Search Results - "Spronck, Lisa"

Therapeutic hFIX Activity Achieved after Single AAV5-hFIX Treatment in Hemophilia B Patients and NHPs with Pre-existing Anti-AAV5 NABs by Majowicz, Anna, Nijmeijer, Bart, Lampen, Margit H., Spronck, Lisa, de Haan, Martin, Petry, Harald, van Deventer, Sander J., Meyer, Christian, Tangelder, Marco, Ferreira, Valerie

“…Currently, individuals with pre-existing neutralizing antibodies (NABs) against adeno-associated virus (AAV) above titer of 5 are excluded from systemic…”
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The Biodistribution and Tolerability of rAAV5-miHTT after Bilateral Intra-striatal Delivery to Non-human Primates (S16.006) by de Haan, Martin, Blits, Bas, Spronck, Lisa, Valles-Sanchez, Astrid, Evers, Melvin, van Deventer, Sander, Kostantinova, Pavlina, Higgins, Joseph

“…Abstract only…”
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Effect of Adeno‐associated Viral Vector Mediated APOE Protective Variants Expression on Tau Pathology in a Tau Mouse Model by Chatterjee, Madhurima, Zuko, Amila, Wattimury, Hendrina, Boggiani, Lorenzo, Paerels, Lieke, Schwarz, Lukas, Hentschel, Lisa, Kusuma, Angga, Bosma, Bas, Villamil, Javier, Spronck, Lisa, Pereira, Ines Lopes, Nogueira, Ana, Peris, Sara Gimeno, de Miguel, Elena, Dobrynin, Greg, Liu, Ying Poi

“…Background Alzheimer’s disease (AD) is characterized by two main pathological hallmarks in the brain, namely, the presence of amyloid plaques and…”
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Safety and Efficacy of an Adeno Associated Virus-Based Vector Carrying the Human Clotting Factor IX Gene (AAV5-hFIX) As Studied in Non-Human Primates by Nijmeijer, Bart, Petry, Harald, Spronck, Lisa, Van Der Kruijssen, Corina, Petersen, Jorgen, Salmon, Florence

“…Restoration of clotting Factor IX (FIX) expression through gene transfer is a promising option for the treatment of Hemophilia B. We have developed an…”
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L4 Sustained and strong HTT silencing by AAV5-miHTT as therapy for huntington’s disease by Evers, Melvin, Miniarikova, Jana, Blits, Bas, Spronck, Lisa, Brouwers, Cynthia, Déglon, Nicole, Motlik, Jan, Bankiewicz, Krystof, Southwell, Amber, Haan, Martin de, Richard, Charles, Petry, Harald, Konstantinova, Pavlina

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the first exon of the HTT gene…”
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664. Improving AAV Gene Therapy Safety Analysis: Multiplex LAM-PCR Provide New Insights Into AAV Vector Integration by Gil-Farina, Irene, Käppel, Christine, Wilkening, Stefan, Lopez-Franco, Esperanza, Astrid Paneda, Maria, Prieto, Jesús, Spronck, Lisa, von Kalle, Christof, Petry, Harald, Gonzalez-Aseguinolaza, Gloria, Schmidt, Manfred

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Safe and efficacious delivery of the human clotting factor IX gene to non human primates using a recombinant AAV vector produced in a fully-scalable GMP-compliant production system by Nijmeijer, Bart A., Petry, Harald, Sonnemans, Marc A., Beattie, Stuart G., Salmon, Lisa Spronck Florence, Preusting, Hans, Van Oorschot, Arie, Twisk, Jaap

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Non-clinical safety evaluation of AAV5-PBGD in mice and cynomolgus macaques by González-Aseguinolaza, Gloria, Pañeda, Astrid, López-Franco, Esperanza, Olagüe, Cristina, Fontanellas, Antonio, Unzu, Carmen, Sampedro, Ana, Cornet, María Eugenia, Municio, María del Mar, Heal, Paul, Petry, Harald, Sonnemans, Marc, Spronck, Lisa, Salmon, Florence

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No longitudinal transmission of AAV5-PBGD vector DNA in mice by Royo, Ana Gloria Gil, González-Aseguinolaza, Gloria, Aizpun, Ismael, Rodríguez, Astrid Pañeda, Cornet, María Eugenia, Municio, María del Mar, Freeman, Tracy, Petry, Harald, Sonnemans, Marc, Spronck, Lisa, Salmon, Florence

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