohort study by Kremers, B M M, Daemen, J H C, Ten Cate, H, Spronk, H M H, Mees, B M E, Ten Cate-Hoek, A J

“…Patients with peripheral artery disease (PAD) are treated with preventive strategies to improve the cardiovascular risk. The incidence of cardiovascular events…”
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Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats by Schurgers, Leon J., Spronk, Henri M.H., Soute, Berry A.M., Schiffers, Paul M., DeMey, Jo G.R., Vermeer, Cees

“…Arterial calcification (AC) is generally regarded as an independent risk factor for cardiovascular morbidity and mortality. Matrix Gla protein (MGP) is a…”
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Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project by Strak, Maciej, Hoek, Gerard, Godri, Krystal J, Gosens, Ilse, Mudway, Ian S, van Oerle, René, Spronk, Henri M H, Cassee, Flemming R, Lebret, Erik, Kelly, Frank J, Harrison, Roy M, Brunekreef, Bert, Steenhof, Maaike, Janssen, Nicole A H

“…Exposure to ambient particulate matter (PM) has been associated with adverse cardiovascular effects in epidemiological studies. Current knowledge of…”
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Thrombin generation capacity of prothrombin complex concentrate in an in vitro dilutional model by Grottke, Oliver, Rossaint, Rolf, Henskens, Yvonne, van Oerle, Rene, Ten Cate, Hugo, Spronk, Henri M H

“…The use of PCC for the treatment of trauma-induced coagulopathy potentially increase the risk of thromboembolism and disseminated intravascular coagulation,…”
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Integrating Mechanisms in Thrombotic Peripheral Arterial Disease by Nagy, Magdolna, van der Meijden, Paola E. J, Glunz, Julia, Schurgers, Leon, Lutgens, Esther, ten Cate, Hugo, Heitmeier, Stefan, Spronk, Henri M. H

“…Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research…”
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Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution by Grottke, Oliver, van Ryn, Joanne, Zentai, Christian, Gan, Guanfa, Honickel, Markus, Rossaint, Rolf, Ten Cate, Hugo, Spronk, Henri M H

“…Idarucizumab is a humanized Fab fragment that specifically reverses dabigatran anticoagulation. In trauma, volume expanders are used for resuscitation to…”
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Thrombin generation in the Glasgow Myocardial Infarction Study by Smid, Machiel, Dielis, Arne W J H, Spronk, Henri M H, Rumley, Ann, van Oerle, Rene, Woodward, Mark, ten Cate, Hugo, Lowe, Gordon

“…Thrombin is a key protease in coagulation also implicated in complex pathology including atherosclerosis. To address the role of thrombin in relation to…”
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Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia by Honickel, Markus, Rieg, Annette, Rossaint, Rolf, Braunschweig, Till, Spronk, Henri M H, ten Cate, Hugo, van Oerle, Rene, Tolba, Rene, Grottke, Oliver

“…Although prothrombin complex concentrate (PCC) is increasingly used for the treatment of trauma-induced coagulopathy, few studies have investigated the impact…”
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Evaluation of the analytical performance of the PC100 platelet counter by Nagy, Magdolna, Fazaeli, Sepanta, van Oerle, René, Ten Cate, Hugo, Schemmann, Marcel, Sherry, John, Kelleher, Gillian, Spronk, Henri M H

“…Platelet count can be altered in various diseases and treatments and measuring it may provide better insight into the expected outcome. So far, quantification…”
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Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia by Spronk, Henri M H, Braunschweig, Till, Rossaint, Rolf, Wüst, Dirk C, van Oerle, Rene, Lauritzen, Brian, Tolba, Rene, Grottke, Oliver

“…Recombinant factor VIIa (rFVIIa) is registered for use in haemophilia with inhibitors and other rare bleeding disorders, but has also been used in various…”
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Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background by van Paridon, Pauline C S, Panova-Noeva, Marina, van Oerle, Rene, Schulz, Andreas, Prochaska, Jürgen H, Arnold, Natalie, Schmidtmann, Irene, Beutel, Manfred, Pfeiffer, Norbert, Münzel, Thomas, Lackner, Karl J, Ten Cate, Hugo, Wild, Philipp S, Spronk, Henri M H

“…The current study aims to identify the relationships between coagulation factors and plasma thrombin generation in a large population-based study by comparing…”
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Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort by Mulder, Mark M G, Schellens, Joep, Sels, Jan-Willem E M, van Rosmalen, Frank, Hulshof, Anne-Marije, de Vries, Femke, Segers, Ruud, Mihl, Casper, van Mook, Walther N K A, Bast, Aalt, Spronk, Henri M H, Henskens, Yvonne M C, van der Horst, Iwan C C, Cate, Hugo Ten, Schurgers, Leon J, Drent, Marjolein, van Bussel, Bas C T

“…Extra-hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), maintains vascular health, with high levels…”
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